The Incubator

Send us a text

In this engaging conversation, Dr. Emin Maltepe shares his journey as a neonatologist and physician scientist, discussing the serendipitous events that shaped his research interests, particularly in hypoxia and drug development for neonatology. He reflects on the importance of mentorship, the challenges of drug development in pediatrics, and the MD-PhD pathway, providing insights into the complexities of balancing clinical practice with research. In this conversation, Emin Maltepe discusses his journey through the MD-PhD program and how it shaped his career in pediatric drug development. He highlights the significant challenges faced in developing therapeutics for pediatric populations, particularly preterm infants, and the lack of attention and funding in this area. Emin shares insights into his innovative approaches to drug and device development, including collaborations with global organizations and the importance of using appropriate animal models. He emphasizes the need for policy advocacy and business knowledge in the field of pediatric therapeutics, while also reflecting on the personal challenges and rewards of balancing family life with a demanding career.

Resources mentioned in episode:

https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.048264

https://journals.lww.com/shockjournal/fulltext/2024/07000/omx__a_novel_oxygen_delivery_biotherapeutic.14.aspx

https://www.nature.com/articles/s41598-023-36653-9

https://www.nature.com/articles/s41587-021-00866-y

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005924

Episode Webpage Link:

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

In this inaugural episode of our brand-new series, NeoNews, hosts Ben Courchia, Daphna Yasova Barbeau, and new team member Dr. Eli Cahan dive into articles from major news outlets like Rolling Stone, The Wall Street Journal, and The New York Times to unpack their relevance to neonatology, newborn care, and perinatology.

Dr. Cahan, a pediatrician and aspiring neonatologist with a background in journalism, leads discussions on critical topics, including prenatal cannabis use and its impact on families, disparities in treatment for 22-week preemies, the neuroscience of "mom brain," rising rates of sudden infant death syndrome (SIDS) post-COVID, and the concerning state of maternity care deserts in the U.S.

The episode concludes with quick updates on viral health concerns and a significant FDA meeting on probiotics for NEC prevention. Join us as we bring the latest news to the neonatal community in this exciting new format!

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

This episode of the Global Neonatal Podcast features reflections from the Tiny Feet Big Steps Conference, highlighting the growth and impact of neonatal care initiatives in Africa. Dr. Steven Swanson and Dr. Margaret Nakaketo share insights on the importance of networking, quality improvement, and the future of neonatology in the region. The conversation emphasizes collaboration, the need for real-time translation in training, and the significance of engaging with healthcare systems and government for better newborn care.

Resources mentioned in episode:

Link to playlist from Tiny Feet Big Steps conference https://youtube.com/playlist?list=PL-94lDL-ozLatIqf_yQVHjubePerN7NGg&si=fgFOBLpWVP2w5Yy4

Institute of Child Health Africa (ICHA) https://www.tanzanianchildren.com

Tiny Feet Big Steps Conference https://tinyfeetbigsteps.com

Episode Webpage Link: https://www.the-incubator.org/post/255-reflections-from-the-tiny-feet-big-steps-conference-in-arusha-tanzania-ft-dr-stephen-swa

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

In this latest episode of The Incubator Podcast Journal Club, Ben and Daphna explore studies that may shift clinical practices in neonatal care. They begin with a study from India examining oral calcium phosphate as an adjunct to phototherapy in treating neonatal jaundice. This double-blind, randomized, placebo-controlled trial investigates how calcium phosphate may help reduce bilirubin levels by binding to unconjugated bilirubin in the gut, potentially minimizing the need for prolonged phototherapy. The findings suggest that calcium phosphate could lower phototherapy duration and decrease cases of rebound hyperbilirubinemia, offering a possible new approach for jaundiced newborns.

The episode also covers an intriguing study on alternative treatments for persistent pulmonary hypertension of the newborn (PPHN). By comparing oral sildenafil to bosentan, this research sheds light on the potential of sildenafil to reduce PASP more efficiently, especially in resource-limited settings. The team discusses these insights and examines how they may influence care for PPHN cases worldwide.

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

The who, when, and why of pacifier use.

Mitev K, Frewin KL, Augustinova M, Niedenthal PM, Rychlowska M, Vanderwert RE.Pediatr Res. 2024 Oct 15. doi: 10.1038/s41390-024-03540-6. Online ahead of print.PMID: 39406952

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

National Trends in Infant Mortality in the US After Dobbs.

Singh P, Gallo MF.JAMA Pediatr. 2024 Oct 21. doi: 10.1001/jamapediatrics.2024.4276. Online ahead of print.PMID: 39432283

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

Cooling and physiology during parent cuddling infants with neonatal encephalopathy in usual care: CoolCuddle-2 study.

Chakkarapani E, Ingram J, Stocks S, Beasant L, Odd D; CoolCuddle‐2 study research team.Acta Paediatr. 2024 Oct 25. doi: 10.1111/apa.17466. Online ahead of print.PMID: 39451123

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

Inpatient Skin-to-skin Care Predicts 12-Month Neurodevelopmental Outcomes in Very Preterm Infants.

Lazarus MF, Marchman VA, Brignoni-Pérez E, Dubner S, Feldman HM, Scala M, Travis KE.J Pediatr. 2024 Nov;274:114190. doi: 10.1016/j.jpeds.2024.114190. Epub 2024 Jul 14.PMID: 39004169

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions.

Ziegler A, Koval-Burt C, Kay DM, Suchy SF, Begtrup A, Langley KG, Hernan R, Amendola LM, Boyd BM, Bradley J, Brandt T, Cohen LL, Coffey AJ, Devaney JM, Dygulska B, Friedman B, Fuleihan RL, Gyimah A, Hahn S, Hofherr S, Hruska KS, Hu Z, Jeanne M, Jin G, Johnson DA, Kavus H, Leibel RL, Lobritto SJ, McGee S, Milner JD, McWalter K, Monaghan KG, Orange JS, Pimentel Soler N, Quevedo Y, Ratner S, Retterer K, Shah A, Shapiro N, Sicko RJ, Silver ES, Strom S, Torene RI, Williams O, Ustach VD, Wynn J, Taft RJ, Kruszka P, Caggana M, Chung WK.JAMA. 2024 Oct 24:e2419662. doi: 10.1001/jama.2024.19662. Online ahead of print.PMID: 39446378

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us a text

Genetic disorders and their association with morbidity and mortality in early preterm small for gestational age infants.

Bomback M, Everett S, Lyford A, Sahni R, Kim F, Baptiste C, Motelow JE, Tolia V, Clark R, Dugoff L, Hays T.Am J Obstet Gynecol. 2024 Sep 23:S0002-9378(24)01013-5. doi: 10.1016/j.ajog.2024.09.101. Online ahead of print.PMID: 39322018

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!