Dr Darren Candow has published over 1000 peer-reviewed studies on creatine, and he's found something surprising: the optimal dose depends entirely on what you're trying to achieve, and it's probably not what you've been taking.

He breaks down why creatine monohydrate is still king despite flashy new forms, which dose actually works for muscle, bone, and brain, and why vegans respond so much better to supplementation.

00:00 Introduction
03:30 Historical perception shifts of creatine
06:18 Personal stories and early experiences with creatine
13:46 Types of creatine and supplement forms
17:18 Monohydrate vs other creatine forms
21:55 Dosing strategies and individual needs
28:17 High doses for sleep deprivation recovery
32:59 Effects of long-term high creatine use
40:22 Does creatine cycling matter?
45:07 Creatine's role in female health
50:23 Supplements that synergise with creatine use
54:02 Potential inhibitors of creatine's effects
57:02 Exercise as an unmatched health tool

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

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Dr Jeremy London is a cardiovascular surgeon who breaks down why blood vessel health matters infinitely more than your heart rate, the ecosystem most cardiologists ignore, and why extreme endurance training and steroids create the exact same cardiac damage. Find out what you can actually change starting tomorrow and why VO2 max isn't the only number worth tracking.

00:00 Introduction
01:20 Broad definition of cardiovascular health beyond just the heart
04:08 Importance of healthy blood vessels in the cardiovascular ecosystem
07:23 Diet and exercise protocols for heart health
16:02 Risks of excessive exercise and muscle growth
20:11 Significance of VO2 Max in assessing cardiovascular efficiency
24:35 The role and accuracy of HRV and wearables
30:29 When to start focusing on heart health and personal anecdote
35:00 Changing perceptions of atherosclerosis as a universal condition
42:50 Personal story of ignoring heart attack symptoms
49:50 Medications and lifestyle changes to manage APOB levels
57:21 Balancing lifestyle choices with cardiovascular risk factors
1:04:30 Impact of family history and lifestyle on heart health
1:09:26 Effects of caffeine and popular cardiovascular myths
1:12:11 Rapid-fire questions about heart health misconceptions

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

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Nathan Carvalho calls himself a human optimisation architect because most people are getting the sequence wrong. He spends weeks connecting the dots between your gut doctor, thyroid doctor, trainer, and nutritionist - people who don't talk to each other but should.

He breaks down why people waste thousands on SS31 and Methylene Blue while missing basic B vitamins and magnesium, how mitochondria are the foundation everything else builds on, and why the body has a specific order of operations most people ignore. Also covers what the first phase of optimisation actually looks like and why it feels terrible before it feels amazing.

00:00 Introduction
05:38 Personal journey and holistic view on human biology
12:01 Major differences between research and real-world application
16:14 The importance of mitochondria in physical goals
24:33 Myths and truths regarding T3 and body function
33:15 T3's comprehensive impact on body performance
41:24 Interaction between testosterone, growth hormone, and T3
45:47 Importance of insulin sensitivity in hormone therapy
50:49 Strategic use of peptides for muscle building and recovery
54:45 Quick-fire questions: trends, overrated peptides, daily habits
57:25 Final thoughts on the significance of circadian rhythms and light exposure
58:54 Closing remarks and where to find more information

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

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Website: https://theoptimizationlab.cc/bio

Latt Mansor has a PhD in physiology from Oxford studying metabolic flexibility, and he discovered something uncomfortable about himself: he was skinny fat at 26% body fat and nothing he did worked until he did the opposite.

He breaks down why 90% of Americans are metabolically inflexible, what exogenous ketones actually do versus what they don't, and why the solution isn't always less, sometimes your body needs more to recognise it's not starving.

00:00 Introduction
04:41 Personal motivation and research journey
08:57 Exploring ketones and ketosis basics
12:09 Measuring ketones: different methods explained
16:02 Importance of metabolic flexibility
19:21 Skinny fat and metabolic inflexibility overview
23:14 Benefits of exogenous ketones
29:27 Surprising effects of ketones on sleep
36:02 Debunking health myths and misinformation
41:14 Personalised diet and wellness strategies

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

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» Produced by Hack You Media: pioneering a new category of content at the intersection of health performance, entrepreneurship & cognitive optimisation.
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Anthony Castore knows peptides better than almost anyone alive, but stacking them without the right foundation nearly killed him. He spent five days in ICU with a breathing tube after trying to optimise himself into oblivion before speaking at Peptide World Congress.

He breaks down the pyramid model most people build upside down, why phase shifts in your cells matter more than which GLP you pick, and how damaged mitochondria can lock you into a metabolic state where nothing works. For people serious about using peptides intelligently.

00:00 Introduction
05:28 Anthony's personal health scare and lesson
12:08 Starting weight loss journey with peptides
21:41 Understanding peptide dosage and timelines
28:47 Addressing hunger and food noise with peptides
33:56 Two peptides and supplements for fat loss
39:50 Exploring ketone monoester benefits
45:09 Looksmaxxing: Peptides for aesthetic improvements
52:11 Peptide use in competitive and bodybuilding contexts
59:08 "Natural" status with peptides
1:02:24 Amplifying your body's natural capabilities with peptides
1:10:42 Health trends and misconceptions
1:12:01 Importance of journaling for mental clarity
1:14:31 Where to find more info from Anthony Castore

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

Hack You Media
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Website: https://www.castoremethod.com/

Dr Sean O'Mara spent years studying visceral fat through MRI scans and discovered the uncomfortable truth: most people have zero awareness they're filled with disease because it doesn't show on the outside. Distance runners look shredded, but their internal scans reveal something shocking.

He breaks down why selection pressure (what actually keeps you alive) got replaced by selection pleasure, and why the three main drivers most people focus on miss the synergy that actually works.

00:00 Introduction
01:02 Dr Sean discusses law and medicine career journey
06:30 Overcoming personal health issues through lifestyle changes
12:00 Realisation of the impact of lifestyle on health
17:18 Specialising in visceral fat due to its health impact
22:40 Discovering ectopic fat in muscles during scans
27:46 Role of diet and lifestyle in reducing visceral fat
31:53 Sprinting vs. distance running in fat reduction
35:00 Tailoring sprinting and dietary approaches for individuals
39:52 MRI insights into muscle mass and fat
43:09 Importance of fermented foods for gut health
50:01 Exploring effects of microbiome on visceral fat
55:59 MRI scans and gut microbiome assessment
1:00:51 Dr Sean's daily diet and lifestyle habits
1:06:30 Final advice: Stop processed foods, start fermented foods

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

Hack You Media
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» Produced by Hack You Media: pioneering a new category of content at the intersection of health performance, entrepreneurship & cognitive optimisation.
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Siim Land reversed his biological age from 31 to low double digits, but he's not obsessing over the metrics most people focus on.

He explains which genes actually matter for longevity, why blood markers tell a better story than genetics, and the surprising way health anxiety is sabotaging your results. Also covers why measuring everything can create the problem you're trying to avoid.

00:00 Introduction
04:06 Genetics vs. environment in determining longevity risks
10:24 Importance of regular blood work in preventive health
14:05 Misconceptions in longevity and the role of genetic therapies
18:20 Health anxiety and its impact on mental and physical health
21:44 Bryan Johnson's lifestyle and discovery of autoimmune issues
28:19 Calorie intake vs. quality of food for health outcomes
33:08 Impacts of meal timing and fasting on lifespan
39:43 Top recommended supplements and their significance
44:24 Discussion on glycine supplementation and dosage
48:52 Overrated supplements in the longevity space
52:40 Critique of popular health trends like the Italian lifestyle
55:05 Everyday habits Siim doesn't obsess over
57:10 Siim's recommended health hack for overall improvements

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

Hack You Media
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Website: https://www.skool.com/top1health/

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Stan Efferding spent decades coaching weight loss clients, and the science is clear: your body actively resists fat loss by increasing hunger hormones, making it a biological problem, not a willpower issue.

The Vertical Diet is systematic, calorie deficit, adequate protein for hunger control, minimum healthy fats, and then carbs chosen for satiety. Boiled potatoes beat everything for keeping you full, especially if you cool them overnight to create resistant starch that feeds your gut. Training matters infinitely more than diet optimisation, and most people skip it entirely. Only creatine and caffeine are worth supplementing. Internet obsession with glucose spikes and CGM monitoring is noise, distracting from the actual problem: hyper-palatable, cheap foods engineered to make you overeat. Fix your environment and hunger first, not the details.

00:00 Intro
03:12 Stan's background as a skinny kid turned professional bodybuilder
11:20 Deficiencies hidden in restrictive diets and the female athlete triad
14:24 Red meat, dairy and the 1.6g protein consensus broken down
19:30 White rice as an energy tool
27:48 White rice vs brown rice
33:48 Satiety index potato swaps and practical tools to beat hunger
37:47 Pre-workout nutrition and why training intensity beats everything else
43:00 Caffeine, perceived effort and the psychology of pushing past failure
48:21 Overrated trends, seed oils and bro science debunked
53:00 How misinformation spreads and the value of staying academically honest
01:01:38 The Shark Tank experience
01:08:53 Life in American Samoa and running an online business
01:10:41 The one hack: sleep apnea resolution

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

Hack You Media
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Instagram: https://www.instagram.com/mikethurston/?hl=en
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Website: https://stanefferding.com/

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The mitochondrial stack that changed bodybuilding, and why brain damage from compounds can't be undone.

Dean created a stack (Motzi, SLUPP, Methylene Blue) after fixing his gut issues and realising optimised metabolism meant he never needed to starve during prep, calories in/calories out ignores actual metabolic efficiency. Most people don't realise compounds that spike dopamine permanently fry your brain's reward system, leaving guys with normal testosterone but zero libido because their dopamine receptors are damaged. Teenagers now skip the basics and jump straight to peptides, thinking it shortens years of work, but that's where irreversible harm happens.

00:00 Introduction
01:28 Starting from scratch and moving to a new city
04:00 Leaving a secure job for passion
08:30 Personal health challenges and breakthroughs
12:05 Creating an energy-boosting supplement stack
17:20 Psychological impact of extreme dieting in bodybuilding
22:30 Balancing nutrient intake for optimal brain function
26:40 Addressing dopamine and libido post-steroid cycles
31:00 The rise and influence of peptide use in fitness
35:10 Impact of social media on health trends and youth
40:10 Longevity vs muscle mass: navigating trade-offs
45:20 The complex nature of obesity beyond diet
48:50 Utilities and drawbacks of GLP-1 usage in weight loss
54:30 Hair loss treatments: options and myths
58:30 Testosterone replacement therapy: next steps and pitfalls
1:04:00 The interplay of mental health and supplements
1:08:45 Managing oxidative stress for better health
1:13:20 Developing a balanced approach: gains vs health risks

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

Hack You Media
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Dr Tyler Panzner joins us for a discussion on genetic testing, why your supplements clash, and why diet trends are wrong for you.

Genetic testing is accurate, but most panels are overhyped marketing, interpretation matters more than the test itself.

Most people take multiple supplements without knowing they clash together and cancel each other out or cause side effects. Methylated vitamins don't work for everyone, and carnivore, keto, and vegan diets are short-term tools, not permanent solutions. What works depends on your genetics and your ancestry. Figure out your actual genes instead of following influencers selling the same diet to everyone.

00:00 Introduction
02:42 Personal journey into precision medicine and genetics
05:46 Transition from academia to personalised medicine
09:53 Reliability of genetic testing and its interpretation
19:03 Genetic testing alongside regular blood panels
26:30 Risks of supplements interacting negatively with genetics
30:20 Permanent insights from genetic testing
38:12 COMT gene's influence on stress and behaviour
42:40 The complexity of diet, genetics, and health trends
47:37 Genetics' role in diet and lifestyle choices
57:41 Genetic insights for exercise recovery and performance
01:02:47 Considering peptides and their genetic interactions

DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.

Hack You Media
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