Maria Mori Brooks, PhD, University of Pittsburgh School of Public Health, discusses "Assessing Unexpected Circumstances That Lead to Modifications in Clinical Trial Design, Conduct, or Analysis" in the JAMA Guide to Statistics and Methods series, with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Assessing Unexpected Circumstances That Lead to Modifications in Clinical Trial Design, Conduct, or Analysis

Lars W. Andersen, MD, MPH, PhD, DMSc, Aarhus University, discusses collider bias in the JAMA Guide to Statistics and Methods series with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Collider Bias

John M. Lachin, ScD, Biostatistics Center, George Washington University, discusses Nonparametric Statistical Analysis with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Nonparametric Statistical Analysis

Andrew D. Althouse, PhD, University of Pittsburgh School of Medicine discusses The Use of Historical Controls in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• The Use of Historical Controls in Clinical Trials

Barbara Wendelberger, PhD, Berry Consultants, discusses Futility in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Futility in Clinical Trials

William J. Meurer, MD, MS, University of Michigan Medical School, discusses Interim Analyses During Group Sequential Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Interim Analyses During Group Sequential Clinical Trials

Jerome I. Rotter, MD, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Department of Pediatrics, Harbor-UCLA Medical Center, discusses Genome-Wide Association Studies with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Genome-Wide Association Studies

Benjamin R. Saville, PhD, president and lead statistical scientist of Adaptix Trials, LLC and adjoint associate professor of biostatistics at Vanderbilt University Medical Center, discusses Conditional Power: How Likely Is Trial Success? with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Conditional Power

Anna E. McGlothlin, PhD, Berry Consultants, LLC, discusses Bayesian Hierarchical Models with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Bayesian Hierarchical Models

Kelley Kidwell, PhD, professor of biostatistics, University of Michigan, discusses Sequential, Multiple Assignment, Randomized Trial Designs with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content:

• Sequential, Multiple Assignment, Randomized Trial Designs