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HNMT is the overlooked enzyme that handles internally-produced histamine in your brain, liver, and nervous system while DAO manages dietary histamine. Many histamine intolerance sufferers experience symptoms despite following a low-histamine diet because their HNMT enzyme is overwhelmed by stress, hormones, or environmental triggers.
• HNMT and DAO work differently – DAO breaks down external histamine from foods while HNMT processes internal histamine
• Internal histamine comes from stress, hormones, immune responses, and environmental triggers
• HNMT symptoms include extreme fatigue, sensitivity to fragrances, paradoxical reactions to relaxing activities, hormonal migraines, and anxiety
• Supporting HNMT requires healing your gut, eating methylation-supporting foods (B12, folate, magnesium, choline)
• Lowering chronic stress load through breath work, therapy, and nervous system regulation is crucial
• Avoiding fragrances and toxins reduces the burden on your HNMT enzyme
• Histamine metabolism improves when addressing the whole picture: gut health, inflammation, stress, nourishment and rest
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