Healio Minute

In this edition, physicians should question patients with restless leg syndrome about cannabis use ; digital therapeutic improves symptoms of insomnia, anxiety and depression; more efficient sleep may benefit patients with fibromyalgia and insomnia and more.

Read the full coverage here:

Physicians should question patients with restless leg syndrome about cannabis use

Digital therapeutic improves symptoms of insomnia, anxiety, depression for 6 months

More efficient sleep may benefit patients with fibromyalgia, insomnia

FDA accepts new drug application, grants priority review for ALS treatment

Quanterix announces validation of biomarker detection test to aid in diagnosis of AD

References:

Kachechian T, et al. Prevalence of cannabis use in patients with restless leg syndrome for symptomatic relief. Presented at: SLEEP; June 5-8, 2022; Charlotte, N.C.

Nair N, et al. Effect of sleep on the relationship between pain-related disability and neural correlates of pain processing in adults with fibromyalgia and insomnia. Presented at: SLEEP; June 5-8, 2022; Charlotte, N.C.

Press Release

Press Release

Press Release

In this episode, menopausal hormone therapy is not associated with breast cancer recurrence and mortality; pandemic-related screening declines may result in 'increased avoidable cancer deaths'; data on pertuzumab regimen in early breast cancer; and more.

Read the full coverage here:

Menopausal hormone therapy not associated with breast cancer recurrence, mortality

Screening declines after pandemic onset may result in 'increased avoidable cancer deaths'

Updated data show long-term benefit with pertuzumab regimen in early breast cancer

Medical financial hardship linked to increased mortality risk among cancer survivors

FDA grants priority review to Enhertu for HER2-low metastatic breast cancer

References:

Cold S, et al. J Natl Cancer Inst. 2022;doi:10.1093/jnci/djac112.

Press Release

Press Release

Teglia F, et al. JAMA Oncol. 2022;doi:10.1001/jamaoncol.2022.2617.

Yabroff KR, et al. J Natl Cancer Inst. 2022;doi:10.1093/jnci/djac044.

In this edition, temperature-controlled mattresses and pillows improve sleep; how overturning Roe v. Wade affects the field of neurology; college students' cognition altered by changing sleep patterns and more.

Read the full coverage here:

Temperature-controlled mattress, pillow improve sleep onset, quality

Decision to overturn Roe v. Wade will 'undoubtedly' affect those in the field of neurology

Changing sleep patterns affect cognition in college students

FDA grants tentative approval for daytime sleepiness treatment

Study shows people with migraines have lower risk for sleep apnea

References:

Costa A, et al. Daily patterns of sleep and metacognition in college students. Presented at: SLEEP; June 5-8, 2022; Charlotte, N.C.

Gruenthal E, et al. Polysomnographic biomarkers of sleep disruption and sleep disordered breathing in migraine: A large matched case control clinical registry-based study. Presented at: SLEEP; June 5-8, 2022; Charlotte, N.C.

Haghayegh S, et al. J Sleep Res. 2022;doi:10.1111/jsr.13662.

LaHue SC, et al. JAMA Neurol. 2022;doi:10.1001/jamaneurol.2022.2347.

Press Release

In this week's edition, a Labcorp blood test identifies signs of neurodegenerative disease; the FDA approves an oral treatment for partial seizures in teens; ketamine shows efficacy in epilepsy; and more.

Read the full coverage here:

Labcorp blood test identifies signs of neurodegenerative disease

FDA approves oral treatment for partial seizures in patients aged 16 years and older

Ketamine effective treatment for neonatal, pediatric epilepsy

FDA places hold on phase 2/3 clinical trial of stroke therapy

Hypertension, obesity, physical inactivity among highest risk factors for dementia

References:

Jacobwitz M, et al. Neurology. 2022;doi:10.1212/WNL.0000000000200889.

Lee M, et al. JAMA Netw Open. 2022;doi:10.1001/jamanetworkopen.2022.19672.

Press Release

Press Release

Press Release

In this week's edition, Break Through Cancer awards $50M to fund a 'radical collaboration' in cancer research; the FDA grants a breakthrough device designation for an MS plasma test; App-based mental exercises may improve cognitive impairment; and more.

Read the full coverage here:

Break Through Cancer awards $50M to fund 'radical collaboration' in cancer research

FDA grants breakthrough device designation for MS plasma test

App-based mental exercises improve cognitive impairment

Neurodevelopment in infants with CHD may be predicted in utero

Benefits of ticagrelor, aspirin for stroke outweigh risks over 30 days

References:

Press Release

Press Release

Press Release

Healio Interview

Wang Y, et al. Neurology. 2022;doi:10.1212/WNL.0000000000200355.

In this edition, Iveric Bio is given exclusive permission to develop, commercialize new formulations of Zimura; subretinal drusenoid deposits linked with cardiovascular disease; subcutaneous elamipretide may improve visual function in geographic atrophy; and more.

Read the full coverage here:

Iveric Bio given exclusive permission to develop, commercialize new formulations of Zimura

Subretinal drusenoid deposits linked with cardiovascular disease

Subcutaneous elamipretide may improve visual function in geographic atrophy

Combination technique useful for treating myopic traction maculopathy

Insufficient treatment common among patients with wet AMD

References:

Barikian A, et al. Characteristics and outcomes of patients with nAMD managed in US routine clinical practice: An analysis of the IRIS Registry database. Presented at: American Society of Retina Specialists annual meeting; July 13-16, 2022; New York.

Chew FM, et al. Scleral imbrication with combined pars plana vitrectomy and foveal sparing ILM peel as a useful surgical modality in treating myopic traction maculopathy. Presented at: American Society of Retina Specialists annual meeting; July 13-16, 2022; New York.

Heier JS. ReCLAIM-2 study results: A phase 2 study of elamipretide safety & efficacy in geographic atrophy. Presented at: American Society of Retina Specialists annual meeting; July 13-16, 2022; New York.

Press Release

Thompson RJ, et al. Retina. 2022;doi:10.1097/IAE.0000000000003460.

In this edition, Incidental respiratory findings on low-dose CT lung cancer screening common; lack of guideline-concordant treatment for early-stage non-small cell lung cancer common; women at greater risk for more severe adverse events from cancer treatments, and more.

Read the full coverage here:

Incidental respiratory findings on low-dose CT lung cancer screening common

Lack of guideline-concordant treatment for early-stage non-small cell lung cancer common

Women at greater risk for more severe adverse events from cancer treatments

Visual, quantitative CT emphysema assessments linked to higher odds of lung cancer

Acetaminophen may reduce immunotherapy efficacy in patients with cancer

References:

Bessede A, et al. Abstract LBA12000. Presented at: ASCO Annual Meeting; June 3-7, 2022; Chicago.

Kehl KL, et al. JAMA Oncol. 2022;doi: 10.1001/jamaoncol.2022.0039.

Pinsky PF, et al. Chest. 2022;doi:10.1016/j.chest.2021.11.015.

Unger JM, et al. J Clin Oncol. 2022;doi:10.1200/JCO.21.02377.

Yang X, et al. Radiol. 2022;doi:10.1148/212904.

In this week's edition, women are less likely than men to return to work after large vessel occlusion stroke; cognitive impairment, headaches and CVD are more common in former college football players; veterans, providers support the addition of integrative medicine for chronic headaches; and more.

Read the full coverage here:

Women less likely than men to return to work after large vessel occlusion stroke

Cognitive impairment, headaches, CVD more common in former college football players

Veterans, providers support addition of integrative medicine for chronic headaches

New blood biomarker may lead to early diagnosis of frontotemporal dementia

Phase 2 trial shows promising results for oral Parkinson's treatment

References:

Hahn M, et al. Stroke. 2022;doi:10.1161/STROKEAHA.121.037386.

Phelps A, et al. JAMA Netw Open. 2022;doi:10.1001/jamanetworkopen.2022.8775.

Press Release

Press Release

Press Release

In this edition, late-stage colorectal, breast cancer diagnoses increase after start of COVID-19 pandemic; chemicals found in hair products increase viability of breast cancer cells in Black women; continued CDK 4/6 inhibition after breast cancer progression may benefit some patients; and more.

Read the full coverage here:

Late-stage colorectal, breast cancer diagnoses increase after start of COVID-19 pandemic

Chemicals found in hair products increase viability of breast cancer cells in Black women

Continued CDK 4/6 inhibition after breast cancer progression may benefit some patients

Some older women with luminal A breast cancer can safely forgo radiotherapy, study shows

Sacituzumab govitecan significantly extends PFS in advanced breast cancer subset

References:

Zhou JZ, et al. JAMA Netw Open. 2022;doi:10.1001/jamanetworkopen.2021.48581.

Trevino L, et al. RF22 | PMON05. Presented at: ENDO Annual Meeting; June 11-14, 2022; Atlanta (hybrid meeting).

Kalinsky K, et al. Abstract LBA1004. Presented at: ASCO Annual Meeting; June 3-7, 2022; Chicago.

Source: Whelan TJ, et al. Abstract LBA501. Presented at: ASCO Annual Meeting; June 3-7, 2022; Chicago.

Rugo HS, et al. Abstract LBA1001. Presented at: ASCO Annual Meeting; June 3-7, 2022; Chicago.

In this week's edition, CAR-T 'robustly effective' in younger patients with deadly form of brain cancer; SARS-CoV-2 linked to range of neurological diseases; Increased mortality risk for men with type 1 diabetes, regardless of cognitive ability; and more.

Read the full coverage here:

Steerable microcatheter nets FDA 510(k) clearance for neurologic, peripheral, coronary use

CAR-T 'robustly effective' in younger patients with deadly form of brain cancer

SARS-CoV-2 linked to range of neurological diseases

Risk for major adverse CV events elevated with type 2 diabetes, cognitive impairment

Increased mortality risk for men with type 1 diabetes, regardless of cognitive ability

References:

Press Release

Majzner RG, et al. Abstract CT001. Presented at: American Association for Cancer Research Annual Meeting; April 8-13, 2022; New Orleans.

Klein RS, et al. Neurobiology of COVID-19. Presented at: American Academy of Neurology annual meeting; April 2-7, 2022; Seattle.

Cukierman-Yaffe T, et al. J Clin Endocrinol Metab. 2022;doi:10.1210/clinem/dgac200

Dybjer E, et al. Diabet Med. 2022;doi:10.1111/dme.14806.