Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, still standing firm, not hanging on the staircase of Plasma protein Binding. Today's celebrated title goes like the Important Clinical Aspects of Plasma Protein Binding. As we head on in this direction point by point, we start with the fact that highly protein bound drugs are restricted to vascular compartment, having lower volumes of distribution. I will be giving a tabular format of highly bound drugs to albumin as well as alpha 1 acid glycoprotein. Second statement informs us about the importance of bound fraction of drug, how plasma protein binding acts as storage room! Last fact of the day states that plasma protein binding makes the drug damn long acting!! Brushing this  knowledge with more scientific sentences, I will give you a break before your brains are stormed with winds of plasma protein binding..till next episode, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and today lets climb a step more the ladder of Plasma protein binding, yesterday the step took us to the room of Albumin, and today's the turn of alpha1- acid glycoprotein . In this room, we will find other proteins too like tissue proteins, nucleoproteins, and lastly miscellaneous proteins like transcortin, gamma globulins and alpha globulins. You studious listeners should not be amazed by so many plasma proteins, rather their so many examples really turns on the excitement and curiosity into the depths of subject more and more! So, keep on gliding along the waves of literature, have great fun learning , cos' Never forget, "Every day is a new chapter of life!!" With this great thought, let us put a full stop to today's conversation, With a promise to see you all tomorrow, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, In today's episode I will take a step ahead in stairs of plasma protein binding and give you more jewels of information, Firstly we will get to learn about basic concepts that acidic drugs bind mainly to Albumin, then next step is to know about Albumin as to its molecular net charge, then how it binds basic drugs so much in amount and then readily release them, making it high capacity and low affinity, while its totally opposite for acidic drugs that it has only two binding sites for acidic drugs but the binding is very strong making it low capacity but high affinity, so thats quite interesting and surprising fact! Then I will be sharing some quick data about drugs like benzodiazepines binding percentage just to support the fact that saturation of plasma proteins is unlikely to the doses of drugs taken by an individual, well! Thats too surprising but yet true!! Hope you all like this crisp, informative audio piece, till next episode , do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! As I promised yesterday, I am here with a brand new type of barrier and the topic goes as Plasma Protein Binding. Today is simply the Introduction to this important, extensive and must to be understood topic. Firstly comes the background description which explains that drug partly exists in free form and partly in bound form! But these two forms always exist in dynamic equilibrium and in a sort of reversible equation given as:

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! In today's episode we will be do a short communication about few more special compartments for drug distribution , say like bones, teeth, fat acting as reservoirs of drug accumulation. Then there are also some transcellular reservoirs like pleural, pericardial , peritoneal sacs, CSF, endolymph, aqueous humor, etc. All are described so as to form a clear picture in your mind frames, all come in a package full of examples which will make you wonder more as some of the descriptions are so so amazing as to satisfy your curiosity and wish to know more and new!! "NEW IS ALWAYS IN VOGUE, and today's topic stands the test of time, so go ahead, listen and dive deep in this ocean of new waters to explore, hope you all like it, till next episode, do follow me here, stay tuned, thank you !!

Welcome to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, In today's episode we will talk about some special compartments of drug distribution which are also known as "Sanctuary Compartments". Heading on this way, our first stop of a classical example is the Cellular reservoir of drugs where I will tell you about a tabular form of learning various tissues of body and their respective particular drug which have higher affinity for these tissues. The interesting fact is that these drugs only accumulate here and exert no pharmacological effect! A piece of advice is to quickly go through the long list of tissues and drug accumulated as examples once again, till the next episode, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and today lets hit half a century with a brand new barrier to drug distribution namely the Placental barrier where we will discuss the passage of drugs across placenta. Firstly, I will tell you about the lipoidal nature of membranes and then accordingly I will list the drugs that pass or are restricted through it. Next, I will give an account of efflux transporters like P-gp, BCRP and MRP3, then I will be describing some influx transporters, their effect on drug passage, then next we will talk about importance of "ion trapping" with reference to context of placenta, and finally we will conclude the fact of Placenta being an incomplete barrier and hence no drug should be given to the pregnant mother, not even before delivery!! With these interesting, small, quick, crisp facts, we will wind up today's session. Till next episode, do follow me here, stay tuned, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode we are going to plan an online meeting via youtube live and zoom app. The details are as follows:

Passcode: 6jqi32

Time: Aug 7, 2020 03:00 PM Mumbai, Kolkata, New Delhi

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay, and in today's episode, I will be finishing the topic of Blood Brain Barrier with few modifications, differences, exceptions and whole lot of information and knowledge to share! First of all I will be telling you about the independence of drug exit from CSF from lipid solubility, next a word about Enzymatic barrier , its relation to the prior example of xenobiotics in last sessions, then a modification of blood bran barrier will be told under the head of Blood-CSF and CSF-Brain barrier. This makes today's episode unique, interesting and full of new flock of knowledge , hope you all enjoy it, another announcement is regarding my creation of SUBSCRIBER'S PAGE on my website, till next episode, do subscribe on my website, follow me here, stay tuned like always, thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay and in today's episode, I certainly have brought a bunch of new fresh roses to share for you all, to arrange in the emptiness of your curious, anxious, knowledge thirsty vase of mind and thoughts, Hope it sounds as fresh as ever and is as beautiful as you expect it to satiate your hearing senses. I begin today's session with yesterday's derivation of a novel concept about as to which drugs can and which cannot pass through Blood Brain Barrier owing to their chemical structure and nature, Then I will tell you that it doesn't end here as to apart from chemical behaviour certain disease states also change the permeability of BBB. Then diving deep in this concept, I will tell you about very important five leaky or permeable regions of brain, the reason being occluding zonulae, and much much more.....I advise you to stay tuned, do follow me here, thank you!!