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First Principles of Medicine
First Principles of Medicine episodes
- #45 - Pulmonary Embolism
Why does a clot in the lungs kill? It isn’t suffocation—it’s mechanical plumbing failure.
In this episode, we strip away all the confusing aspects surrounding Pulmonary Embolism and look at it through a first principles approach. We discuss a very famous triad, V/Q mismatches and how you would approach a patient that has just hopped off a long-haul flight and now has chest pain in the ED 👀 .
Whether you’re on the wards or prepping for exams, this is the fundamental physiological map you need before you ever order that CTPA.
=== Other links ===
1PM Website: https://app.notion.com/p/1pm/45-Pulmonary-Embolism-PE-3b9ef1d0b55f8097a0b6e8d24af06281?v=4d229ecad0cb49b68d92006860e3059d&source=copy_link
Check out our new website 1pm.wiki for the Notion document, free Anki flashcards, and podcast episodes
Instagram: https://www.instagram.com/firstprinciplesofmedicine
Recorded 30 June 2026. Hosts: Titus Leong, Sithum Fernando, Eric Ny, Truman Lo . Produced by Titus Leong.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
@ First Principles of Medicine 2026
43 min - #44B: GORD... in 3 minutes!
***Disclaimer***
We apologise for the audio quality of this episode, we encountered some technical difficulties during recording.
The First Principles of gastroesophageal reflux disease.
Join us as we discuss the pathophysiology, diagnosis and management of GORD, a common condition which you will encounter throughout your medical career.
=== Other Links ===
1PM Website
https://1pm.notion.site/Gastroesophageal-Reflux-Disease-152ef1d0b55f81b29c37f256de847d4a
Check out our new website 1pm wiki for the Notion document, free Anki flashcards, and podcast episodes.
Instagram: https://www.instagram.com/firstprinciplesofmedicine/
Recorded March 2026. Hosts: Norman Luyt, Benjamin Earner, Fahad Saleem
Produced by Norman Luyt.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email
© First Principles of Medicine 2026
4 min - #44A: GORD - Burning, Beltching and Barrett's
***Disclaimer***
We apologise for the audio quality of this episode, we encountered some technical difficulties during recording.
The First Principles of gastroesophageal reflux disease.
Join us as we discuss the pathophysiology, diagnosis and management of GORD, a common condition which you will encounter throughout your medical career.
=== Other Links ===
1PM Website
https://1pm.notion.site/Gastroesophageal-Reflux-Disease-152ef1d0b55f81b29c37f256de847d4a
Check out our new website 1pm wiki for the Notion document, free Anki flashcards, and podcast episodes.
Instagram: https://www.instagram.com/firstprinciplesofmedicine/
Recorded March 2026. Hosts: Norman Luyt, Benjamin Earner, Fahad Saleem
Produced by Norman Luyt.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email
© First Principles of Medicine 2026
41 min - #43 Ectopic Pregnancy
Ectopic pregnancy is an important condition that medical students are bound to come across during their rotations and of course, in exams. In this episode, we go through ectopic pregnancy from the ground up: how it happens, how patients present, how we diagnose it, and what we can actually do about it. We hope this episode helps set you up for your upcoming rotations or act as a nice revision for your ongoing studies.
Join us and find out why, when it comes to pregnancy, location really does matter 👀
#43 - Ectopic Prengnacy
=== Other links ===
1PM Website: https://app.notion.com/p/1pm/43-Ectopic-Pregnancy-3d8ef1d0b55f802ba633de72dd9e422f
Check out our new website 1pm.wiki for the Notion document, free Anki flashcards, and podcast episodes
Instagram: https://www.instagram.com/firstprinciplesofmedicine
Recorded 21 May 2026. Hosts: Sithum Fernando, Eric Ny, Titus Leong. Produced by Sithum Fernando.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
@ First Principles of Medicine 2026
40 min - #42 Deep Vein Thrombosis
Deep Vein Thrombosis (DVT) is a condition we commonly encounter on the wards and in the Emergency Department. But how well do we really understand what is happening beneath the surface?
Join us as we go back to the first principles of medicine to explore DVT—from the underlying pathophysiology and risk factors to recognising the key clinical features and approaching a patient when DVT is suspected. We’ll break down the essentials you need to know to confidently identify DVT in clinical practice and understand why it matters.
Whether you’re revising for exams, on the wards, or preparing for your next ED shift, this episode will help you build a practical, first-principles approach to DVT.
=== Other Links ===
1PM Website
Check out our new website 1pm.wiki for the Notion document, free Anki flashcards, and podcast episodes.
Instagram: https://www.instagram.com/
firstprinciplesofmedicine/
Recorded 18nd June, 2026.
Hosts: Andreana Goh, Jasmyne Le, Angela Goh
Produced by: Andreana Goh
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
© First Principles of Medicine 2026
25 min - #41 - Prostate Cancer & BPH: Reaching Deep into the Prostate
Prostate Cancer and BPH are very common conditions in the elderly males. They are very common conditions in the hospital setting, and medical students are bound to encounter it whilst on their rotations. We hope that this podcast will be able to set you up for success in your coming rotations or act as a nice revision for you ongoing studies.
Join us in reaching deep into the prostate and it's pathology - not just with your mind, but also a finger 🫢
#41 - Prostate Cancer & BPH
=== Other Links ===
1PM Website: https://1pm.notion.site/41-Prostate-Cancer-BPH-3caef1d0b55f8054a2f7c570316a8688?pvs=143
Check out our new website 1pm.wiki for the Notion document, free Anki flashcards, and podcast episodes.
Instagram: https://www.instagram.com/firstprinciplesofmedicine/
Recorded 2nd June, 2026. Hosts: Eric Ny, Sithum Fernando, Titus Leong, Truman Lo . Produced by Eric Ny.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
© First Principles of Medicine 2026
50 min - #40 - Anaphylaxis: Don't Bee Alarmed!
First Principles of Anaphylaxis
Anaphylaxis is one of those conditions you never want to miss, but it can be stressful knowing exactly what to do when every second counts. In this episode, we break it all down from first principles.
We'll cover how to recognise anaphylaxis early, what's actually happening in the body, why adrenaline is the treatment of choice, and the key steps in management. As always, this isn't about memorising guidelines, it's about understanding the why behind your decisions, so you'll feel more confident in OSCEs, on the wards, and in clinical practice.
So grab your matcha, your laptop, or your favourite study snack (just maybe double check it isn't hiding any peanuts 🥜), and let's dive into anaphylaxis. From airway and breathing checks to adrenaline and beyond, because knowing what to do in those first few moments can make all the difference.
=== Other Links ===
Notion notes: https://app.notion.com/p/1pm/40-Anaphylaxis-3b9ef1d0b55f801dbfb1f285f3de9da9?source=copy_link
================
Recording date: 27/5/2026
Guests: Angela Goh, Julia Jolly, and Jasmyne Le
Producer: Jasmyne Le
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
© First Principles of Medicine 2026
29 min - #39B - Abnormal Uterine Bleeding (Part II)
First Principles of Abnormal Uterine Bleeding (AUB)
In this episode, we're going to break it all down from first principles. We'll walk through how to take a focused history without getting lost in the menstrual timeline, what investigations actually matter (and which ones don't), and how management changes depending on what's causing the bleeding.
As always, this isn't about memorising endless lists. It's about understanding the why behind the questions you ask and the tests you order, so the next time you're on ward rounds or in an OSCE, you'll know exactly where to start.
So grab your coffee, your notebook, or your favourite study snack, and let's dive into abnormal uterine bleeding—because periods might be monthly, but OSCEs can ask about them any day of the year!
Disclaimer: This episode was recorded on 8 May 2026. At the time of recording, the condition now known as Polyendocrine Metabolic Ovarian Syndrome (PMOS) was referred to as Polycystic Ovary Syndrome (PCOS). Following the official nomenclature change announced on 12 May 2026, the term PMOS is now preferred. References to "PCOS" in this episode reflect the terminology that was in use at the time of recording.
Check out the online note here: https://1pm.notion.site/39-Abnormal-Uterine-Bleeding-37def1d0b55f803e8439dbd37275bf2c
=== Other Links ===
1PM Website
Check out our new website 1pm.wiki for the Notion document, free Anki flashcards, and podcast episodes.
Instagram
https://www.instagram.com/firstprinciplesofmedicine/
Recorded 8 May 2026.
Hosts: Angela Goh, Julia Jolly, Jasmyne Le
Produced by Angela Goh.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
© First Principles of Medicine 2026
44 min - #39A - Abnormal Uterine Bleeding (Part I)
First Principles of Abnormal Uterine Bleeding (AUB)
Think it's "just PMS"? Think again! In Part I of our AUB series, we dive into what counts as normal menstrual bleeding, when bleeding becomes abnormal, and the common causes behind it. Join us as we unpack the basics of Abnormal Uterine Bleeding and turn a confusing topic into something clear, practical, and surprisingly fascinating.
Disclaimer: This episode was recorded on 1 May 2026. At the time of recording, the condition now known as Polyendocrine Metabolic Ovarian Syndrome (PMOS) was referred to as Polycystic Ovary Syndrome (PCOS). Following the official nomenclature change announced on 12 May 2026, the term PMOS is now preferred. References to "PCOS" in this episode reflect the terminology that was in use at the time of recording.
Check out the online note here: https://1pm.notion.site/39-Abnormal-Uterine-Bleeding-37def1d0b55f803e8439dbd37275bf2c
=== Other Links ===
1PM Website
Check out our new website 1pm.wiki for the Notion document, free Anki flashcards, and podcast episodes.
Instagram
https://www.instagram.com/firstprinciplesofmedicine/
Recorded 1 May 2026.
Hosts: Angela Goh, Andreana Goh, Julia Jolly.
Produced by Angela Goh.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
© First Principles of Medicine 2026
30 min - #38B - Seizures...in 5 minutes!
The First Principles of Seizures (Summary): Join us for the summary version of our seizures episode.
1PM Notion: Seizures
=== Other Links ===
1PM Website
Check out our new website 1pm.wiki for the Notion document, free Anki flashcards, and podcast episodes.
Instagram: https://www.instagram.com/firstprinciplesofmedicine/
Recorded 27th of July, 2025. Hosts: Benjamin Earner, Saud Rana, Jasper Jackson. Produced by Benjamin Earner.
If you have any ideas or feedback, comment on this Notion document, or shoot us an email at [email protected]
© First Principles of Medicine 2025
5 min
About First Principles of Medicine
From the publisher's feed
🌐 1PM.WIKI 🌐
🔍 🎲 Welcome to 1PM, in this series we will be breaking down complex medical topics into their First Principles.
😟 When the stress is on, and you’ve just been asked a tough question you don’t know the answer to, we feel you’ll be able to fall back on these principles to formulate a decent answer and reason your way out of trouble.