JournalSpotting

Looking for the right gateway drug to help start up an insatiable medical literature habit? 

JournalJunkies, your ears are in the right place!

Today we interview Dr James Galloway, rheumatologist, semi- ornithologist, clinical lecturer, and head of the TACTIC trial at King's Hospital.
He helps guide us through the mysteries of immunomodulation in COVID in understandable terms. What do the trials show us? Why? And, what is on the COVID horizon?

02:00    Introductions
02:45    Why the birds aren't coming to your garden
04:45    The Recovery Trial
08:00   Why Steroids?
09:35    REMAP CAP
13:45    The conflicting Tocilizumab data
17: 40    What is Tocilizumab and why might it work?
24:50     The value of CRP monitoring
27:00      Who to give Tocilizumab to
29:40     TACTIC trial
34:30     Why study SGLT2 inhibitors
37:00     The future Tx of Severe COVID
40:00     The JournalSpotting Gateway drug

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Have you been trying to keep up with the COVID literature, but too shattered after work these days to read anything except the local take out menu?

Your ears are in the right place, we help you get up to date on what you need to know in COVID-19, including:

TOCILIZUMAB: Why it's been approved and when you might be using it.

ICU DELIRIUM: Why you should put the benzos away and get the iPad out.

ASYMPTOMATIC TRANSMISSION:What percentage of your family actually had COVID at Christmas?

VENOUS THROMBOEMBOLISM:  Wondering why everyone is messing around with the prophylaxis dose?

OXYGEN: is it safe in the early 90's?

PRONING: what's the point and do patients actually do it?

ACE INHIBITORS: can we finally declare them safe in COVID?

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Want to know how to be more green at work, but you can only sigh as you plop your 1 millionth item of pristine plastic PPE from that morning into the bin?

Your ears are in the right place.

Today we interview Ms Chantelle Rizan; mountain biker, ENT fellow and environment warrior... She has published numerous articles on the topic of what healthcare does to our environment and, crucially, what we can do to improve it.

Timeline:
0200    Introducing Chantelle Rizan
0630   The situation with our environment
1130   Contribution of the NHS on the situation
1535   Impact of COVID pandemic on this
2130   The issues with surgery / theatres
2800   The role of waste disposal and recycling
3140   What is needed from organisation / government point of view?
3420  What can individual doctor do?
3910  Planetary Health edition of the Bulletin - thoughts and conclusions
4130  Take home points

Articles discussed:

The carbon footprint of waste streams in a UK hospital
The Carbon Footprint of Surgical Operations
Using surgical sustainability principles to improve planetary health and optimise surgical services following the COVID-19 pandemic

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

💊 STATINS...everyone's on them and lots of people stop them!

In this JournalChat, we caught up cardiologist Dr. James Howard, one of the co-authors of the SAMSON trial published in last months New England Journal of Medicine and featured in last months Round-Up.

James is a cardiology registrar at Imperial College, London. He chats to us about statin side effects, how the Nocebo effect might play a role, and how the SAMSON trial might help us better counsel patients about side effects. He also takes us behind the scenes of the N-of-1 trial design and we explore how it could be used in further trials and clinical practice.

❤️ The SAMSON trial was funded by the British Heart Foundation. 

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Trying to keep up with the general medicine literature but, in an environmentally friendly frenzy, you’ve used up all your shiny BMJs as wrapping paper?

Your ears are in the right place.

In this episode, Jon and Barney are joined by Alvin and Camille, and together we wade through the murky medical literature so you don't have to.

1) Blockbuster trial of the month: Semaglutide - the saviour of NASH? (04:40)
2) Bereavement and stroke - what is the link? (08:05)
3) Combo pill may, or may not, save us all (10:40)
4) Topic of the month: Statins in the elderly. Maybe the elderly benefit more than we think, and those side effects aren't as significant as your patient thinks... (13:10)
5) Which crystalloid in DKA? There can only be one winner. (19:00)
6) What's the link between sarcopenia and orthostatic hypotension? (21:18)
7) Natural remedies which might actually work in UC (24:05)
8) Inotropic drugs which could save lives in HFrEF (27:22)
9) Why you should check Vit D in your asthmatics (30:25)
10) Anticholinergic drugs and dementia risk (33:15)
11) A Case Study of ST elevation in a young patient (36:16)

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Have you been trying to keep up with the medical literature, but you’ve been too busy trying to keep track of vote counts for Biden in small counties in Arizona you’ve never heard of?

We have an awesome Round-Up of the key medical articles from September with Katia and Alvin! Enjoy!

--------------------------

Finerenone: FIDELIO-DKD trial
KDIGO guidelines
Nighttime BP and adverse cardiovascular events
NSBB cirrhosis
Iron - vitamin C and heart failure
SC-ICD; UNTOUCHED
Hyponatraemia- SALSA
Intermittent fasting trial: TREAT trial
Microbleeds and embolic stroke of unknown source
Naps for improving your brain function!

Irrelevant chat:
Chicken Dippaaaaz
Butterfield Diet

Find us on JournalSpotting.com, on Twitter / Facebook / Instagram @JournalSpotting

Leave a review on apple podcasts or email us any thoughts on [email protected]!

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Trying to keep up with COVID literature but there are more important things to consider, like, is your pumpkin carved as Trump even orange enough?

Your ears are in the right place.

COVID-19 is back (and never actually left)! After a blockbuster opening run in the first half of 2020 taking the world by storm, it’s back with a sequel that promises to be even bigger, even more gripping, and maybe even more deadly.

We’re back to bring you the latest key COVID literature updates you need to know as you head out the door in the morning to face COVID-19.

In this update we cover:

SOLIDARITY trial
RECOVERY trial
REACT working group
ACTT-1
Convalescent Plasma
4C Score
Case Fatality Rate
Face Masks in the population
At-risk patient groups: ILD, Asthama, Immunosuppression
Ventilation masterclass
Beards and FFP-3
COVID-19 and domestic Dogs

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Trying to keep up with the literature but you’re too exited IT'S AUTUMN! Whoo-Hoo!
Oh wait, it’s cold, wet, and Christmas is still months away.
At least we have conkers.
----------

We have an awesome Round Up of the key medical articles from September with Annalan and Katia! Enjoy!

Here are the timestamps:

Introductions                   01:00
Colchicine for the heart   04:50
SGLT2s for everyone!      08:30
Coffee in colorectal Ca    13:10
Tumeric for arthritis          15:50
Once weekly insulins       18:30
OOH Cardiac arrests        20:00
Giant Cell Arteritis            22:45
Pollution kills                    25:05
Morphine for COPD         29:00
Prasugrel vs Ticagrelor    31:45
Candy Case Study           35:42

Find us on JournalSpotting.com, on Twitter / Facebook / Instagram @JournalSpotting

Leave a review on apple podcasts or email us any thoughts on [email protected]!

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Trying to read up on Latent TB but the thought of wading through complicated literature about a dormant bug makes you wish you were, well, dormant? 

Your ears are in the right place!

A comprehensive Interview on everything you need to know about Latent TB with the mystical TB Guru of South London, Dr Ronan Breen!

0200 : Introductions
0300: Why Robber rob banks
0415: What is Latent TB (LTB)?
0600: LTB prevalence and who we should test
1145: IGRAs and our immune response
1230: Healthcare staff risk
1730: The patients choice
2110: Testing, Mantoux - pros and cons
2645: Progression to TB
3110: Excluding active TB
3930: Options for Tx
4430: CDC direction
4650: S/Es to watch for
5620: Future of LTB
5945: Take Homes

Literature:
NICE TB 2016 (updated 2019)
Risk of untreated LTB, BMJ
CDC treatment regimes
WHO on LTB

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!

Have you been trying to keep up with the medical literature, but its eat out to help out, and nothing is getting in the way of 50% your favourite pizza joint?

In this months episode:

..How to use D-dimers to diagnose cerebral venous thrombosis...(04:17)
Heldner, Mirjam R et al. “Prediction of cerebral venous thrombosis with a new clinical score and D-dimer levels.” Neurology vol. 95,7 (2020): e898-e909. doi:10.1212/WNL.0000000000009998

...Do we still need metronidazole for pneumonia?...(07:13)
Marin-Corral, Judith et al. “Aspiration risk factors, microbiology and empiric antibiotics for patients hospitalized with community-acquired pneumonia.” Chest, S0012-3692(20)31905-X. 17 Jul. 2020, doi:10.1016/j.chest.2020.06.079

...Ambulatory pneumothorax management...(09:45)
Hallifax, Rob J et al. “Ambulatory management of primary spontaneous pneumothorax: an open-label, randomised controlled trial.” Lancet (London, England) vol. 396,10243 (2020): 39-49. doi:10.1016/S0140-6736(20)31043-6

...SIADH management: more to it than just fluid restriction?... (16:37)
Krisanapan, Pajaree et al. “Efficacy of Furosemide, Oral Sodium Chloride, and Fluid Restriction for Treatment of Syndrome of Inappropriate Antidiuresis (SIAD): An Open-label Randomized Controlled Study (The EFFUSE-FLUID Trial).” American journal of kidney diseases : the official journal of the National Kidney Foundation vol. 76,2 (2020): 203-212. doi:10.1053/j.ajkd.2019.11.012

...How harmful are steroid bursts?... (22:15)
Yao, Tsung-Chieh et al. “Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study.” Annals of internal medicine vol. 173,5 (2020): 325-330. doi:10.7326/M20-0432

...Candesartan's role in cognitive decline... (25:11)
Hajjar, Ihab et al. “Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment: A Randomized Clinical Trial.” JAMA network open vol. 3,8 e2012252. 3 Aug. 2020, doi:10.1001/jamanetworkopen.2020.12252

...Weight loss: when do you go hunting for cancer?... (29:16)
Nicholson, Brian D et al. “Prioritising primary care patients with unexpected weight loss for cancer investigation: diagnostic accuracy study.” BMJ (Clinical research ed.) vol. 370 m2651. 13 Aug. 2020, doi:10.1136/bmj.m2651

...Baloxavir: the antiviral no ones talking about...yet...(33:15)
Ikematsu, Hideyuki et al. “Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts.” The New En

Support the show

Visit the website on www.journalspotting.com.
Follow us on Twitter @JournalSpotting.
Email us on [email protected].
Get our JournalClub App on https://journalclub.messly.com
Share us with all your colleagues!