Good Medicine Podcast

Living longer sounds great. But what if those additional years are spent dealing with chronic disease, limited mobility, and declining health?

In this episode of the Good Medicine Podcast, Dr. David Bearss and his brother Jeremiah discuss why the conversation around longevity is shifting away from simply extending lifespan and toward something potentially much more valuable: extending healthspan.

Healthspan is the portion of your life spent in good health. Instead of asking how we can add more years at the end of life, Dave and Jeremiah explore whether medicine can delay the onset of chronic disease and compress the period of poor health that many people experience as they get older.

What if the goal isn't living to 100?

What if it's reaching your 80s or 90s while remaining healthy, independent, and able to enjoy your life for as long as possible?

Dave and Jeremiah discuss why slowing the biological processes associated with aging could change not only how long we live, but what those later years actually look like.

Topics covered include:

• Lifespan vs. healthspan• Why living longer isn't necessarily living better• Chronic disease and aging• Compressing the years spent in poor health• Slowing the aging process• Rethinking what successful aging actually means

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Could having a strong sense of purpose actually influence how long you live?

In this episode of the Good Medicine Podcast, Dr. David Bearss and his brother Jeremiah discuss research connecting a strong sense of purpose with longevity and better health.

They explore why having something meaningful to work toward may affect more than just how we feel. Purpose could influence our psychology, our daily decisions, and the healthy behaviors that add up over a lifetime.

Dr. Bearss also discusses growing concerns around the number of people who report feeling that their lives lack meaning and why our psychological well-being may have a greater impact on physical health than we realize.

The conversation raises a bigger question about longevity: Is living a long, healthy life just about what you do, or does having a reason to do it matter too?

Topics covered include:

• The connection between purpose and longevity

• Why meaning matters for our health

• Psychology and physical well-being

• Purpose and healthy behaviors

• Exercise, nutrition, and sleep

• What it means to live a meaningful life

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Forgetting names, losing your train of thought, or feeling like your memory isn't as sharp as it used to be is often written off as a normal part of getting older. But how do you know when memory loss is normal and when it could signal something more serious?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss explore what happens to memory as we age and how age-related cognitive decline differs from diseases like Alzheimer's.

They discuss why it can be difficult to distinguish normal changes in memory from the early stages of disease, and why researchers are increasingly challenging the idea that cognitive decline is simply an unavoidable consequence of getting older.

The conversation also explores an emerging connection between bone marrow function, the immune system, and brain health. Dave discusses why improving bone marrow function could potentially open new approaches to preserving or restoring brain function as we age.

Topics covered include:

• Why memory changes as we get older
• Normal memory loss vs. Alzheimer's disease
• Whether age-related cognitive decline can be influenced
• The connection between bone marrow and brain health
• The future of treating cognitive decline

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Energy drinks have a bad reputation. But are they actually bad for you?

In this episode of the Good Medicine Podcast, Dr. Jeremiah Bearss sits down with internal medicine physician Dr. Brian Parker to separate what we know about energy drinks and caffeine from what gets repeated online.

They discuss how the shift toward sugar-free energy drinks has changed the conversation, what caffeine actually does to the body, and why the popular advice to wait 60 to 90 minutes after waking before consuming caffeine isn't as scientifically established as social media might make it seem.

Dr. Parker also explains why caffeine can be a useful tool when used intelligently, while still being a poor substitute for addressing the reasons you're tired in the first place.

The answer to whether energy drinks are "good" or "bad" turns out to be a lot more nuanced than the label on the can.

Topics covered include:

• Are energy drinks actually unhealthy?

• Sugar-free vs. traditional energy drinks

• Caffeine and its effects on the body

• Should you wait 60 to 90 minutes for your morning caffeine?• When caffeine can actually be useful

• Using caffeine without relying on it for energy

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Moderna and Merck just announced major Phase 3 results for their personalized mRNA cancer vaccine.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss break down the newly announced results from the Phase 3 INTerpath-001 trial in patients with high-risk melanoma.

The trial met both of its primary endpoints, showing improvement in recurrence-free survival and distant metastasis-free survival when the individualized therapy was combined with Keytruda.

Dave and JJ explain why seeing an effect across both measures is significant, what makes a therapeutic cancer vaccine different from the vaccines most people are familiar with, and why these results could represent an important step toward personalized cancer vaccines becoming part of cancer treatment.

They also discuss what still needs to happen, who may ultimately benefit from this type of therapy, and why Dave believes there is a real clinical signal in the data.

Topics covered include:

• Moderna and Merck's new Phase 3 cancer vaccine results

• How personalized mRNA cancer vaccines work

• Therapeutic vaccines vs. traditional vaccines

• Recurrence and distant metastasis in melanoma

• What these results could mean for future cancer treatment

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The supplement industry is worth billions of dollars, but are supplements really the key to better health?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the science behind supplements, vitamins, protein, creatine, BPC-157, and the importance of building a strong health foundation before looking for shortcuts.

They explain why nutrition, exercise, sleep, and stress management have a much greater impact on long-term health than any supplement, why vitamins are essential only when correcting a deficiency, and what the current evidence actually says about popular compounds like BPC-157.

The conversation separates evidence from marketing and focuses on what is most likely to improve your health.

Topics covered include:

• Why supplements can't replace healthy habits

• When vitamins are actually beneficial

• What the evidence says about BPC-157

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For decades, diseases have been classified by where they occur in the body. But that may not be the best way to treat them.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss biomarkers and why they are changing the future of medicine.

They explore how two patients with the same diagnosis may have completely different underlying biology, why treatments should increasingly be matched to those biological differences, and how biomarkers are helping move medicine toward truly personalized care.

The conversation also examines why the best treatment is often preventing disease before symptoms ever appear and how biomarkers may help identify risk years earlier.

Topics covered include:

• Why biomarkers are changing cancer treatment

• The future of personalized medicine

• Preventing disease before it begins

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Drug discovery has changed dramatically over the past few decades.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss sit down with longtime colleague Dr. Hari Vankayalapati to discuss how the field has evolved and where it's headed next.

Together, they reflect on lessons learned throughout their careers, including a philosophy that has shaped their approach to developing new medicines: start with the end goal and work backward from the clinical trial needed for approval.

They also explore how artificial intelligence is transforming research by accelerating discovery, reducing cost, and helping scientists analyze data more efficiently. But while AI is becoming an increasingly valuable tool, they explain why human judgment remains essential to making the right scientific decisions.

Topics covered include:

• How AI is changing modern drug discovery

• Why successful drug development starts with the end in mind

• Why scientists remain essential in the age of AI

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Every year, promising therapies fail in clinical trials. But failure doesn't always mean the drug didn't work.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss explain how clinical trials work, why so many therapies never make it to patients, and the complexity behind bringing a new medicine to market.

They discuss the different reasons a clinical trial may fail, why meeting a clinical endpoint doesn't always lead to FDA approval, and how commercial viability plays a major role in determining whether a therapy ultimately reaches patients.

The conversation also explores how artificial intelligence may transform drug development by identifying biological patterns and therapeutic targets that humans would struggle to find on their own.

Topics covered include:

• Why drugs fail clinical trials• The challenges of FDA approval and commercialization• How AI could improve the future of drug development

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The anti-aging industry promises longer life, but is that really the goal?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss separate science from hype as they discuss what actually matters when it comes to aging.

They explore why many age-related diseases are closely tied to the biology that helps us reproduce, why curing a single disease like cancer would add surprisingly little to the average human lifespan, and why the real goal should be extending healthspan rather than simply living longer.

The conversation also looks at why so much healthcare spending occurs in the final years of life and what individuals can do today to stay healthier for longer.

Topics covered include:

• Why aging and cancer are biologically connected• The difference between lifespan and healthspan• Why staying healthy matters more than simply living longer

🎧 Listen on Spotify and Apple Podcasts📺 Subscribe for more conversations on science, medicine, and innovation.

Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/litt

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