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In this special Tech Tuesday episode of The Incubator Podcast, Ben and Daphna sit down with Anthony Wu, CEO of Capnia, Inc., to explore how end-tidal carbon monoxide (ETCO) monitoring is impacting neonatal jaundice management. Anthony explains how this technology, based on decades of research, provides a real-time, non-invasive biomarker for hemolysis and thus indirectly, bilirubin production, allowing clinicians to better assess and predict neonatal jaundice severity. Unlike traditional serum bilirubin tests, which only measure bilirubin levels at a given time, ETCO screening gives insight into hemolysis rates, helping identify newborns at risk for severe jaundice before complications arise.

Anthony shares his personal motivation behind this innovation, discussing how his own children experienced neonatal jaundice and how many families suffer the emotional and financial burden of this pathology. He envisions a future where universal ETCO screening becomes standard practice, allowing for earlier interventions and reducing the risk of preventable neurological damage.

Tune in for an eye-opening discussion on how this innovation could change the way we approach neonatal jaundice forever!

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of The Incubator’s Journal Club, hosts Ben and Daphna open with exciting announcements, including details on the upcoming Delphi Neonatal Innovation Conference and new video content for their “Beyond the Beeps” series on YouTube. They also share updates on the Board Review Podcast, geared toward both board preparation and ongoing learning in neonatology.

The team’s first paper discussion highlights the ECLA trial from The Lancet, which examines higher versus lower CPAP levels for extubating extremely preterm infants. Ben and Daphna explore how higher CPAP may decrease extubation failure and the implications for clinical practice. Next, they review a large population-based study on intraventricular hemorrhage (IVH), underscoring the persistently high rates of IVH in very preterm infants and emphasizing its impact on neurodevelopmental outcomes.

They then welcome guest speaker Dr. Tim Barr from the University of Utah, who introduces the concept of end-tidal carbon monoxide monitoring as a noninvasive tool for detecting hemolysis and guiding bilirubin management. Dr. Barr explains how this method may help clinicians identify and treat high-risk neonates earlier. The discussion closes with a look at recent data on early hydrocortisone use in neonatal shock and a paper examining discrepancies between parental and medical classifications of neurodevelopmental impairment. Through in-depth research reviews and expert commentary, this episode showcases The Incubator’s commitment to advancing neonatal care.

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Parental and Medical Classification of Neurodevelopment in Children Born Preterm.

Richter LL, Janvier A, Pearce R, Bourque CJ, Church PT, Luu TM, Synnes A.Pediatrics. 2025 Feb 1;155(2):e2024066148. doi: 10.1542/peds.2024-066148.PMID: 39786567

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Early hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial.

Dudeja S, Saini SS, Sundaram V, Dutta S, Sachdeva N, Kumar P.J Perinatol. 2025 Feb 13. doi: 10.1038/s41372-025-02222-3. Online ahead of print.PMID: 39948354

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Improvement Initiative: End-Tidal Carbon Monoxide Measurement in Newborns Receiving Phototherapy.

Bahr TM, Shakib JH, Stipelman CH, Kawamoto K, Lauer S, Christensen RD.J Pediatr. 2021 Nov;238:168-173.e2. doi: 10.1016/j.jpeds.2021.07.008. Epub 2021 Jul 11.PMID: 34260896

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Intraventricular Hemorrhage and Survival, Multimorbidity, and Neurodevelopment.

Rees P, Gale C, Battersby C, Williams C, Carter B, Sutcliffe A.JAMA Netw Open. 2025 Jan 2;8(1):e2452883. doi: 10.1001/jamanetworkopen.2024.52883.PMID: 39761048 

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Higher versus lower nasal continuous positive airway pressure for extubation of extremely preterm infants in Australia (ÉCLAT): a multicentre, randomised, superiority trial.

Kidman AM, Manley BJ, Boland RA, Malhotra A, Donath SM, Beker F, Davis PG, Bhatia R.Lancet Child Adolesc Health. 2023 Dec;7(12):844-851. doi: 10.1016/S2352-4642(23)00235-3. Epub 2023 Oct 27.PMID: 38240784 Clinical Trial.

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Being a NICU parent comes with many challenges, but communicating with your baby’s healthcare team and loved ones doesn’t have to be one of them. In this video, NICU parent Valerie shares her personal journey and offers valuable tips for effective communication with doctors and medical providers. Learn how the right tools and conversations can improve your NICU experience, while also highlighting the importance of self-care, hope, and trust during this difficult time. Whether you’re navigating the NICU or supporting a loved one, this episode provides crucial insights for every NICU family.

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In part two of our conversation with Dr. Phyllis Dennery, Ben and Daphna dive into the themes of leadership and gratitude. Dr. Dennery shares her journey from growing up in a hospital environment to becoming a leader in neonatology, reflecting on how mentorship, self-awareness, and courage shaped her path. She discusses the importance of saying “no” when necessary, embracing leadership roles, and advocating for diversity and equity in medicine.

Dr. Dennery offers insights into the power of observation, collaboration, and fostering a culture of kindness and gratitude within healthcare teams. She also addresses the unique challenges faced by women in medicine, the impact of representation on patient outcomes, and how personal and professional growth evolve over time.

Beyond her medical career, she speaks about her passion for advocacy, research, and even creative writing, hinting at exciting projects ahead. This inspiring discussion is filled with wisdom for early-career neonatologists and leaders alike, encouraging them to find joy in their work, uplift others, and make a lasting impact in the field.

Tune in for an insightful and heartfelt conversation with one of neonatology’s most influential voices!

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode, I had the pleasure of speaking with Dr Shayla Percy, who is now a third year Neonatology fellow UPMC Children’s Hospital of Pittsburgh. Shayla described her QI project and the steps she took with her team to improve detection and management of metabolic disease of prematurity. She talked about the team work and the support from her mentors that set her up for a successful project. We also talked about some of the challenges that she experienced and how she tackled it. Shayla completed QI courses during the fellowship and also won the AAP young investigator award for her project. Shayla shared her experience presenting her work at AAP and provided insights to future incoming fellows who might be interested in a similar research pathway. 

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!