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"'If we know activity, or sphere activity, at the time of delivery, and we know the dose to tumor, and we know the dose that we gave, we could figure out where the sphere concentrations are ... but we'd need to figure out what the dose to tumor is.' And he was like, 'Just do it in Simplicit90Y.' And at that point it was basically like, 'Oh, boom—just use the dosimetry tool we have to solve a problem. And so, that's where we are."—Tyler Sandow, MD

In this Journal of Vascular and Interventional Radiology (JVIR) audio episode, lead author Tyler Sandow, MD, speaks with journal Managing Editor Ana Lewis about his November 2024 paper, "Using Voxel-Based Dosimetry to Evaluate Sphere Concentration and Tumor Dose in Hepatocellular Carcinoma Treated with Yttrium-90 Radiation Segmentectomy with Glass Microspheres."

Related resources:

• Read the original article, "Using Voxel-Based Dosimetry to Evaluate Sphere Concentration and Tumor Dose in Hepatocellular Carcinoma Treated with Yttrium-90 Radiation Segmentectomy with Glass Microspheres," by Tyler Sandow, MD, Juan Gimenez, MD, Kelley Nunez, PhD, Richard Tramel, MD, Patrick Gilbert, MD, Brianna Oliver, MD, Michael Cline, MD, Kirk Fowers, PhD, Ari Cohen, MD, and Paul Thevenot, PhD
• Read the related commentary, "Known Unknowns: Gaps in Dose Distribution in Radioembolization, and in Our Understanding of Them," by A. Kyle Jones, MD
• Read the authors' response, "The Sphere Conundrum: Author’s Reply to Commentary on Voxel-Based Dosimetry with Glass Microspheres," by Tyler Sandow, MD, Juan Gimenez, MD, Kirk Fowers, PhD, and Paul Thevenot, PhD

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