Good Medicine Podcast

Gene editing has long felt like science fiction. Today, it is becoming a clinical reality.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss explore the rapid progress of gene editing and the opportunities and ethical questions that come with it.

They discuss new evidence suggesting that a single treatment may be able to permanently edit genes in the liver to lower cholesterol, the ethical challenges surrounding gene editing in embryos, and why preventing disease before it begins may fundamentally change the future of medicine.

The conversation examines not only what gene editing can do, but also how society should think about using it responsibly.

Topics covered include:

• How gene editing is moving from theory to reality• The ethical questions surrounding embryo gene editing• Preventing disease before it ever develops

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Artificial intelligence is transforming medicine, but there is one major challenge that doesn't get enough attention.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss how AI models are trained, why scientific literature isn't always perfect, and what that means for the future of drug discovery.

They explore how inaccurate or noisy data can influence AI systems, why reproducibility has become a major issue in scientific research, and the importance of building better datasets before relying on AI to develop the next generation of medicines.

The conversation also highlights why improving the quality of science may be just as important as improving the quality of AI.

Topics covered include:

• Why AI is only as good as the data it learns from• The challenge of noise and reproducibility in science• Building better AI for the future of medicine

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Many of the medicines we rely on today came from unexpected places.

In this episode of the Good Medicine Podcast, Dr. Jeremiah Bearss sits down with Nathan Chow to explore the origins of modern pharmacology and the surprising discoveries that shaped medicine as we know it.

They discuss how the synthetic dye industry played a major role in the development of modern drug discovery, why curiosity has always been one of the most important drivers of scientific progress, and how today's AI tools are helping researchers identify patterns and opportunities that humans may miss.

The conversation also explores the human side of medicine and why remembering where drugs come from helps keep the field grounded in the curiosity and creativity that built it.

Topics covered include:

• The connection between the dye industry and modern pharmacology• How curiosity drives scientific discovery• Why AI may transform the future of drug development

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Modern medicine can do incredible things. But sometimes the best care is knowing when not to intervene.

In this episode of the Good Medicine Podcast, Dr. Jeremiah Bearss sits down with Dr. Amogh Havanur to discuss hospital practices, patient care, and the importance of focusing on the person rather than simply chasing numbers.

They explore why unnecessary overnight interruptions may not always benefit patients, how clinical judgment fits alongside lab values and data, and why getting patients safely back home is often one of the most important goals in healthcare.

The conversation highlights a simple but powerful idea: good medicine is not always about doing more.

Topics covered include:

• Unnecessary interventions in hospital settings• The role of clinical judgment in patient care• Why getting patients home matters

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For years, people have been told to avoid the sun whenever possible. But is completely avoiding sunlight actually healthy?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the role sunlight plays in overall health and why some exposure may be beneficial.

They explore research showing higher all-cause mortality in individuals who avoided sunlight, the connection between sunlight and serotonin, and why seasonal affective disorder may be linked to reduced light exposure.

The conversation also highlights the importance of balance. Too much sun exposure carries risk, but too little may come with consequences as well.

Topics covered include:

• Research on sunlight exposure and mortality• The connection between sunlight and serotonin• Finding the right balance between benefit and risk

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Sleep impacts nearly every aspect of human health.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss why sleep may be one of the most important and overlooked pillars of long-term health.

They explore how poor sleep affects mood, metabolism, cardiovascular risk, obesity, and overall lifespan, as well as the biological consequences of even a single night of sleep deprivation.

The conversation also highlights the importance of taking ownership of personal health through consistent habits like sleep, exercise, and nutrition.

Topics covered include:

• Why sleep impacts mood, lifespan, and metabolic health• How sleep deprivation affects insulin sensitivity• The role of sleep, diet, and exercise in long-term health

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GLP-1 drugs have changed the conversation around weight loss, but are they the complete solution?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the benefits and downsides of GLP-1 medications, including how they impact exercise, muscle mass, and long-term weight management.

They explore why many people feel poorly while taking these medications, why that can reduce physical activity, and why exercise remains one of the most important components of healthy weight loss.

The conversation also looks at what happens after stopping GLP-1 therapy and why regaining weight may come with unintended consequences for body composition.

Finally, they discuss AMPK and the idea of developing therapies that could help support the body by mimicking some of the biological signals associated with exercise.

Topics covered include:

• The benefits and drawbacks of GLP-1 medications• Why muscle loss matters during weight reduction• The future of exercise-signaling therapies like AMPK

🎧 Listen on Spotify and Apple Podcasts📺 Subscribe for more conversations on science, medicine, and innovation.

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Drug development takes an average of 15 years, costs billions of dollars, and most therapies still fail before reaching patients.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss one of the biggest problems in modern drug development: animal models that may not accurately predict what happens in humans.

They explore why only a small percentage of therapies that work in mice ultimately succeed in people, how that impacts timelines and costs, and why the industry may need to rethink how therapies are tested.

The conversation also looks at the broader implications for pharmaceutical pricing, innovation, and the future of medicine if more predictive testing systems can be developed.

Topics covered include:

• Why most therapies that work in mice fail in humans• The cost and timeline challenges in drug development• The future of more predictive testing systems

🎧 Listen on Spotify and Apple Podcasts📺 Subscribe for more conversations on science, medicine, and innovation.

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Cancer is being diagnosed in younger people more than ever before.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the growing trend of cancer diagnoses in individuals under the age of 50 and why this shift is raising concern.

They explore data showing increased risk in younger generations, including a significant rise in colon cancer diagnoses compared to previous decades.

The conversation also looks at outcomes, which can be worse for those diagnosed at a younger age, and what this may suggest about when cancer actually begins developing.

This raises an important question. What has changed in recent decades that could be contributing to increased cancer risk in younger populations?

Topics covered include:

• Rising cancer rates in younger generations

• Trends in colon cancer diagnoses under 50

• The importance of early exposure and long-term risk

🎧 Listen on Spotify and Apple Podcasts

📺 Subscribe for more conversations on science, medicine, and innovation.

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The global landscape of drug development is changing rapidly.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the rise of China as a major force in biotech and pharmaceutical innovation.

Over the past several years, China has moved from a relatively small player to one of the most active regions for drug development and major deal-making. By changing how drugs are developed, including speed, cost, and efficiency, Chinese companies are increasingly competing on a global scale.

They explore what this shift means for U.S. biotech companies, the challenges of competing in a faster and more cost-effective system, and how global partnerships are evolving as a result.

The conversation also touches on the pressure facing large pharmaceutical companies, including upcoming patent expirations and the need to replace significant revenue, which may further accelerate global collaboration.

Topics covered include:

• The shift in biotech deal-making toward China• Competitive pressures facing U.S. companies• The impact of patent expirations on global strategy

🎧 Listen on Spotify and Apple Podcasts📺 Subscribe for more conversations on science, medicine, and innovation.

Thank you to our sponsorsBioHive: https://www.biohive.comGalvan: https://galvan.sng.link/D4mh8/oe8k/litt

Follow Good Medicine PodcastInsta: https://www.instagram.com/good.medicine.podcast/X: https://x.com/GoodMedicinePodTikTok: https://www.tiktok.com/@good.medicine.podcastLinkedIn: https://www.linkedin.com/company/goodmedicinepodcast/