Anthony is a 41-year-old male patient who presents for evaluation. His wife made the appointment because she is worried about him, and she says he would never seek care on his own. Reportedly, Anthony has become progressively withdrawn over the last few months, and actually is in danger of losing his job because he misses so many days. He has been evaluated by his primary care provider and has no apparent medical conditions. His wife reports that he has been diagnosed with depression in the past and has even taken medication that seemed to help. This time he just refused to pursue care. After a comprehensive assessment the PMHNP diagnoses the patient with major depressive episode with psychotic features. Which of the following options would be the best choice of initial medication therapy for Anthony?

A. Venlafaxine and clozapine

B. Fluoxetine and olanzapine

C. Amitriptyline and haloperidol

D. Paroxetine and buspirone
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