Current COVID-19 vaccines offer great protection from serious illness, but they don't prevent people from becoming infected in the first place. Because of this, researchers have been searching for ways to boost mucosal immunity — the immune response on mucosal surfaces — as this is where the virus is first encountered by the body. Now a team have shown that mucosal immunity can be improved enough to block infection in rhesus macaques by administering booster vaccines directly into their lungs, through inhalation. They hope this could offer a way to stop humans getting COVID-19 in the future.
Research Article: McMahan et al.
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Inhaled vaccine prevents COVID in monkeys

The Nature Podcast brings you the best stories from the world of science each week. We cover everything from astronomy to zoology, highlighting the most exciting research from each issue of the Nature journal. We meet the scientists behind the results and provide in-depth analysis from Nature's journalists and editors. Hosted on Acast. See acast.com/privacy for more information.

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Ever since scientific enquiry began, people have focused mainly on men, or if studies involve animals, on male mice, male rats or whatever it may be. And this has led to gaps in scientists’ understanding of how diseases, and responses to treatment, and many other things might vary between people of different sexes and genders. These days, mainly thanks to big funders like the NIH introducing new guidelines and mandates, a lot more scientists are thinking about sex and, where appropriate, gender. And this has led to a whole host of discoveries.
But all this research is going on within a sociopolitical climate that’s becoming increasingly hostile and polarized, particularly in relation to gender identity. And in some cases, science is being weaponized to push agendas, creating confusion and fear.
It is clear that sex and gender exist beyond a simple binary. This is widely accepted by scientists and it is not something we will be debating in this podcast. But this whole area is full of complexity, and there are many discussions which need to be had around funding, inclusivity or research practices.
To try to lessen fear, and encourage clearer, less divisive thinking, we have asked three contributors to a special series of opinion pieces on sex and gender to come together and thrash out how exactly scientists can fill in years of neglected research – and move forward with exploring the differences between individuals in a way that is responsible, inclusive and beneficial to as many people as possible.
Read the full collection: Sex and gender in science Hosted on Acast. See acast.com/privacy for more information.

Talking about sex and gender doesn't need to be toxic

In this episode:00:46 Using genomics to explain geographic differences in cancer riskThe risk of developing cancer can vary hugely depending on geographic region, but it’s not exactly clear why. To get a better idea, a team has compared the genomes of kidney cancers taken from people around the globe. They reveal a link between geographical locations and specific genetic mutations, suggesting that there are as-yet unknown environmental or chemical exposures in different locations. They hope this work will inform public health efforts to identify and reduce potential causes of cancer.
Research Article: Senkin et al. News and Views: Genomics reveal unknown mutation-promoting agents at global sites
07:46 Research HighlightsResearch reveals that the extinct ‘sabre-toothed salmon’ actually had tusks, and a common fungus that can clean up both heavy-metal and organic pollutants.
Research Highlight: This giant extinct salmon had tusks like a warthog Research Highlight: Garden-variety fungus is an expert at environmental clean-ups
09:55 How disrupting a male mouse’s microbiome affects its offspringDisruption of the gut microbiota has been linked to issues with multiple organs. Now a team show disruption can even affect offspring. Male mice given antibiotics targeting gut microbes showed changes to their testes and sperm, which lead to their offspring having a higher probability of severe growth issues and premature death. Although it’s unknown whether a similar effect would be seen in humans, it suggests that factors other than genetics play a role in intergenerational disease susceptibility.
Research article: Argaw-Denboba et al. News and Views: Dad’s gut microbes matter for pregnancy health and baby’s growth
17:23 Briefing ChatAn updated atlas of the Moon that was a decade in the making, and using AI to design new gene-editing systems.
Nature News: China's Moon atlas is the most detailed ever made Nature News: ‘ChatGPT for CRISPR’ creates new gene-editing tools
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Dad's microbiome can affect offsprings' health — in mice

Many people around the world feel lonely. Chronic loneliness is known to have far-reaching health effects and has been linked to multiple conditions and even early death. But the mechanisms through which feeling alone can lead to poor health is a puzzle. Now, researchers are looking at neurons in the hopes that they may help explain why health issues arise when social needs go unmet.
This is an audio version of our Feature Why loneliness is bad for your health Hosted on Acast. See acast.com/privacy for more information.

Audio long read: Why loneliness is bad for your health

In this episode:
00:46 Optical clocks at seaOptical atomic clocks are the most precise timekeeping devices on the planet, but these devices are huge and difficult to work with, limiting their use outside of the lab. Now, researchers have developed a portable optical clock and demonstrated its robustness by sending it on a perilous sea journey. The team hope that this work will pave the way to more practical uses of optical clocks, such as on satellites where they could help improve the accuracy of GPS technologies.
Research Article: Roslund et al. News and Views: Robust optical clocks promise stable timing in a portable package
09:34 Research HighlightsEvidence of ritual burning of the remains of a Maya royal family, and the first solid detection of an astrophysical tau-neutrino.
Research Highlight: Burnt remains of Maya royalty mark a dramatic power shift Research Highlight: Detectors deep in South Pole ice pin down elusive tau neutrino
11:52 How marsupial gliding membranes evolvedSeveral marsupial species have evolved a membrane called a patagium that allows them to glide gracefully from tree to tree. Experiments show that mutations in areas of DNA around the gene Emx2 were key to the evolution of this ability, which has appeared independently in multiple marsupial species.
Research article: Moreno et al. News and Views: Marsupial genomes reveal how a skin membrane for gliding evolved
19:22 Briefing ChatHow overtraining AIs can help them discover novel solutions, and researchers manage to make one-atom thick sheets of ‘goldene’.
Quanta Magazine: How Do Machines ‘Grok’ Data? Nature news: Meet ‘goldene’: this gilded cousin of graphene is also one atom thick
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Subscribe to Nature Briefing: AI and robotics Hosted on Acast. See acast.com/privacy for more information.

How gliding marsupials got their 'wings'

Humans setting up home in outer space has long been the preserve of science fiction. Now, thanks to advances in technology and the backing of billionaires, this dream could actually be realised. But is it more likely to be a nightmare?
Kelly and Zach Weinersmith join us to discuss their new book A City on Mars and some of the medical, environmental and legal roadblocks that may prevent humanity from ultimately settling in space.
A City on Mars: Can We Settle Space, Should We Settle Space, and Have We Really Thought This Through? Kelly and Zach Weinersmith Particular Books (2023) Hosted on Acast. See acast.com/privacy for more information.

Inhaled vaccine prevents COVID in monkeys

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