In this episode, Drs Trexler and Helms discuss various topics including updates on Eric's surgery, the valuable (but very modest) effects of protein intake on muscle gains, incontinence after contest prep,  the relationship between sleep quality and nutrient timing, the recent ban on smelling salts in the NFL, and more.

Time stamps: 00:00 Introduction 01:11  Preview of next week's episode (non-responders, hyper-responders, etc) 07:01 Trex's surgery update 12:11 Discussion on Protein Meta-Analyses and Research Updates (how much does protein intake actually matter for gains?) 33:10 Why meta-analyses differ from RCTs in terms of "expiration dates" 44:15 The Impact of Training vs. Nutrition (for muscle growth) 51:41 Q&A: Supplementation for Lifters (and Specifically Vegans Who Lift) 55:49 Incontinence, Increased Urine Output, and Contest Prep 59:16 Chrono Nutrition and Sleep Quality 01:11:28 The Role of Smelling Salts in Sports Performance (and Football)

In this episode of Iron Culture, Helms and Trex have a lengthy discussion about the ECA stack and yohimbine. The history, the mechanisms, the regulatory changes, the practical applications – you name it, they cover it. Don’t miss this episode if you have an interest in fat loss, stimulants, or dietary supplementation in general.

Also, be sure to check out the newest issue of the MASS Research Review! Learn more at massresearchreview.com

Time stamps 0:00 Intro 4:18 New issue of the MASS Research Review 10:42 Helms contest prep update 13:15 The history of the ECA stack and supplement regulation 30:07 Ephedra vs Ephedrine  35:31 Why people took ephedrine / ECA stack 36:30 Trends in PED use over time 45:00 Research on the ECA stack 50:58 Banning lifters for stimulant use 53:15 Effects of ephedrine + caffeine on metabolism and fat loss 1:02:44 What does aspirin really add to the ECA stack? 1:13:00 Do NSAIDs blunt hypertrophy? 1:21:25 How yohimbine works (and yohimbe vs yohimbine distinction) 1:31:10 Regulatory status of yohimbine 1:32:58 Practical applications

Back when Trex was a 14 year old, his wrestling coach noticed his passion for training and nutrition. This coach took Trex under his wing, and they started absorbing and applying as much information as they could. Their source material, almost exclusively, was the content produced by Dr. Jim Stoppani – primarily from magazine articles, but also from the totally novel medium of online video content. Jim was a jacked PhD with tons of “in the trenches” experience - back in 2005 that was a very rare combination, and there’s no question that people like Jim led the way for the next generation of “bodybuilding academics” like Helms and Trex.

Jim has made a huge mark on the fitness industry. Perhaps his most impressive feat is maintaining his impact and relevance as the industry has fundamentally transformed itself multiple times. Jim was the face of some of the biggest muscle magazines (in their prime), one of the most recognizable content creators when bodybuilding dot com was THE place for online fitness, and way ahead of the curve when it comes to building your own platform and leveraging mobile fitness applications. In this episode of Iron Culture, the Erics have a great chat with Dr. Stoppani about how the industry (and science communication more broadly) has evolved over the last 25-30 years.

To learn more about Jim and support his work, check out his social media channels and his website

https://www.jimstoppani.com/

Time stamps

0:00 Intro

3:22 Jim’s education

14:18 Jim’s transition to the muscle magazine industry

30:44 Jim’s bodybuilding dot com days

44:52 Fitness content creation in the age of social media: the good, the bad, and the ugly

Join hosts Eric Trexler and Eric Helms as they explore the potential "replication crisis" in exercise science, drawing parallels to the well-documented crisis in psychology. In this episode, they delve into the challenges of replicating research findings, the perils of placing too much confidence in singular studies, the importance of cautious interpretation of new studies, and the value of meta-analyses in understanding true effect sizes. Whether you're a seasoned lifter or new to the world of evidence-based practice, this conversation offers valuable insights into making informed decisions about your training.

Time stamps: 00:00 – Introduction (and Helms’ travel updates) 17:29 - Replication Crisis in Psychology: Discussion on the replication crisis observed in psychology and its implications. 32:45 – What is “replication” 44:36 – Results of “reproducibility project” in exercise science 1:00:04 – Why are replication rates so low in exercise science? 1:27:24 – What does this mean for “evidence-based fitness” and application of exercise science?

Relevant links: www.massresearchreview.com https://pubmed.ncbi.nlm.nih.gov/26315443/ https://pubmed.ncbi.nlm.nih.gov/40522610/

In this episode of Iron Culture, Dr. Eric Trexler and Dr. Lauren Colenso-Semple discuss science related to attractiveness, coolness, and personality type. They explore scientific studies on the factors associated with perceived attractiveness and "coolness," discussing body fat percentages and societal perceptions. The conversation shifts to how personality traits appear to predict workout preferences and engagement in fitness, then they debate the importance of matching exercise to individual characteristics.

Time stamps: 00:00 Introduction to Iron Culture and Guests 5:57 The Science of (Male) Attractiveness 10:39 Evolutionary Underpinnings of Male Attractiveness 13:53 Distorted Perceptions of Attractiveness (In the Fitness World) 20:10 The Irony of Pursuing Attractiveness 22:22 Body-Fat and Optimized Health 24:18 Surprising Article Feedback 28:50 Unrealistic Body Standards and Gender Perceptions 32:49 Achieving the Outcome Versus Doing Hard Things 35:07 Attractiveness is More Than Body Shape/Size 37:48 The Science of Being Cool 47:19 Matching Exercise To Personality Types

References:

Xia F, Sauciuvenaite J, Bissland R, Hambly C, Starr-Vaanholt L, Faries MD, et al. The relationship between body fatness and physical attractiveness in males. Personality and Individual Differences. 2025 Sep 1;243:113240.

de Jager S, Coetzee N, Coetzee V. Facial Adiposity, Attractiveness, and Health: A Review. Front Psychol. 2018 Dec 21;9:2562.

Brierley ME, Brooks KR, Mond J, Stevenson RJ, Stephen ID. The Body and the Beautiful: Health, Attractiveness and Body Composition in Men’s and Women’s Bodies. PLoS One. 2016;11(6):e0156722.

Sorokowski P, Kościński K, Sorokowska A, Huanca T. Preference for Women’s Body Mass and Waist-to-Hip Ratio in Tsimane’ Men of the Bolivian Amazon: Biological and Cultural Determinants. PLoS One. 2014 Aug 22;9(8):e105468.

Tovée MJ, Cornelissen PL. Female and male perceptions of female physical attractiveness in front-view and profile. Br J Psychol. 2001 May;92(Pt 2):391–402.

Jayedi A, Khan TA, Aune D, Emadi A, Shab-Bidar S. Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Int J Obes (Lond). 2022 Sep;46(9):1573–81.

Hu J, Chen X, Yang J, Giovannucci E, Lee DH, Luo W, et al. Association between fat mass and mortality: analysis of Mendelian randomization and lifestyle modification. Metabolism. 2022 Nov;136:155307.

Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sørensen TIA, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod. 2007 Jun;22(6):1634–7.

Wei S, Schmidt MD, Dwyer T, Norman RJ, Venn AJ. Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin. Obesity (Silver Spring). 2009 May;17(5):1070–6.

Liu Y, Hu X, Xiong M, Li J, Jiang X, Wan Y, et al. Association of BMI with erectile dysfunction: A cross-sectional study of men from an andrology clinic. Front Endocrinol (Lausanne). 2023;14:1135024.

https://psycnet.apa.org/doiLanding?doi=10.1037%2Fxge0001799

https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1587472/full

In this episode of Iron Culture, Eric Helms interviews Dr. Stian Larsen, who shares his journey from powerlifting to becoming a researcher in exercise science. They discuss the intricacies of biomechanics, the importance of understanding squat techniques, and the latest research findings on muscle hypertrophy and resistance profiles. Stian emphasizes the need for practical applications in training and the significance of collaboration in research. The conversation also touches on future research directions and the role of education in advancing the field of strength training.

Time stamps 0:00 Introduction 4:33 Stian's Journey in Powerlifting and Coaching 16:00  Biomechanics and the Sticking Point in Squats  23:56 Understanding Muscle Forces and Training Strategies 33:04 Transitioning to Hypertrophy Research 35:43 Research on Muscle Length and Hypertrophy 48:58 Practical Applications of Research Findings 50:02 Biceps Research Findings and Surprises 1:03:28 Practical Applications of Research Findings 1:04:53 Quadriceps Hypertrophy Study Results 1:22:27 Lateral Raises and Resistance Profiles

In this episode of Iron Culture, the Erics provide some updates, corrections, and clarifications related to their recent episode exploring the science of microplastics. After that they take a brief moment to celebrate the 100th issue of the MASS Research Review, then answer listener questions on topics including: tasty meat alternatives, programming supersets, scaling dietary variables for very small/short individuals, the pros & cons of "extended release" caffeine formulations, the utility & shortcomings of BMI as a health metric, and more.

MASS is celebrating its 100th issue, but it's never to late to join in on the fun! Learn more at massresearchreview.com

Also, don't miss Iron Culture's sister podcast,  ⁨@fpfpodcast⁩  hosted by MASS's very own Eric Trexler and Dr. Lauren Colenso-Semple

Time stamps (coming soon): 0:00 Intro 0:58 Revisiting microplastics (updates, corrections, and clarifications) 25:08 MASS celebrates 100th issue 34:00 Well-wishes for bodybuilding legend Ronnie Coleman 41:37 Tasty meat alternatives 47:12 Programming supersets 49:23 Scaling dietary variables for very small/short individuals 57:10 The utility & shortcomings of BMI as a health metric 1:05:03 Individual response variation to training 1:16:12 The pros & cons of "extended release" caffeine formulations

In this episode of Iron Culture, Dr. Eric Helms talks about his forthcoming article in the MASS Research Review covering the purported harms of high-protein diets. This isn’t your typical oversimplified dunk-fest that readily dismisses concerns about high-protein diets. Instead, Helms reviews a thorough paper that reviews common concerns in detail and assessed their plausibility in an objective manner. The claims include: 

Claim 1 – protein reduces lifespan Claim 2 – protein makes bones weaker Claim 3 – protein harms kidneys Claim 4 – protein causes diabetes

After that, Dr. Eric Trexler discusses a recent Instagram thread that pulled him into arguments against his will. The post was about his recent article on ketogenic diets and seed oils – two topics that are always bound to attract some controversy and heated debate. This conversation discusses the strengths and limitations of different types of scientific research and also touches on bias, objectivity, and the process of seeking the truth with an open mind.

Time stamps: 0:00 Intro 3:00 Helms’ new article about the purported harms of high-protein diets 19:25 Claim 1 – protein reduces lifespan 27:48 Claim 2 – protein makes bones weaker 43:38 Claim 3 – protein harms kidneys 50:53 Claim 4 – protein causes diabetes 57:22 Trex’s social media beefs – keto and seed oils 1:03:40 Types of observational studies 1:08:35 Seeking truth versus defending biases 1:17:32 Limitations versus fatal flaws 1:24:19 Limitations of RCTs (randomized controlled trials) 1:32:23 Wrapping up

In this episode, the hosts discuss various aspects of bodybuilding prep, including caloric intake, metabolic adaptation, and the impact of extreme dieting. They explore historical studies that provide insights into these phenomena and discuss practical strategies for weight loss. The conversation transitions to powerlifting, specifically the recent IPF Worlds, highlighting the competitive dynamics and standout performances in the event. In this conversation, Eric Helms highlights impressive performances and battles in various weight classes. He emphasizes the growth of the sport and the challenges faced by lifters, particularly in extreme conditions. The subsequent Q&A covers the balance between powerlifting and bodybuilding, exercise order for hypertrophy, and the relationship between energy balance and recovery. Additionally, the practicality and effectiveness of using weighted vests for exercise are examined, providing insights into their potential benefits and drawbacks.

Time stamps:

00:00 Introduction and Helms' Updates on Bodybuilding Prep

01:50 Caloric Intake and Metabolic Adaptation

05:35 Extreme Cases of Metabolic Adaptation: Insights from Historical Studies

25:26 IPF Worlds Recap

44:44 Programming for Powerlifting and Bodybuilding (Simultaneously)

48:26 Exercise Order and Hypertrophy

01:00:23 Energy Balance and Recovery

01:05:44 The Pros and Cons of Weighted Vests

In this episode of Iron Culture, the Erics begin by discussing Helms' prep updates and the standout performances from the recent powerlifting World Champions. The conversation also touches on body composition and attractiveness, highlighting the misconceptions in the fitness industry regarding ideal body fat levels. After that they take a deep dive into the strategies of cutting weight in various sports, comparing the approaches of powerlifting, bodybuilding, and combat sports. Finally, they explore the differences in weight cutting techniques across different sports, emphasizing the importance of planning and strategy for optimal performance.

Time stamps: 00:00 Helms Prep Update and World Powerlifting Highlights 15:07 Body Composition, Attractiveness, Evolution, and the Fitness Industry 31:16 Trexler's Take On Comparing Weight Cuts in Different Sports (Powerlifting, Bodybuilding, Combat Sports) 40:32 Helms' Take On Comparing Weight Cuts in Different Sports (Powerlifting, Bodybuilding, Combat Sports) 57:11 Electrolyte Management and Hydration Techniques 1:03:05 Final Thoughts on Weight Management and Performance