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Genes, CAD Risk, Destiny 🧬
🧬 Why Coronary Artery Disease Runs in Families
Coronary artery disease is not just lifestyle—it is deeply genetic. Rare monogenic disorders like familial hypercholesterolemia and hundreds of common variants together shape lifelong risk, with polygenic risk scores identifying individuals whose inherited risk rivals traditional factors 🫀.
The good news: genetic risk is modifiable. Early LDL lowering, healthy lifestyles, and precision prevention deliver the greatest benefit in those at highest inherited risk 🔬.
A timely synthesis from The New England Journal of Medicine (2026) that reframes CAD—from destiny to opportunity.
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By Dr RR Baliga, MD, MBA
5
66 ratings
🧬 Why Coronary Artery Disease Runs in Families
Coronary artery disease is not just lifestyle—it is deeply genetic. Rare monogenic disorders like familial hypercholesterolemia and hundreds of common variants together shape lifelong risk, with polygenic risk scores identifying individuals whose inherited risk rivals traditional factors 🫀.
The good news: genetic risk is modifiable. Early LDL lowering, healthy lifestyles, and precision prevention deliver the greatest benefit in those at highest inherited risk 🔬.
A timely synthesis from The New England Journal of Medicine (2026) that reframes CAD—from destiny to opportunity.
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