During the fierce persecution of Christians by the Persian King Shapur II, Saint Sadoth succeeded the Martyr Symeon (April 17) as Bishop of Seleucia. His name in Persian, Shah-dost, means 'Friend of the King'; but the earthly Shah saw him as no friend, and the holy bishop knew that his days on earth were numbered. One night in a dream, Sadoth saw a ladder reaching from earth to heaven. At the top stood Bishop Symeon, who called joyfully to him: 'Climb up, Sadoth, and do not be afraid! I climbed up yesterday; you will climb up today.' Waking, Sadoth knew that he would soon be called to martyrdom. He immediately set out to encourage his flock and to exhort them to stand firm for Christ in the coming day of persecution.

A few days later the persecutors came in the King's name to arrest the holy Bishop; with him they seized 128 priests, deacons, monks and simple believers. All were held in prison for five months, being brought forth repeatedly and tortured in ways too cruel to describe; but not a single one could be brought to worship the sun. Finally, all were condemned to die by the sword. The 128 martyrs, chained together, sang joyous hymns as they went to the place of execution. They did not cease to sing until the death of the last Martyr. Sadoth himself, however, was taken in chains to the city of Beit Lapat, where he was beheaded a few days later.