A veteran of the Reagan and George H.W. Bush administrations, John Walters was “Drug Czar” of the George W. Bush administration (director of the White House Office of National Drug Policy from 2001-2009). In this Conversation, Walters discusses the opioid epidemic and the country's shocking passivity about addressing the crisis seriously and comprehensively. Reflecting on the devastating consequences of the opioid threat, Walters makes a compelling case for fighting back—through urgent changes to the way we approach law enforcement, combatting foreign sources of supply, education about drug abuse, and treatment for addiction.