Centrifugal microfluidics has experienced much growth in recent years, especially in applications such as lab-on-a-disc (LoD) diagnostics. The strength of LoD systems lies in their potential for development into integrated sample-to-answer analysis systems. Author Ling X. Kong talks about her review of technologies necessary to develop next gen systems, valving and other fluid-handling operations, and the future of LoD reagent storage, sample prep, nucleic acid amplification, and analyte detection strategies.