🧬 New Insights into Gut–Heart Axis 🫀💡

Groundbreaking research published in Nature shows that Imidazole propionate (ImP)—a metabolite produced by gut bacteria—drives atherosclerosis by hijacking immune pathways in myeloid cells via the I1R–mTORC1 axis 🔥🧫.

📈 Elevated ImP levels predicted subclinical atherosclerosis independently of cholesterol in two large cohorts (PESA & IGT).

💊 Blocking this pathway with AGN192403 prevented plaque buildup—offering a novel, cholesterol-independent therapeutic target.

📚 Time to rethink cardiovascular prevention beyond lipids?

#Cardiology #GutMicrobiome #Atherosclerosis #PrecisionMedicine #Inflammation #NatureMedicine