What is information? How does it run the show in biology? In anticipation of a new updated second edition of his classic book The Design Inference, out this month, today’s ID the Future from the vault features Rice University synthetic organic chemist James Tour and intelligent design pioneer William Dembski discussing information theory, information as a meaningful reduction of possibilities, Shannon information versus specified information, and how natural selection has come to function as a God substitute for many scientists, despite the lack of evidence. This is Part 1 of a two-part conversation.