Inka Land Podcast

Today, my guest is Ryan Smith, a biotech innovator, epigenetics expert, and founder of TruDiagnostic, one of the world’s most advanced labs for biological age testing, DNA methylation analysis, and epigenetic clocks.

He previously founded Tailor Made Compounding, a peptide pharmacy that became fastest-growing healthcare company in the U.S., generating $80 million in revenue in just three years.In this episode, Ryan breaks down the science of anti-aging and longevity peptides, including Tesamorelin, Ipamorelin, SS-31, MOTS-c, Os-01, thymosin alpha-1, and ATX-304—covering how they work, when to use them, and their roles in mitochondrial health, fat loss, muscle growth, immune modulation, and biological rejuvenation.We also discuss FDA regulations around peptides and how peptides compare to pharmaceuticals and lifestyle interventions. We also cover hair growth and skin anti-aging peptides and how to use them.In the second part of the episode, we cover biological age testing (epigenetic age testing), including DunedinPACE, PhenoAge, and telomere length. Finally, Ryan shares his personal peptide protocols for longevity.FREE GUIDEDownload a free supplement guide: https://inkaland.co/supplement-guide------------------------------------------------------

RYAN SMITH & TRUDIAGNOSTICWebsite: trudiagnostic.comLinkedIn: Ryan SmithYouTube: TruDiagnostic ChannelX (formerly Twitter): @TruDiagnostic------------------------------------------------------DISCLAIMERhttps://www.inkaland.co/disclaimer------------------------------------------------------TIMESTAMPSPART 1: ANTI-AGING AND LONGEVITY PEPTIDES00:00 Introduction00:12 Ryan Smith introduction: TruDiagnostic, Tailor Made Peptides03:00 Ryan’s story: Medical school, peptides, and preventive health04:15 What are peptides and how are peptides made?06:50 FDA peptides - are peptides legal?06:50 Peptide vs pharmaceuticals08:50 FDA peptides for anti-aging and prevention10:30 Collagen peptides vs therapeutic peptides12:40 Anti-aging and longevity peptides12:52 SS31: mechanism, mitochondria, and ss-31 uses13:30 Mitochondria peptides, ss-31 continued14:15 Mots-c review17:40 SS31 dosage18:15 Peptides vs small molecules19:20 Anti-aging peptide: Os-01 ATX304 M-kinase, AMPK19:50 AMPK: the longevity anti-aging pathway21:18 ATX304 AMPK-mimetics22:15 ATX304 vs rapamycin vs Berberine vs Metformin24:00 Os-01 vs calorie restriction vs fasting25:50 Peptides vs lifestyle28:40 Peptides for weight loss: Tesamorelin, ipamorelin, cjc 1295, Ozempic, Growth hormone peptides29:20 Growth hormone peptides, igf-131:20 Fat loss peptides: ipamorelin, tesamorelin, glp-1 agonist, ozempic31:20 Peptides for visceral fast32:50 Growth hormone peptides review vs longevity34:18 Glp 1 receptor agonist mechanism of action: Ozempic, semaglutide, etc36:10 Immunity peptides: thymosin alpha 1 benefits37:55 Thymusin beta 4 vs tymosin alpha 138:50 Antimicrobial peptides39:25 Thymusin beta 4 and BPC157 review40:50 sglt2 inhibitors41:40 Peptide protocols: daily use vs cycling42:40 Hair growth peptides43:40 Hair growth peptide: PDT-DBM44:30 Hair growth peptide: GH-CKu copper peptide and thymulin46:50 Copper peptide for face and hair protocol47:35 Ryan Smith peptide protocolPART 2: BIOLOGICAL AGE AND PACE OF AGING48:40 Biological age vs chronological age vs speed of aging51:50 Biological age test: omic age clock, Dunedinpace, Symphony Age52:20 Improving metabolic age, cardiovascular age, and kidney age54:22 Hyberbaric Oxygen: brain health and cardiovascular health54:40 Semaglutide glp 1 receptor agonist and longevity56:30 Dunedinpace test, speed of aging57:58 How does Ryan slow down biological age and speed of aging?59:00 Ryan Smith links, TruDiagnostic

Today, my guest is Dr. Neil Paulvin, DO, a multiple board-certified physician in Family Medicine, Osteopathic Manipulation, and Anti-Aging and Regenerative Medicine. Dr. Paulvin runs a cutting-edge practice in Manhattan, where he combines traditional and alternative medicine to help his patients not only heal—but thrive. His clients include Fortune 500 executives, Olympic athletes, top trainers, and A-list celebrities, all turning to him for faster recovery, peak performance, and total-body optimization.In this episode, we dive into peptides and brain optimization. We first discuss methylene blue and its effects on brain health. We then discuss Methylene blue doses, side effects, and its applications to skin health. We also cover BPC-157 in detail and talk about peptides like MOTS-c and SS-31. We cover cerebrolysin protocols for boosting brain health and cognition. Finally, also discuss other peptides, especially for weight loss, including Tesofensine, amlexanox (AOD), and GLP-1 agonists in general. Dr. Paulvin also shares his clinical experience with red light therapy, exogenous peptides, IV protocols, and how to layer these tools into a hyper-personalized biohacking plan.This episode is a deep dive into safety, dosing, and the real-world results of these compounds.------------------------------------------------------ANNOUNCEMENTSDownload a free supplement guide: https://inkaland.co/supplement-guidehttps://www.inkaland.co/Longevityretreat------------------------------------------------------SUBSCRIBE TOSpotify: https://shorturl.at/wAKM2iTunes: https://podcasts.apple.com/ee/podcast...------------------------------------------------------FOLLOWNewsletter: https://www.inkaland.co/newsletterInstagram:   / iaminkaland  Subscribe:    / @iaminkaland  ------------------------------------------------------DR. JOY KONGWebsite: https://doctorpaulvin.com/YouTube:    / @drneilpaulvin  Instagram: https://www.instagram.com/drpaulvin/?...------------------------------------------------------DISCLAIMERhttps://www.inkaland.co/disclaimer

oday’s guest is Dr. Alexis Ortega, MD, a board-certified regenerative medicine and longevity expert from Barcelona, Spain. He is the founder and medical director of Ad Astra Clinic, specializing in advanced regenerative strategies and skin, hair, and longevity treatments. With multiple degrees in regenerative medicine, aesthetic medicine, stem cell therapy, and longevity, Dr. Ortega brings a wealth of knowledge and detail to regenerative medicine.

Today, my guest is Dr. Joy Kong, MD, a triple-board-certified global expert in stem cell therapy and regenerative medicine, researcher, and author. She is the CEO of Uplyft (Charahealth) Longevity Center and Charahealth stem cell skin care.

In this episode, I'm honored to interview Professor Thomas Seyfried, a renowned expert in cancer research. He is a professor of biology, genetics, and biochemistry at Boston College. Prior to this, he was an assistant professor of neurology at Yale. He has published over 150 peer-reviewed scientific articles and has been awarded by multiple prestigious organizations, including the NIH. He serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro. Dr. Seyfried is the author of “Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley Press).”

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Today, my guest is Dr. Matt Kaeberlein, a CEO of Optispan, anti-aging researcher, Professor at the University of Washington, and founding Director of the University of Washington Healthy Aging and Longevity Research Institute. Dr Kaeberlein is the author of over 250 published scientific research articles on aging, healthspan, and longevity of people and companion animals. Dr. Kaeberlein is a Fellow of the American Association for the Advancement of Science, the American Aging Association, and the Gerontological Society of America. He has received numerous prestigious awards from organizations such as the Alzheimer’s Association and the National Institutes of Health. He has co-founded two companies, Ora Biomedical, Inc., a leading longevity drug discovery biotech, and Optispan, Inc., a healthcare technology company focused on developing innovative tools for 21st-century medicine. He is also the Co-Founder of the Dog Aging Project and Dog Aging Institute.

In this episode, my guest is Cynthia Thurlow, a nurse practitioner and the author of the best-selling book Intermittent Fasting Transformation. Her TEDx talk on Intermittent Fasting currently has over 14 million views. With over 20 years of experience in health and wellness, Cynthia is a globally recognized expert in intermittent fasting and women’s health. Her mission is to educate women on the benefits of intermittent fasting and overall holistic health and wellness and help all women live their most optimal lives.

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Watch on YouTube: https://www.youtube.com/watch?v=htmbcH1ux_s

Dr. Elena Seranova:

https://youtu.be/AUqNF8YCxHE?feature=shared

In this episode, my guest is Dr. James DiNicolantonio, who holds a Doctor of Pharmacy degree and is a distinguished cardiovascular research scientist. His research contributions include coauthoring more than 300 peer-reviewed scientific articles, demonstrating his extensive influence in the field of medicine. Dr. DiNicolantonio serves as an associate editor for the British Medical Journal's Open Heart and is a valued member of the editorial advisory boards for various prestigious medical journals. In addition to his contributions to scientific literature, he has authored nine best-selling health books, including "The Salt Fix," "Superfuel," "The Longevity Solution," "The Immunity Fix," "The Mineral Fix," "WIN," "The Obesity Fix," "The Collagen Cure," and "The Blood Sugar Fix." Over 2.5 million people follow his health and science insights on Instagram.