Charlotte Moon was born in 1840 to a plantation-owning family in Virginia, in the pre-Civil War southern culture depicted in Gone with the Wind. After a youthful rebellion against Christianity, she was converted in 1859. A woman well under five-foot in height, Lottie spent the Civil War helping her widowed mother manage the estate and teaching in schools.

Lottie felt called to be an evangelist and church planter. However, her mission’s policy prohibited a woman from preaching to groups which included men. Never one to suffer quietly, Lottie began writing letters and articles, many of which found their way back to the United States. Pointing out the shortage of missionaries and the extraordinary evangelistic opportunities available in China, Lottie pressed for women to be allowed to use any gifting they had for evangelism or preaching.