Sarah Yingling, a nurse who led a quality improvement (QI) project in her unit, and Dr. Elizabeth Schierholz, a neonatal nurse practitioner, nurse scientist, and Sarah’s mentor, share how bedside nurses and APRNs can overcome the intimidation often associated with research, evidence-based practice (EBP), and QI in the NICU. Sarah recounts her journey from a simple conversation about improving care for small babies to leading a large QI project focused on neuroprotective and family-centered care. Together, they provide practical advice on engaging with research, EBP, and QI, break down nursing barriers, and emphasize the importance of mentorship and small, actionable steps. Whether you are a new nurse or a seasoned professional, this episode demonstrates that meaningful change in patient care is within reach for all.