In House on Fire, William H. Foege recounts the remarkable global effort to eradicate smallpox, one of history’s deadliest diseases. Drawing from his personal experiences as a public health leader, Foege provides an inside look at the challenges, breakthroughs, and strategies that led to the successful eradication of smallpox in 1980. This episode delves into Foege’s inspiring account of collaboration, innovation, and determination, offering lessons on what it takes to overcome seemingly insurmountable global health challenges.