March 14, 2024

How to Grow your Mitochondria with Exercise? | #40 ft. Dr. Robert A. Jacobs

1 hour 12 minutes

This episode of the Critical Oxygen podcast explores the adaptation of mitochondria to exercise. I am joined by Dr. Robert Jacobs where we discuss topics such as the variability in measurements, challenges of wet lab work, dispelling the myth of mitochondrial biogenesis, different populations of mitochondria, hypertrophy of slow twitch fibers, the role of AI in education, and the importance of search engine optimization in research. This conversation explores the remodeling and functional changes that occur in mitochondria in response to exercise. It discusses how mitochondria adapt by adding folds (cristae) and forming super complexes to improve efficiency and electron transfer.

Primary paper of discussion - https://pubmed.ncbi.nlm.nih.gov/26440213/

TAKEAWAYS

1) Mitochondria adapt to fit the energetic needs of muscle cells, forming a network of reticular channels throughout the muscle.

2) There is variability in measurements such as heart rate and lactate, which should be considered when interpreting results - https://pubmed.ncbi.nlm.nih.gov/36866970/

3) Mitochondrial biogenesis is a myth, as mitochondria actually expand and build upon existing networks to meet energy demands.

4) Mitochondria remodel and undergo functional changes in response to exercise, adding folds and forming super complexes to improve efficiency and electron transfer.

5) Temperature plays a role in mitochondrial adaptations, with mitochondria potentially getting 10-15 degrees hotter than the surrounding cell.

6) Exercise intensity affects mitochondrial adaptations, with high-intensity exercise preferentially increasing mitochondrial function and low-intensity exercise promoting mitochondrial volume.

Enjoy!

Enjoying these podcasts? Don't forget to subscribe to get notified when new episodes are released.

If you have a question or topic you want us to address, leave a comment!

Follow Phil on Instagram - https://www.instagram.com/criticalo2

Interested in testing, courses, or other long form content check out the critical oxygen website - https://www.criticaloxygen.com

OUTLINE

00:00 Introduction to Mitochondria and Muscle Fiber Adaptation

06:14 Variability in Measurements

10:55 Challenges of Wet Lab Work

14:09 Dispelling the Myth of Mitochondrial Biogenesis

26:12 Mitochondrial Adaptation to Exercise

34:07 Different Populations of Mitochondria

36:03 Hypertrophy of Slow Twitch Fibers

46:17 The Role of AI in Education

49:15 The Importance of Search Engine Optimization in Research

50:40 Remodeling and Functional Changes in Mitochondria

57:19 Continual Functional Changes and Expansion

59:16 Mitochondrial Heat Dissipation

01:05:48 Effects of Exercise Intensity on Mitochondrial Adaptations

01:08:41 The Influence of Temperature on Fatigue and Adaptation

01:09:40 Homeostatic Perturbations that Stimulate Adaptation

01:11:31 Closing Remarks

...more

View all episodes

By Philip Batterson, Ph.D.

1313 ratings