Conversation with Prof. Scott L. Friedman [Mount Sinai School of Medicine, New York]
https://diagnosticdetectives.com/liver/friedman/
Causes, diagnosis, treatment of NAFLD and NASH. Genetic tests. Supplements and generic drugs for NASH. Liver cancer risk. Coffee helps liver health. On importance of having a good mentor.
00:00 Biography: Liver expert, Prof. Scott L. Friedman
01:33 What is Fatty Liver Disease [NAFLD]?
04:17 Non-obese patients with NAFLD.
05:29 Diagnostic tests for NAFLD.
06:31 Normal ALT, AST but bad NASH or NAFLD
07:40 FibroScan, MR Elastography to test for liver fibrosis
08:18 Can NAFLD be reversed?
09:34 How NASH differs from NAFLD?
10:16 What drives progression to NASH?
11:40 Genetic tests for risks of liver disease?
12:33 Microbiome and NAFLD / NASH?
14:09 Antibiotics in food lead to NAFLD / NASH.
16:06 ‘Auto-brewery syndrome’: gut makes alcohol?
17:56 Fecal microbiome transplantation for NASH?
20:29 Supplements and generics for NASH
20:48 Pharma is not interested in generics or supplements for NASH.
22:27 Hepatic Stellate Cells cause NAFLD / NASH?
28:30 Liver cancer and NASH / NAFLD?
32:03 How to personalize liver cancer screening in NASH?
34:27 Why no drugs approved for NASH?
38:28 Leading drug candidates for NASH therapy.
42:38 Repurposing generics for NASH therapy.
44:06 Statins for NASH and Heart risks?
45:00 Most NASH / NAFLD patients have NO symptoms
46:15 Coffee and liver health?
46:45 Coffee reduces risks of liver disease
48:13 Future of liver disease treatment.
49:56 Xenotransplantation for liver disease
51:15 Regeneration of liver: greatest mystery!
52:17 Questions of patients with liver disease.
53:51 ‘No symptoms but advanced liver disease’
54:12 How to improve liver health?
54:30 Weight loss is best therapy for NASH / NAFLD
55:22 Patients’ fear: no symptoms but bad liver disease?
55:54 Alcohol rarely causes NAFLD / NASH
56:42 ‘Mentorship is key to successful career’ - Prof. Friedman
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