A pagan couple, Cleitophon and Leucippe, who lived in Emesa in the reign of the Emperor Decius, were grieved that they were unable to have children. One day a monk named Onuphrius came to their door seeking alms to give to the poor, and seeing Leucippe's downcast face, asked her what was wrong. When she replied that she was barren, Onuphrius told her that this was by God's providence, to prevent their child from being given over to idolatry, and that if they accepted Christ she would bear a child. Leucippe was baptized into the Faith and bore a son not long after, which in turn brought her husband to faith in Christ. The son was named Galaction in baptism.

Years later, Galaction's father, now widowed, decided that Galaction should marry a pagan maiden named Episteme. Galaction married out of obedience, but would not approach Episteme's bed since she was a pagan. In time, he convinced her of the truth of the Faith and baptised her himself. Not long after she was told in a dream of the glory that awaits those who consecrate themselves wholly to God. When she told her husband of the dream, they both resolved to remain in virginity, settling in separate monastic communities near to one another.

In one of the Emperor's persecutions of Christians, Galaction was seized by imperial soldiers and taken away to be killed. Episteme, told in a vision of his arrest, asked the blessing of her abbess to join him in martyrdom. Receiving it, she hurried to Galaction's place of imprisonment, boldly announced her faith in Christ, and after many tortures and humiliations husband and wife were beheaded together.