What if a mouse could help shape the future of cancer treatment? In this episode of Sounds of Science, host Mary Parker speaks with Julia Schüler, DVM, PhD, Research Director and Therapeutic Area Lead for Oncology at Charles River. Julia shares how patient-derived xenograft (PDX) models—often described as “avatars” of human tumors—are transforming preclinical oncology research. From preserving tumor heterogeneity to improving translational relevance, PDX models are accelerating the discovery of more effective, personalized therapies. Tune in as we explore how these advanced models are driving innovation across the drug development pipeline—from target discovery to clinical trial design.

Show Notes

• PDX Tumor Organoids : A New Tool in Drug Discovery Testing Realm 
• Organoids: Some Assembly Required 
• Patient-Derived Xenografts- PDX Models 
• 3D Tumor Models 
• In Vitro PDX Assays