Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode I will be collecting messages from sea shells as we together walk through the shores of knowledge, First shell tells us that passage of drug across the membranes and capillary walls depends on lipid solubility which in turn determines the volume of distribution. Second pearl of knowledge states that high or low plasma protein binding determines the volume of distribution and also determines where a drug stays or is restricted to. Next pearl conveys the message that volume of distribution decides whether or not poisoning state of drug in case if occurs would be benefitted by heamodialysis or not , indirectly telling the basis of heamodialysis. Last pearl is highly scintillating with a spark of diamond, it whispers in ears that numerical value of volume of distribution may be variable and accordingly holds different significance and also tells that diseases like CHF, Ureamia and cirrhosis also affect volume of distribution by different mechanisms. All in all, 4 pearls stand for 4 smiles of the day, stay enlightened, do follow me here, stay tuned, thank you!!

Welcome to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode, I will be introducing the Apparent Volume of Distribution , no more a teaser, today is narrated the introduction finally. Building up a story background for the real concept, I have explained an example of Digoxin, which eventually leads us to the word "APPARENT" and then to volume of distribution, which is actually apparent concept, then going deeper, I will be deriving a proper equation for mathematical calculation of apparent volume of distribution, then I will let you know its unit which is L/kg which you need to remember and finally with a word as to how we can make different generalisations or use this as a pharmacokinetic tool, I will be giving a halt to my talk today. Trending today is my WEEKEND CLASSROOM, which will be updated every Sunday on my YouTube channel, do attend it for a quick weekly summary of topics, hope you like this new endeavour, till next session, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, wrapped up in spirit of freedom and independence, with all respect, gratitude for our freedom fighters, I will be talking about the final important clinical aspect of plasma protein binding as to how and why the disease, conditions of physiological stress and pathological states affect the plasma protein binding upto a level significant clinically. In this I will talk about the conditions renal failure, liver disease leading to hypoalbuminemia and then with examples I will be furnishing the details appropriately. Then with a word about the fact that its both the bound and free form form of drug referred to amount in vitro, while referring to especially the MIC of antimicrobial, I will be expressing my love for MOTHER INDIA in my native HINDI language in form of a poetry, hope you all like it, do follow me here, stay tuned, JAI HIND!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, in today's episode our plane will take off with full zest and fun and land in beautiful ground of Plasma protein binding where we will take our steps further ahead..I will be commencing today's episode with the fact that drug binds to multiple sites on albumin and multiple drugs bind to same site(s). All this leads to a lot of displacement drug interactions of which final outcome depends on grade of affinity of the drug, then there are many things to talk about as to the gravity of the situation, as to should we really worry or not worry about these displacement drug interactions, With a lot of examples, and proper, firm basis I will be evaluating or measuring the depth of seriousness of this whole concept and will be sharing all information through and through so that there are no rooms of over emphasis or exaggerations of the whole picture, no over painting, just the true colors all in all you will see, hope you all like it, till net episode, do rate and review, follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, still standing firm, not hanging on the staircase of Plasma protein Binding. Today's celebrated title goes like the Important Clinical Aspects of Plasma Protein Binding. As we head on in this direction point by point, we start with the fact that highly protein bound drugs are restricted to vascular compartment, having lower volumes of distribution. I will be giving a tabular format of highly bound drugs to albumin as well as alpha 1 acid glycoprotein. Second statement informs us about the importance of bound fraction of drug, how plasma protein binding acts as storage room! Last fact of the day states that plasma protein binding makes the drug damn long acting!! Brushing this  knowledge with more scientific sentences, I will give you a break before your brains are stormed with winds of plasma protein binding..till next episode, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and today lets climb a step more the ladder of Plasma protein binding, yesterday the step took us to the room of Albumin, and today's the turn of alpha1- acid glycoprotein . In this room, we will find other proteins too like tissue proteins, nucleoproteins, and lastly miscellaneous proteins like transcortin, gamma globulins and alpha globulins. You studious listeners should not be amazed by so many plasma proteins, rather their so many examples really turns on the excitement and curiosity into the depths of subject more and more! So, keep on gliding along the waves of literature, have great fun learning , cos' Never forget, "Every day is a new chapter of life!!" With this great thought, let us put a full stop to today's conversation, With a promise to see you all tomorrow, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, In today's episode I will take a step ahead in stairs of plasma protein binding and give you more jewels of information, Firstly we will get to learn about basic concepts that acidic drugs bind mainly to Albumin, then next step is to know about Albumin as to its molecular net charge, then how it binds basic drugs so much in amount and then readily release them, making it high capacity and low affinity, while its totally opposite for acidic drugs that it has only two binding sites for acidic drugs but the binding is very strong making it low capacity but high affinity, so thats quite interesting and surprising fact! Then I will be sharing some quick data about drugs like benzodiazepines binding percentage just to support the fact that saturation of plasma proteins is unlikely to the doses of drugs taken by an individual, well! Thats too surprising but yet true!! Hope you all like this crisp, informative audio piece, till next episode , do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! As I promised yesterday, I am here with a brand new type of barrier and the topic goes as Plasma Protein Binding. Today is simply the Introduction to this important, extensive and must to be understood topic. Firstly comes the background description which explains that drug partly exists in free form and partly in bound form! But these two forms always exist in dynamic equilibrium and in a sort of reversible equation given as:

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! In today's episode we will be do a short communication about few more special compartments for drug distribution , say like bones, teeth, fat acting as reservoirs of drug accumulation. Then there are also some transcellular reservoirs like pleural, pericardial , peritoneal sacs, CSF, endolymph, aqueous humor, etc. All are described so as to form a clear picture in your mind frames, all come in a package full of examples which will make you wonder more as some of the descriptions are so so amazing as to satisfy your curiosity and wish to know more and new!! "NEW IS ALWAYS IN VOGUE, and today's topic stands the test of time, so go ahead, listen and dive deep in this ocean of new waters to explore, hope you all like it, till next episode, do follow me here, stay tuned, thank you !!

Welcome to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, In today's episode we will talk about some special compartments of drug distribution which are also known as "Sanctuary Compartments". Heading on this way, our first stop of a classical example is the Cellular reservoir of drugs where I will tell you about a tabular form of learning various tissues of body and their respective particular drug which have higher affinity for these tissues. The interesting fact is that these drugs only accumulate here and exert no pharmacological effect! A piece of advice is to quickly go through the long list of tissues and drug accumulated as examples once again, till the next episode, do follow me here, stay tuned, thank you!!