Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and today lets hit half a century with a brand new barrier to drug distribution namely the Placental barrier where we will discuss the passage of drugs across placenta. Firstly, I will tell you about the lipoidal nature of membranes and then accordingly I will list the drugs that pass or are restricted through it. Next, I will give an account of efflux transporters like P-gp, BCRP and MRP3, then I will be describing some influx transporters, their effect on drug passage, then next we will talk about importance of "ion trapping" with reference to context of placenta, and finally we will conclude the fact of Placenta being an incomplete barrier and hence no drug should be given to the pregnant mother, not even before delivery!! With these interesting, small, quick, crisp facts, we will wind up today's session. Till next episode, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode we are going to plan an online meeting via youtube live and zoom app. The details are as follows:

Passcode: 6jqi32

Time: Aug 7, 2020 03:00 PM Mumbai, Kolkata, New Delhi

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, and in today's episode, I will be finishing the topic of Blood Brain Barrier with few modifications, differences, exceptions and whole lot of information and knowledge to share! First of all I will be telling you about the independence of drug exit from CSF from lipid solubility, next a word about Enzymatic barrier , its relation to the prior example of xenobiotics in last sessions, then a modification of blood bran barrier will be told under the head of Blood-CSF and CSF-Brain barrier. This makes today's episode unique, interesting and full of new flock of knowledge , hope you all enjoy it, another announcement is regarding my creation of SUBSCRIBER'S PAGE on my website, till next episode, do subscribe on my website, follow me here, stay tuned like always, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode, I certainly have brought a bunch of new fresh roses to share for you all, to arrange in the emptiness of your curious, anxious, knowledge thirsty vase of mind and thoughts, Hope it sounds as fresh as ever and is as beautiful as you expect it to satiate your hearing senses. I begin today's session with yesterday's derivation of a novel concept about as to which drugs can and which cannot pass through Blood Brain Barrier owing to their chemical structure and nature, Then I will tell you that it doesn't end here as to apart from chemical behaviour certain disease states also change the permeability of BBB. Then diving deep in this concept, I will tell you about very important five leaky or permeable regions of brain, the reason being occluding zonulae, and much much more.....I advise you to stay tuned, do follow me here, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, and. in today's episode, we will be knowing about the morphological picture of Blood brain Barrier abbreviated as BBB. I will let you know how its is anatomically in true terms a "dual barrier", the first one being blood brain barrier and second one being the blood - CSF barrier. Next as we continue with our "open sesame" magical words, I will tell you some wonderful facts about efflux transporters located along BBB , their examples and how they function. You will be learning some new terms like "Xenobiotics", their weird and strange examples and their clinical worth! With this information, I will put a halt to my tongue twists, hope you all liked it, till next episode, do follow me here, stay tuned, your appreciation on google review is a welcome response, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode listen to my pizza making story to mark the beginning of a new topic and it is the Introduction to Distribution of Drugs, and you would be amazed as to how I relate the sprinkling of my mixed herbs on pizza to the drug distribution process! Then I will give the definition of Drug disposition which deals with distribution, metabolism and excretion of drugs. It is an important part of pharmacokinetics. One more fact is added to your sea of knowledge that the division of body compartments in which the drug is distributed is actually physiological and not anatomical. This fact will be depicted by giving you a virtual flowchart to soothe your scientific ears. Hope you all like it, till next session, do follow me here, stay tuned, and I expect a five star google review from all of you too, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's session let us talk about the last two pharmacological factors affecting Drug Absorption and Bioavailability. The first amongst these is pharmacogenetic factors , I will be repeating and revising the definition and with one old example, I will add on a scoop of new one too , serving you a new flavour of this topic. Secondly we will be conversing about some of miscellaneous factors like route of drug administration, area of absorbing surface and state of circulation. Yes, these are clubbed in our last factor but have individual importance of great value, never forget that! And lo, we put a fullstop to this topic which we are doing from last three days!! Tomorrow's topic will be brand new, till then, do follow me here, stay tuned, do give a great review on google, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast, I am Dr Radhika Vijay, and today we will be talking about few more pharmacological factors affecting drug absorption and bioavailability starting off today's episode with food and various substances, this particular description is full of versatile and exceptional examples to account for! Next turn is of First pass metabolism, hope you remember about this one factor and I need not exaggerate it more except some great examples which i serve in your plate to chew hard and store in your brains forever! Last one for today is a riddle in itself, first I give you all examples then we guess the heading, I am sure you will love this brainstorming exercise! Before waiving you and this month of July 2020 a good gracious night, please follow me here, stay tuned, give me a great review on google reviews and i will be very very thankful!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! Today's podcast recording was in a mood observing the changing times around all of us, changing season, weather, August is dawning, and Taylor's song august on repeat, Well our topic has changed too!! Its the pharmacological factors affecting drug absorption and bioavailability. To start the discussion, comes the first. factor which is gastrointestinal motility along with gastric emptying. whole description goes hand in hand with examples, so no worries dear all! Second to state is actually a pathophysiological factor called gastrointestinal diseases and truly you'll be wondering in amazement once you hear this one! So, Is Pharmacology Difficult, do answer and convey to me your reviews here----https://www.google.com/maps/place/Is+pharmacology+difficult/@28.0104311,73.3316503,15z/data=!4m2!3m1!1s0x0:0xca903a4343b5483a?sa=X&ved=2ahUKEwivxfDmk_XqAhVs6XMBHbivAYsQ_BIwFXoECBEQCA

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, today continuing with the yesterday's conversation about pharmaceutical factors affecting drug absorption and bioavailability, we will be heading over directly to the next and third factor which is Crystal form of drug, this is followed by water of hydration leading to formation of hydrous forms of drugs! Next talk is about nature of excipients and adjuvants and finally we will be winding our today's talk show with degree of ionisation description. All factors are explained with suitable beautiful examples , hence you will be left with a picture in your mind enlisting all the factors one by one without hurdle! Isn't that a boon of knowledge, for more such crispy audio files, do stay tuned, follow me here, thank you!!