From science to startup: real talk on biotech founding paths. For many early-stage biotech founders, that’s where the real challenge begins—and that’s where Persephoni Bio Partners comes in. In this episode of the Nucleate Podcast, Hillary Schultz and Dr. William Heath share how their unique journeys from clinical medicine and pharmaceutical R&D to early-stage investing led them to co-found Persephoni Bio, a venture studio focused on transforming breakthrough science into scalable biotech companies. Hillary and William reveal the most overlooked reasons biotech startups struggle, highlighting that success often hinges more on the team than the technology. They offer candid insights into IP strategy, founder dynamics, and patient-centered development, while also emphasizing the importance of resilience, adaptability, and a growth mindset.

For anyone navigating the next step after Nucleate, this episode offers practical guidance and inspiration for building biotech that lasts! 

Time Stamps

• Personal Background and Motivation: 
  • 0:03:40 - Hillary discusses her early passion for heathcare and impact
  • 0:07:07 - William explains his journey into science, starting from childhood
• Nucleate Experience: 
  • 0:14:12 - Hillary's advice on making the most of Nucleate
  • 0:16:45 - William's perspective on Nucleate's value
• Persephoni Bio Partners:
  • 0:26:09 - Hillary explains the founding of Persephoni
  • 0:28:56 - William discusses the mission of supporting early-stage biotech
• IP and Technical Challenges:
  • 0:47:48 - Discussion on IP strategies for startups
  • 0:57:11 - Technical challenges in biotech development
  • 0:58:39 - Importance of understanding patient needs
• Entrepreneurship Advice:
  • 1:02:11 - Advice for Nucleate Activator program graduates
  • 1:05:00 - Discussing entrepreneurial mindset and resilience
  • 1:07:24 - Embracing failure as a learning opportunity
• Personal Balance: 
  • 1:10:47 - Hillary and William discuss work-life balance
  • 1:13:47 - Importance of team dynamics in success