For decades, diseases have been classified by where they occur in the body. But that may not be the best way to treat them.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss biomarkers and why they are changing the future of medicine.

They explore how two patients with the same diagnosis may have completely different underlying biology, why treatments should increasingly be matched to those biological differences, and how biomarkers are helping move medicine toward truly personalized care.

The conversation also examines why the best treatment is often preventing disease before symptoms ever appear and how biomarkers may help identify risk years earlier.

Topics covered include:

• Why biomarkers are changing cancer treatment

• The future of personalized medicine

• Preventing disease before it begins

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Drug discovery has changed dramatically over the past few decades.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss sit down with longtime colleague Dr. Hari Vankayalapati to discuss how the field has evolved and where it's headed next.

Together, they reflect on lessons learned throughout their careers, including a philosophy that has shaped their approach to developing new medicines: start with the end goal and work backward from the clinical trial needed for approval.

They also explore how artificial intelligence is transforming research by accelerating discovery, reducing cost, and helping scientists analyze data more efficiently. But while AI is becoming an increasingly valuable tool, they explain why human judgment remains essential to making the right scientific decisions.

Topics covered include:

• How AI is changing modern drug discovery

• Why successful drug development starts with the end in mind

• Why scientists remain essential in the age of AI

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Every year, promising therapies fail in clinical trials. But failure doesn't always mean the drug didn't work.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss explain how clinical trials work, why so many therapies never make it to patients, and the complexity behind bringing a new medicine to market.

They discuss the different reasons a clinical trial may fail, why meeting a clinical endpoint doesn't always lead to FDA approval, and how commercial viability plays a major role in determining whether a therapy ultimately reaches patients.

The conversation also explores how artificial intelligence may transform drug development by identifying biological patterns and therapeutic targets that humans would struggle to find on their own.

Topics covered include:

• Why drugs fail clinical trials• The challenges of FDA approval and commercialization• How AI could improve the future of drug development

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The anti-aging industry promises longer life, but is that really the goal?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss separate science from hype as they discuss what actually matters when it comes to aging.

They explore why many age-related diseases are closely tied to the biology that helps us reproduce, why curing a single disease like cancer would add surprisingly little to the average human lifespan, and why the real goal should be extending healthspan rather than simply living longer.

The conversation also looks at why so much healthcare spending occurs in the final years of life and what individuals can do today to stay healthier for longer.

Topics covered include:

• Why aging and cancer are biologically connected• The difference between lifespan and healthspan• Why staying healthy matters more than simply living longer

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Gene editing has long felt like science fiction. Today, it is becoming a clinical reality.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss explore the rapid progress of gene editing and the opportunities and ethical questions that come with it.

They discuss new evidence suggesting that a single treatment may be able to permanently edit genes in the liver to lower cholesterol, the ethical challenges surrounding gene editing in embryos, and why preventing disease before it begins may fundamentally change the future of medicine.

The conversation examines not only what gene editing can do, but also how society should think about using it responsibly.

Topics covered include:

• How gene editing is moving from theory to reality• The ethical questions surrounding embryo gene editing• Preventing disease before it ever develops

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Artificial intelligence is transforming medicine, but there is one major challenge that doesn't get enough attention.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss how AI models are trained, why scientific literature isn't always perfect, and what that means for the future of drug discovery.

They explore how inaccurate or noisy data can influence AI systems, why reproducibility has become a major issue in scientific research, and the importance of building better datasets before relying on AI to develop the next generation of medicines.

The conversation also highlights why improving the quality of science may be just as important as improving the quality of AI.

Topics covered include:

• Why AI is only as good as the data it learns from• The challenge of noise and reproducibility in science• Building better AI for the future of medicine

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Many of the medicines we rely on today came from unexpected places.

In this episode of the Good Medicine Podcast, Dr. Jeremiah Bearss sits down with Nathan Chow to explore the origins of modern pharmacology and the surprising discoveries that shaped medicine as we know it.

They discuss how the synthetic dye industry played a major role in the development of modern drug discovery, why curiosity has always been one of the most important drivers of scientific progress, and how today's AI tools are helping researchers identify patterns and opportunities that humans may miss.

The conversation also explores the human side of medicine and why remembering where drugs come from helps keep the field grounded in the curiosity and creativity that built it.

Topics covered include:

• The connection between the dye industry and modern pharmacology• How curiosity drives scientific discovery• Why AI may transform the future of drug development

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Modern medicine can do incredible things. But sometimes the best care is knowing when not to intervene.

In this episode of the Good Medicine Podcast, Dr. Jeremiah Bearss sits down with Dr. Amogh Havanur to discuss hospital practices, patient care, and the importance of focusing on the person rather than simply chasing numbers.

They explore why unnecessary overnight interruptions may not always benefit patients, how clinical judgment fits alongside lab values and data, and why getting patients safely back home is often one of the most important goals in healthcare.

The conversation highlights a simple but powerful idea: good medicine is not always about doing more.

Topics covered include:

• Unnecessary interventions in hospital settings• The role of clinical judgment in patient care• Why getting patients home matters

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For years, people have been told to avoid the sun whenever possible. But is completely avoiding sunlight actually healthy?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the role sunlight plays in overall health and why some exposure may be beneficial.

They explore research showing higher all-cause mortality in individuals who avoided sunlight, the connection between sunlight and serotonin, and why seasonal affective disorder may be linked to reduced light exposure.

The conversation also highlights the importance of balance. Too much sun exposure carries risk, but too little may come with consequences as well.

Topics covered include:

• Research on sunlight exposure and mortality• The connection between sunlight and serotonin• Finding the right balance between benefit and risk

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Sleep impacts nearly every aspect of human health.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss why sleep may be one of the most important and overlooked pillars of long-term health.

They explore how poor sleep affects mood, metabolism, cardiovascular risk, obesity, and overall lifespan, as well as the biological consequences of even a single night of sleep deprivation.

The conversation also highlights the importance of taking ownership of personal health through consistent habits like sleep, exercise, and nutrition.

Topics covered include:

• Why sleep impacts mood, lifespan, and metabolic health• How sleep deprivation affects insulin sensitivity• The role of sleep, diet, and exercise in long-term health

🎧 Listen on Spotify and Apple Podcasts📺 Subscribe for more conversations on science, medicine, and innovation.

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