Host: Mark Nolan Hill, MD

Guest: Mark Denison, MD

Severe acute respiratory syndrome (SARS) made significant headlines in 2003, testing the mettle of our global public health infrastructure. Since then, we have seen robust evidence to suggest that bats were the original animal host for the virus, with the latest data coming from a synthetic SARS-like bat coronavirus. These most recent efforts were led by the research team of Dr. Mark Denison, professor of pediatrics and associate professor of microbiology and immunology at Vanderbilt University School of Medicine. Dr. Denison details this work with host Dr. Mark Nolan Hill. From a global perspective, how does our ability to synthesize complex viruses like this one enhance our capacity to deal with threatening pathogens?

Host: Mark DeLegge, MD

Guest: David Peura, MD

Constipation is a common symptom that presents more often in women and as patients get older. What are the primary and secondary causes of chronic constipation? What are some of the differentiating factors between chronic constipation and IBS-C? Dr. David Peura, professor of medicine at the University of Virginia School of Medicine, joins host Dr. Mark DeLegge to discuss algorithms for diagnosing chronic constipation. When are lifestyle changes not enough for treating chronic constipation, and what are the most effective alternatives?

Host: Mark DeLegge, MD

Guest: Rowen Zetterman, MD

Acetaminophen, vitamin supplements and antibiotics are just a few of the medications that can cause liver injury. What are the signs of drug-induced liver injury? Are the effects immediate, or do the effects become noticeable after an extended period of time? Dr. Rowen Zetterman, professor of internal medicine at the University of Nebraska Medical Center, provides an overview of factors that might lead to drug-induced liver injury. Dr. Mark DeLegge hosts.

Host: Mark DeLegge, MD

Guest: Mark Donowitz, MD

Are there fewer physician-scientists today than there were a few decades ago? What does the future landscape look like for medical research? Dr. Mark Donowitz, LeBoff Professor of Medicine and director of the Center for Epithelial Disorders at the Johns Hopkins University School of Medicine, as well as immediate past-president of the American Gastroenterological Association, discusses some of the barriers and challenges physician-scientists face, and how we can ensure a sound future for research. Dr. Mark DeLegge hosts.

Host: Mark DeLegge, MD

Guest: Donald Castell, MD

How common is Barrett's esophagus in patients with chronic gastroesophageal reflux disease (GERD) or asymptomatic reflux? What risk factors might predict a diagnosis of Barrett's esophagus? Dr. Donald Castell, professor of medicine and director of the esophageal disorder program at the Medical University of South Carolina, joins host Dr. Mark DeLegge to discuss this potentially pre-cancerous condition.

Host: Mary Leuchars, MD

Guest: Tim Davis, MD, PhD

Malaria control is challenging in regions of the world where there is intense year-round transmission of multiple species. What do the results from a recent clinical trial in one such area — Papua New Guinea — tell us about treating this disease? Principle investigator Dr. Tim Davis, a professor of medicine at the University of Western Australia, shares the results of his NEJM-published study on combination antimalarial therapies in children from Papua New Guinea. Hosted by Dr. Mary Leuchars.

Host: Mary Leuchars, MD

Guest: William Collins, PhD

Each year, over one million people die of malaria and its complications. Can malaria ever be eliminated, and is a malaria vaccine the answer? Speaking with host Dr. Mary Leuchars on this important subject is Dr. William Collins, senior biomedical research scientist at the Centers for Disease Control and Prevention. Dr. Collins has been a leading expert on malaria and antimalarial vaccine developments for the past 50 years. In this interview he describes a hopeful beginning for malaria vaccines, predicated on research from the past 20 years, toward eliminating the disease burden globally.

Host: Mary Leuchars, MD

Guest: William Collins, PhD

Malaria is the most deadly vector-borne disease in the world, and physicians need to be current on its biology, global disease burden, and advancing treatments. Dr. William Collins, senior biomedical research scientist at the Centers for Disease Control and Prevention, has been a leading expert on malaria and antimalarial vaccine developments for the past 50 years. He joins host Dr. Mary Leuchars to update listeners on the cycle of disease transmission, scope of burden across the world, and the path toward prevention and vaccine development.

Host: Maurice Pickard, MD

Guest: Milton Ochieng, MD

Guest: Frederick Ochieng

Growing up in Lwala, Kenya, a small rural community in western Africa, 45 minutes from the nearest paved road and two hours from a hospital, brothers Milton and Fred Ochieng' watched members in their community die simply because they could not get to a doctor quickly enough. As children, the brothers began to dream of building a healthcare facility in Lwala. In this segment, Dr. Milton Ochieng', a resident at Barnes-Jewish Hospital in St. Louis, and his younger brother, Fred Ochieng', a third-year medical student at Vanderbilt Medical School in Nashville, Tennessee, tell host Dr. Maurice Pickard the story of how, with the aid of grassroot efforts in the US, they empowered the local community in the village where they grew up to build a clinic of its own.

Host: Maurice Pickard, MD

Guest: Milton Ochieng, MD

Guest: Frederick Ochieng

Growing up in the isolated village of Lwala, Kenya, without electricity or running water, 45 minutes from the nearest paved road and two hours from the nearest hospital, the Ochieng' brothers wanted to do something to improve lives in their community. Host Dr. Maurice Pickard welcomes Dr. Milton Ochieng', a resident at Barnes-Jewish Hospital in St. Louis, and his younger brother, Fred Ochieng', a third-year medical student at Vanderbilt Medical School in Nashville, Tennessee. They tell the story of how their village pooled its resources to send them to the United States for an education, and the health clinic they returned to Lwala to build. Listen in to learn about the first 18 months at the Ochieng' Memorial Lwala Community Health Center, which has served 25,000 patients at the time of this story.