In this episode, I speak with Dr. Inna about her journey from practicing high-level hospital medicine to discovering why she felt unwell despite normal labs. We explore how different healing traditions each offer valuable tools, why modern care often focuses on survival rather than thriving, and how true wellness begins with foundational changes in nutrition, lifestyle, gut health, and hormone balance before advanced therapies are considered.

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About the Guest:

Dr. Inna Lozinskaya is an internal medicine physician who spent decades in traditional hospital-based care before transitioning into functional medicine and longevity-focused practice. Drawing from training in Chinese medicine, Ayurveda, mind-body medicine, and integrative approaches, she now helps patients address root causes of chronic symptoms through personalized strategies focused on nutrition, lifestyle, and hormonal balance.

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Bismah Irfan, MD

Website: https://www.drbismah.com/about/

Facebook: https://www.facebook.com/KidneyHealthMD

Instagram: https://www.instagram.com/kidney.healthmd/

LinkedIn: https://www.linkedin.com/in/drbismah/

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PODCAST

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Dr. Bismah Irfan explains why fluid retention in kidney disease is a system-wide issue—covering kidney function, sodium, hormones, protein loss, lymphatic and gut health, plus practical management strategies.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients with kidney disease and complex immune conditions navigate personalized, evidence-based strategies to protect long-term health and prevent complications.

Bismah Irfan, MD

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In this episode of Wellness Focused, I walk through five subtle warning signs that your kidneys may be struggling long before you feel seriously ill—and why these signals are so often overlooked or dismissed.

After years of clinical practice, I’ve seen how frequently patients lose significant kidney function before anyone realizes what’s happening. In fact, it’s possible to lose up to 70% of kidney function before obvious symptoms appear. What makes this so concerning is that the early signs are usually present—but subtle, easy to normalize, and rarely connected back to kidney health.

I explain how changes like persistent foamy urine, unexplained swelling, deep fatigue that sleep doesn’t fix, shifts in urination patterns, and chronic itching can reflect underlying kidney stress. I also break down the physiology behind these symptoms, including how protein leakage damages kidney filters, how declining kidney function contributes to anemia and fatigue, and why nighttime urination can be an early red flag.

We also discuss why these signs are frequently attributed to aging, stress, or unrelated conditions—and how that delay in recognition can cost patients valuable time. This episode emphasizes why early investigation, comprehensive kidney testing, and self-advocacy can dramatically change outcomes.

This episode is meant to help patients and clinicians recognize that the body is always communicating—and that paying attention early can help protect kidney function before irreversible damage occurs.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients with kidney disease and complex immune conditions navigate personalized, evidence-based strategies to protect long-term health and avoid preventable complications.

Bismah Irfan, MD

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In this episode of Wellness Focused, I take a closer look at a hormone most kidney patients are never told to think about—testosterone—and why ignoring it may come at a real cost to kidney health.

Over years of clinical practice, I kept seeing men with chronic kidney disease who were doing everything “right,” yet their kidney function continued to decline. When I followed the research outside conventional nephrology training, a striking pattern emerged: low testosterone was common, rarely tested, and strongly linked to faster kidney deterioration, anemia resistance, muscle loss, and higher cardiovascular risk.

I walk through long-term studies showing how addressing testosterone deficiency can dramatically alter kidney outcomes, explain the biological mechanisms connecting hormones and renal function, and describe how kidney disease itself further suppresses testosterone—creating a self-perpetuating cycle.

I also discuss why standard care often misses this connection, which symptoms should raise concern, and which hormone tests actually matter. This is not about anti-aging or optimization trends—it’s about identifying a missing variable that may help stabilize kidney disease and improve quality of life when addressed thoughtfully and safely.

This episode is meant to help patients and clinicians look beyond assumptions and ask better questions about what may truly be driving kidney decline.

Low testosterone may accelerate kidney disease—Dr. Bismah explains the science, risks, and why hormone testing matters for men with CKD.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients with kidney disease and complex immune conditions navigate personalized, evidence-based strategies to protect long-term health and avoid preventable complications.

Bismah Irfan, MD

Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/KidneyHealthMD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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In this episode of Wellness Focused, Dr. Bismah Irfan reveals how some commonly recommended “healthy” dietary habits may actually accelerate kidney damage—especially in individuals with early or moderate kidney dysfunction.

Dr. Bismah explains that kidneys under stress process nutrients very differently, and that standard nutrition advice can unintentionally increase toxic waste buildup, inflammation, and scarring of delicate kidney blood vessels.

She breaks down three hidden kidney stressors:

• Excessive animal protein, which increases urea and creatinine load and generates kidney-damaging Advanced Glycation End Products (AGEs), especially when grilled or fried
• High-sodium processed foods, including “healthy” whole-grain breads and cereals that silently drive protein leakage in urine
• Phosphate additives, which are nearly 100% absorbed, promote vascular calcification, weaken bones, and accelerate kidney decline

Dr. Bismah also shares practical, realistic swaps—such as favoring plant-based proteins, rinsing canned foods to dramatically reduce sodium, and learning how to spot hidden “PHOS” additives on labels.

Most importantly, she highlights a real-world success story of a patient with Stage 3 kidney disease who improved her GFR by 8 points in just six months by reducing processed foods and lowering her kidney’s daily burden.

This episode empowers listeners to make smarter, kidney-protective nutrition choices that reduce strain, slow disease progression, and support long-term renal health.

Dr. Bismah Irfan explains how excessive animal protein, hidden sodium, and phosphate additives can accelerate kidney damage—and what to eat instead to protect kidney function.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients with kidney disease understand how nutrition, lifestyle, and medical care intersect—so they can slow disease progression, avoid preventable damage, and protect long-term health.

Bismah Irfan, MD

Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/KidneyHealthMD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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In this episode of Wellness Focused, Dr. Bismah Irfan uncovers a critical and often overlooked consequence of anti-CD20 therapies such as Rituximab, Ocrelizumab, and Ofatumumab: long-term immune memory loss.

While these medications are life-saving for conditions like kidney disease, autoimmune disorders, and cancer, they work by eliminating B cells—the immune cells responsible for remembering past infections and vaccines. Emerging research now shows that for many patients, these cells do not fully recover, even years after treatment ends.

Dr. Bismah reviews compelling long-term studies revealing persistent depletion of memory B cells, loss of vaccine protection, low recovery rates, and serious clinical consequences such as recurrent infections and increased mortality. She explains why “young” B cells may return while switched memory B cells fail to regenerate, and how bone marrow damage, chronic inflammation, and overlapping immunosuppressive therapies may contribute.

Most concerning, Dr. Bismah highlights a major blind spot in modern medical care: the majority of patients receiving anti-CD20 therapy never have their immunoglobulin levels or B-cell subsets monitored, leaving them vulnerable without knowing it.

This episode empowers patients and clinicians with practical steps—testing, monitoring, and informed advocacy—to protect immune health while navigating necessary treatment.

Dr. Bismah Irfan explains how anti-CD20 therapies can cause long-term immune memory loss, vaccine failure, infection risk, and why immune monitoring is essential.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients with kidney disease and complex immune conditions navigate personalized, evidence-based strategies to protect long-term health and avoid preventable complications.

Bismah Irfan, MD

Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/KidneyHealthMD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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In this episode of Wellness Focused, Dr. Bismah Irfan exposes the hidden dangers of the multi-billion-dollar detox and supplement industry—particularly its impact on kidney health. She explains why the term “natural” is a marketing label, not a safety guarantee, and how many popular cleanses place dangerous stress on the kidneys.

Dr. Bismah breaks down the myth of detoxing, clarifying that the body already has highly efficient filtration systems—the liver and kidneys—and that concentrated herbal supplements only increase their workload. She also explores the regulatory “grey zone” created by the DSHEA Act of 1994, which allows supplements to be sold without proof of safety or effectiveness.

Through real clinical cases, Dr. Bismah shares how a so-called “kidney cleanse” led to irreversible kidney decline in one patient, while a juice cleanse caused life-threatening potassium levels and emergency dialysis in another.

Rather than miracle cures, she emphasizes evidence-based kidney support: hydration with plain water, whole foods over juices, controlling blood pressure and diabetes, and individualized care guided by a physician.

Dr. Bismah Irfan reveals why detoxes and “natural” supplements can harm kidneys, explains supplement industry risks, and shares safe, evidence-based kidney support strategies.

Bismah Irfan, MD

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In this episode of Wellness Focused, Dr. Bismah Irfan exposes a hidden danger in renal care: many foods promoted as “superfoods” can accelerate kidney damage in patients with impaired function. She explains why generic health advice can be toxic without considering an individual’s kidney health.

Dr. Bismah discusses the “Green Smoothie Paradox,” where high-oxalate greens like spinach and kale can form calcium-oxalate crystals in the kidneys, triggering inflammation and fibrosis. She also highlights other “health halo” foods—brown rice, whole grains, starfruit, coconut water, and protein shakes—that can be risky for kidney patients.

Protective strategies include choosing low-oxalate greens, ensuring adequate calcium intake to bind oxalates, and monitoring hydration and electrolyte-rich drinks. Personalized nutrition, she emphasizes, is essential: what heals a healthy person may harm a struggling kidney.

Dr. Bismah Irfan explains why “superfoods” like spinach, kale, and coconut water can harm kidneys, and provides kidney-safe nutrition strategies for optimal health.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients with kidney disease navigate personalized nutrition strategies to protect their kidneys while still enjoying a balanced, health-supportive diet.

Bismah Irfan, MD

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In this episode of Wellness Focused, Dr. Bismah Irfan explains why many patients with chronic illness—especially kidney disease—feel fatigued and unwell even when their standard blood tests appear normal.

She reveals that conventional medicine often measures the quantity of immune cells, but the true story lies in their quality and balance. Chronic immune activation combined with innate immune depletion creates a hidden pattern of overworked T-cells and exhausted Natural Killer (NK) cells.

Dr. Bismah outlines common invisible triggers for immune exhaustion, including viral reactivation (EBV, CMV), mold and mycotoxins, heavy metals, and chronic stress. This "inflammatory soup" damages kidney filters, inflames the gut-kidney axis, and can even promote autoimmune attacks on kidney tissue.

She provides a structured action plan for recovery, including specialized immune testing, environmental detox, and targeted support with nutrients and medicinal mushrooms to restore immune balance and kidney resilience.

Dr. Bismah Irfan reveals why standard blood work can miss hidden immune exhaustion, the effects on kidney health, and a three-step approach to restore T-cell and NK cell function.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients uncover hidden immune dysfunction, reduce systemic inflammation, and restore kidney and overall health with targeted testing, environmental interventions, and nutrient support.

Bismah Irfan, MD

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In this episode of Wellness Focused, Dr. Bismah Irfan challenges conventional thinking about heart and kidney health, revealing that vascular disease is driven by clotting, inflammation, and metabolic dysfunction—not just cholesterol.

She explains how arterial plaques are primarily composed of fibrin, platelets, inflammatory debris, and cholesterol trapped from red blood cells, rather than circulating LDL. Dr. Bismah highlights the intimate connection between the heart and kidneys, showing that patients with chronic kidney disease are up to 10 times more likely to die from cardiovascular events.

Dr. Bismah identifies the five systemic forces damaging blood vessels: chronic inflammation, oxidative stress, endothelial dysfunction, abnormal clotting, and metabolic dysfunction. She provides actionable strategies, including advanced blood testing (Oxidized LDL, Lipoprotein(a), Fibrinogen, Homocysteine, High-Sensitivity CRP), dietary changes, lifestyle support, and treating hidden infections.

By addressing the vascular system holistically, patients can improve both heart and kidney function simultaneously, rather than treating organs in isolation.

Dr. Bismah Irfan reveals the hidden causes of heart and kidney disease, including clotting, inflammation, and metabolic dysfunction, and shares personalized strategies for vascular health beyond cholesterol.

I’m Dr. Bismah Irfan, MD, a board-certified nephrologist and functional medicine physician. I help patients optimize heart and kidney health by addressing systemic causes of inflammation, metabolic dysfunction, and vascular damage.

Bismah Irfan, MD

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