GLP-1 drugs have changed the conversation around weight loss, but are they the complete solution?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the benefits and downsides of GLP-1 medications, including how they impact exercise, muscle mass, and long-term weight management.

They explore why many people feel poorly while taking these medications, why that can reduce physical activity, and why exercise remains one of the most important components of healthy weight loss.

The conversation also looks at what happens after stopping GLP-1 therapy and why regaining weight may come with unintended consequences for body composition.

Finally, they discuss AMPK and the idea of developing therapies that could help support the body by mimicking some of the biological signals associated with exercise.

Topics covered include:

• The benefits and drawbacks of GLP-1 medications• Why muscle loss matters during weight reduction• The future of exercise-signaling therapies like AMPK

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Drug development takes an average of 15 years, costs billions of dollars, and most therapies still fail before reaching patients.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss one of the biggest problems in modern drug development: animal models that may not accurately predict what happens in humans.

They explore why only a small percentage of therapies that work in mice ultimately succeed in people, how that impacts timelines and costs, and why the industry may need to rethink how therapies are tested.

The conversation also looks at the broader implications for pharmaceutical pricing, innovation, and the future of medicine if more predictive testing systems can be developed.

Topics covered include:

• Why most therapies that work in mice fail in humans• The cost and timeline challenges in drug development• The future of more predictive testing systems

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Cancer is being diagnosed in younger people more than ever before.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the growing trend of cancer diagnoses in individuals under the age of 50 and why this shift is raising concern.

They explore data showing increased risk in younger generations, including a significant rise in colon cancer diagnoses compared to previous decades.

The conversation also looks at outcomes, which can be worse for those diagnosed at a younger age, and what this may suggest about when cancer actually begins developing.

This raises an important question. What has changed in recent decades that could be contributing to increased cancer risk in younger populations?

Topics covered include:

• Rising cancer rates in younger generations

• Trends in colon cancer diagnoses under 50

• The importance of early exposure and long-term risk

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The global landscape of drug development is changing rapidly.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss the rise of China as a major force in biotech and pharmaceutical innovation.

Over the past several years, China has moved from a relatively small player to one of the most active regions for drug development and major deal-making. By changing how drugs are developed, including speed, cost, and efficiency, Chinese companies are increasingly competing on a global scale.

They explore what this shift means for U.S. biotech companies, the challenges of competing in a faster and more cost-effective system, and how global partnerships are evolving as a result.

The conversation also touches on the pressure facing large pharmaceutical companies, including upcoming patent expirations and the need to replace significant revenue, which may further accelerate global collaboration.

Topics covered include:

• The shift in biotech deal-making toward China• Competitive pressures facing U.S. companies• The impact of patent expirations on global strategy

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A recent study is raising important questions about the relationship between anemia and cancer.

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss new findings from the Karolinska Institute in Sweden that suggest a significant increase in cancer diagnoses shortly after the onset of anemia.

They explore what “incident anemia” means, why iron deficiency is the most common cause, and the many possible reasons someone may become anemic.

The conversation also highlights how to interpret risk. While the relative increase may be high, understanding what that means in absolute terms is critical for context.

This episode breaks down the data, what it may signal, and why changes in the body should not be ignored.

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Brain injury is often misunderstood as damage to neurons alone. The reality is far more complex.

In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Donna Cross to discuss her journey into building a company focused on treating brain-related diseases and the science behind her work.

Dr. Cross shares how a personal connection to Alzheimer’s through a donor to her lab reinforced her commitment to advancing this field and pushed her to take her work beyond academia.

The conversation also explores how brain injury affects multiple systems at once, including the vasculature, the blood-brain barrier, and inflammatory pathways, and why understanding this complexity is critical for developing effective therapies.

Finally, they discuss a broader shift in drug development toward mechanism-based platforms, where therapies are designed to target underlying biological processes rather than a single disease.

Topics covered include:

• The real impact of brain injury beyond neurons• The connection between brain injury and neurodegenerative disease• The shift toward mechanism-based drug development

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Pelvic floor disorders affect millions of women, yet many struggle to find effective treatment.

In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Gabi Niederauer, founder of Freyya, to discuss her journey and the work her team is doing to improve women’s health.

Freyya has developed a device designed to help women perform pelvic floor therapy exercises correctly by providing real-time feedback. Pelvic floor therapy is often prescribed, but many women are unsure if they are doing the exercises properly, which can limit results.

Dr. Niederauer explains the symptoms of pelvic floor disorders, why they are more common than many people realize, and how new technology may help improve outcomes.

This conversation highlights an area of medicine that is often overlooked, despite affecting a significant portion of the population.

Topics covered include:

• The symptoms and prevalence of pelvic floor disorders

• Why pelvic floor therapy can be difficult to perform correctly

• How real-time feedback may improve treatment outcomes

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Freyya:https://www.linkedin.com/company/freyya https://twitter.com/FreyyaInc https://www.instagram.com/freyyainc/ https://www.facebook.com/profile.php?id=61577886342907Dr. Niederauer:https://www.linkedin.com/in/gabriele-niederauer-phd-87365a11/https://www.instagram.com/gabiniederauer/

Peptides are becoming increasingly popular, but how should we actually think about them?

In this episode of the Good Medicine Podcast, Dr. David Bearss and Dr. Jeremiah Bearss discuss how peptides fit into the broader landscape of supplements, drugs, and regulation.

They explore why peptides are often treated more like supplements than pharmaceuticals, what that means for safety and effectiveness, and why not all peptides are created equal.

The conversation also covers the current regulatory environment, how it impacts innovation in medicine, and why there is growing discussion around potential changes.

Finally, they discuss an important safety consideration. Introducing substances into the body through injection bypasses many of the body’s natural protective systems, which is something people should think carefully about.

Topics covered include:

• How peptides compare to supplements and pharmaceuticals

• The role of regulation in safety and innovation

• Key safety considerations when using injectable compounds

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Alzheimer’s disease has long been defined by cognitive decline. But that way of thinking is changing.

In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Brendon Boot from S2N to discuss how the field of Alzheimer’s research has evolved from focusing on symptoms to understanding the underlying changes in the brain.

They explore how this shift is influencing regulators, the importance of earlier intervention, and how new therapies could change the way we approach neurodegenerative disease.

Dr. Boot also shares how S2N is using naturally occurring Alzheimer’s in dogs as a model for clinical development, and why this approach may help accelerate progress toward human therapies.

If early results translate to humans, even partially, this work has the potential to significantly impact how Alzheimer’s is treated in the future.

Topics covered include:

• The shift from symptom-based to biology-based understanding of Alzheimer’s

• Why earlier intervention may be critical for treatment success

• Using naturally occurring disease models to advance clinical research

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NOTE: Dr. Boot misspoke around 22.50. "going to conferences when Leqembi..." he meant to say "going to conferences when Solanezumab...". He requested this get added to the notes for clarity.

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Heart disease remains the leading cause of death worldwide, yet many of the biggest risk factors are preventable.

In this episode of the Good Medicine Podcast, Dr. David Bearss sits down with Dr. Troy Badger from CardioStrong to talk about what actually improves cardiovascular health and what people often get wrong when trying to optimize their health.

They discuss the importance of lifestyle and fitness for reducing cardiovascular risk, the overwhelming amount of health advice circulating on social media, and why simple habits often matter more than complicated protocols.

Dr. Badger shares practical insight from working with patients and athletes on improving long-term health and performance.

Topics covered include:

• Why lifestyle and exercise remain the most powerful tools for heart health• Navigating misinformation in online health advice• The importance of simplicity in maintaining long-term health

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Dr. Badger LinkedIn: https://www.linkedin.com/in/troy-badger-md-1313975/CardioStrong Website: https://sparchealthutah.org/

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