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Giants vs Vikings injury news is piling up fast as Week 16 approaches, with major offensive line and defensive injuries on both sides that could significantly impact Sunday’s matchup. We break down the full Vikings injury report, the latest Giants practice updates, and what it all means for the Giants heading into a critical Week 16 game.

Who’s really in danger of being shut down for the season? Which injuries matter most at the line of scrimmage? And how much does this shift the Giants vs Vikings outlook?

After the injury breakdown, we roll through our full Week 16 NFL picks, including Rams vs Seahawks, Eagles vs Commanders, Packers vs Bears, Chargers vs Cowboys, Vikings vs Giants, Bengals vs Dolphins, and the rest of the Sunday slate. We focus on matchups, injury impact, recent trends, and game flow — not just picking logos.

Drop your picks in the comments and let us know where you disagree.

Subscribe for daily Giants coverage, live shows, and real discussion leading into Week 16.

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