The ImmunoVerse™

Hot vs. Cold Tumors: Decoding the Tumor Microenvironment, ft. Dr. Thomas Gajewski


Listen Later

Dr. Patrick Hwu sits down with Dr. Thomas Gajewski, a leader in tumor immunology at the University of Chicago. Dr. Gajewski discusses his pioneering work defining “hot” versus “cold” tumors — an insight that transformed how immunotherapists understand tumor response. The conversation dives into how the tumor microenvironment, patient genetics and even the gut microbiome shape immune activity in cancer. His work continues to drive strategies to turn cold tumors into responsive ones, giving new hope to patients across all cancer types. 

What You’ll Learn from Dr. Gajewsk

  • Origins of the hot vs cold tumor concept and its impact on immunotherapy.
  • How checkpoint inhibitors revive immune responses in T-cell–infiltrated (“hot”) tumors.
  • Challenges of cold tumors and strategies to convert them into hot, immune-responsive tumors.
  • Pioneering work linking the gut microbiome to immunotherapy response.
  • The significance of interdisciplinary research, from tumor genetics to immunology.Humanizing science: the role of music and culture in building community and sustaining belief.
  • Access more show notes, links and transcript here: https://www.moffitt.org/about-moffitt/podcasts/immunoverse/hot-vs-cold-tumors/

    ...more
    View all episodesView all episodes
    Download on the App Store

    The ImmunoVerse™By Moffitt Cancer Center

    • 5
    • 5
    • 5
    • 5
    • 5

    5

    27 ratings


    More shows like The ImmunoVerse™

    View all
    This American Life by This American Life

    This American Life

    90,956 Listeners

    Radiolab by WNYC Studios

    Radiolab

    44,008 Listeners

    The Dave Chang Show by The Ringer

    The Dave Chang Show

    8,367 Listeners

    The Megyn Kelly Show by SiriusXM

    The Megyn Kelly Show

    40,787 Listeners