Translating Aging

"How We Age: The Science of Longevity" (Professor Coleen Murphy, Princeton)


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Dr. Coleen Murphy is a prominent aging researcher and author of the upcoming book “How We Age: The Science of Longevity” from Princeton University Press. In this wide-ranging discussion, Coleen provides insights into her motivation for writing this book, key topics covered, and her unique perspective on the field. 

Key ideas:

  • Addressing ethical concerns about studying aging and longevity
  • Defining aging conceptually and how metrics like lifespan vs. healthspan are measured
  • Using genetics, transcriptomics and other tools to understand molecular changes in aging
  • The prominent role of reproduction and sex differences in aging
  • Theories on tradeoffs between reproduction and longevity
  • Genetics of aging pathways including insulin/IGF-1, mTOR, and sirtuins
  • Cellular processes involved in aging such as mitochondrial dysfunction, epigenetic changes, senescence
  • The importance of models like C. elegans and Drosophila in aging research
  • Ongoing research and future potential for interventions to increase healthspan
  • The challenge of complex science without excessive jargon
  • Highlighting critical contributions by women scientists in the field
  • Omitting personal lifestyle advice and focusing on evidence-based science
  • The rapid pace of advancement in biotech applications of longevity science

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Translating Aging on Twitter: @bioagepodcast

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