Healio Minute

In this edition, FDA votes to support approval of ALS therapy; partnership offers military veterans access to psychedelics; epidural steroid injections as alternate pain management options and more.

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FDA advisory committee votes to support approval of ALS therapy

Partnership offers military veterans access to psychedelics at home, abroad

Epidural steroid injection an alternate pain management option

Ketamine may be effective in treating children with ADNP syndrome

FDA accepts new drug application for Rett syndrome treatment

References:

Christo PJ. Landscape of wonders: Injections, nerve blocks, pumps and neuromodulation. Presented at: PAINWeek; Las Vegas; Sept. 9-12, 2022.

Kolevzon A, et al. HGG Adv. 2022;doi:10.1016/j.xhgg.2022.100138.

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In this edition, new cannabinoids hold promise for medical applications; Theranica secures $45 million for migraine treatment device and more.

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Newly discovered cannabinoids hold promise for medical, pain applications

Theranica secures $45 million to expand wearable migraine treatment device in US

Implantable loop recorder screening for AF not linked to stroke reduction risk

Survey shows OTC pain relievers remain 'common, valuable'

Amneal submits new drug application for extended-release Parkinson's treatment

References:

Diederichsen SZ et al. JAMA Neurol. 2022;doi:10.1001/jamaneurol.2022.3031.

Guglieri M et al. JAMA Neurol. 2022;doi:10.1001/jamaneurol.2022.2480.

Jacknin J. How green is my valley: Newly discovered cannabinoids and their possible medical uses. Presented at: PAINWeek; Las Vegas; Sept. 6-9, 2022.

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In this edition, germline testing 'should be considered' for all patients with lung cancer; phase 3 trial of canakinumab misses endpoint; sexual dysfunction common among women with lung cancer, and more.

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Germline testing 'should be considered' for all patients with lung cancer, data suggest

Phase 3 trial of canakinumab for non-small cell lung cancer misses endpoint

Sexual dysfunction common among women with lung cancer

Younger patients with lung cancer more likely to have advanced disease at diagnosis

Sotorasib extends PFS in lung cancer subset

References:

Florez N, et al. Abstract MA14. Presented at: International Association for the Study of Lung Cancer World Conference on Lung Cancer (hybrid meeting); Aug. 6-9, 2022; Vienna.

Potter A, et al. Abstract OA05. Presented at: International Association for the Study of Lung Cancer World Conference on Lung Cancer (hybrid meeting); Aug. 6-9, 2022; Vienna.

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Sorscher S, et al. Abstract 388570. Presented at: ASCO Plenary Series (virtual); Aug. 16, 2022.

In this episode, VTE rate with abemaciclib (uh-bem-uh-cy-clib) higher in real-world setting; Enhertu extends progression-free survival in patient subgroup; FDA grants priority review to elacestrant (ee-las-cess-trant) for metastatic disease; and more.

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VTE rate with abemaciclib higher in real-world setting among patients with breast cancer

Enhertu extends progression-free survival in breast cancer subgroup, topline data show

FDA grants priority review to elacestrant for metastatic breast cancer

Lack of financial comfort linked to weight gain among young breast cancer survivors

Hispanic ethnicity often not reported in breast cancer studies

References:

Bazan JG, et al. JAMA Oncol. 2022;doi:10.1001/jamaoncol.2022.3527.

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Sella T, et al. Cancer. 2022;doi:10.1002/cncr.34342.

Watson NW, et al. Cancer. 2022.doi:10.1002/cncr.34367.

In this edition, blood-based concussion diagnostic tool gets patent; examining the brain's electrical signals may be key to treating epilepsy, schizophrenia; machine-learning model may predict best antiseizure medications and more.

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Neurolytixs secures US patent for blood-based concussion diagnostic tool

Examination of brain's electrical signals may be key to treating epilepsy, schizophrenia

Machine-learning model may predict which antiseizure medications work best

Rafa receives FDA approval for autoinjector to treat status epilepticus in adults

Aptinyx completes enrollment of phase 2 trial for oral cognitive impairment treatment

References:

Hakeem H, et al. JAMA Neurol. 2022;doi:10.1001/jamaneurol.2022.2514.

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In this edition, BMI is associated with dementia in women and linked with disease in men; Healthy diet, physical activity are linked to lower mortality in adults with PD; mild TBI and CT scans and more.

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High BMI negatively associated with dementia in women, low BMI linked with disease in men

Healthy diet, physical activity linked to lower mortality rate in adults with PD

Patients with mild TBI, negative CT scan should be evaluated 2 weeks after injury

FDA approves spinal cord stimulation system for broad treatment of chronic pain

Artificial intelligence model detects Parkinson's disease via nocturnal breathing signals

References:

Jacob L, et al. J Alzheimers Dis. 2022;doi:10.3233/JAD-220147.

Madhok DY, et al. JAMA Netw Open. 2022;doi:10.1001/jamanetworkopen.2022.23245.

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Yang Y, et al. Nat Med. 2022;doi:10.1038/s41591-022-01932-x.

Zhang X et al. JAMA Netw Open. 2022;doi:10.1001/jamanetworkopen.2022.27738.

In this edition, macular retinal nerve fiber layer thickness linked with cognitive decline; FDA approves Lucentis biosimilar; advanced visual field loss risk higher after glaucoma diagnosis in Black patients; and more.

Association found between macular retinal nerve fiber layer thickness, cognitive decline

FDA approves Cimerli as interchangeable biosimilar to Lucentis

Black patients have higher risk for advanced visual field loss after glaucoma diagnosis

iStent infinite cleared by FDA

Alcon to acquire Aerie Pharmaceuticals

References:

Kang JH, et al. Transl Vis Sci Technol. 2022;doi:10.1167/tvst.11.7.21.

Kim HM, et al. JAMA Ophthalmol. 2022;doi:10.1001/jamaophthalmol.2022.1563.

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In this edition, leisure activities may lower risk for Alzheimer's disease and dementia; most common long COVID symptoms include fatigue and headache; 'life-changing' app-based digital therapeutic for tinnitus and more.

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Leisure activities may lower risk for Alzheimer's disease, dementia

Fatigue, headache most common long COVID symptoms

Personalized, app-based digital therapeutic for tinnitus 'life-changing'

NIH to fund development, testing of robots to aid in Alzheimer's disease care

AI algorithm detects brain abnormalities, could help treat epilepsy

References:

Chen AK, et al. Brain Behav Immun. 2022;doi:10.1016/j.bbih.2022.100491

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Searchfield GD, et al. Front Neurol. 2022;doi:10.3389/fneur.2022.958730

Spitzer H, et al. Brain. 2022;doi:10.1093/brain/awac224

Su S, et al. Neurology. 2022;doi:10.1212/WNL.0000000000200929

In this edition, light stimulation may help delay Alzheimer's progression; sleep EEGs may predict future disease and mortality; updated data on the prevalence of tinnitus and more.

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Light stimulation may help delay AD progression, more research needed in older adults

Sleep EEGs may predict future disease, mortality

Tinnitus affects more than 740 million adults globally

Gut-based neurotoxin triggers inflammation associated with Alzheimer's disease

CSF biomarkers support AD diagnosis in nearly 90% of clinical cases

References:

Agüero P, et al. CSF Alzheimer's biomarkers in clinical practice. Presented at: Alzheimer's Association International Conference; July 31-Aug. 4; San Diego.

Beckers E, et al. Characterization of pupillary responses to alternating blue and orange light exposures in a fMRI protocol. Presented at: Alzheimer's Association International Conference; July 31-Aug. 4; San Diego.

Jarach CM, et al. JAMA Neurol. 2022;doi:10.1001/jamaneurol.2022.2189.

Pogue AI, et al. Front Neurol. 2022;doi:10.3389/fneur.2022.900.048

Sun H, et al. Predicting incident outcomes from the microstructure of sleep. Presented at: SLEEP; June 5-8, 2022; Charlotte, N.C.

In this edition, lung cancer risk is high among smokers for whom screening is not recommended; the role of circulating tumor DNA in lung cancer detection and treatment is 'exciting' for field; a subset of patients with lung cancer have poor response to COVID-19 vaccines, and more.

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Lung cancer risk high among smokers for whom screening is not recommended

Role of circulating tumor DNA in lung cancer detection, treatment 'exciting' for field

Subset of patients with lung cancer have poor response to COVID-19 vaccines

Low area-level income, education linked to higher odds of late-stage lung cancer diagnosis

Phase 3 trial of Onivyde for small cell lung cancer misses endpoint

References:

Faselis C, et al. JAMA Oncol. 2022;doi:10.1001/jamaoncol.2022.2952.

Gupta A, et al. Cancer. 2022;doi:10.1002/cncr.34327.

Healio Interview

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Valanparambil RM, et al. J Clin Oncol. 2022;doi:10.1200/JCO.21.02986.