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This episode reviews a 2026 pilot study evaluating the effects of photobiomodulation therapy (PBMT) on inflammatory and cartilage biomarkers in patients with advanced knee osteoarthritis. We discuss the biologic rationale for PBMT, changes in serum and synovial fluid cytokines, and whether these findings move PBMT closer to being considered a disease-modifying intervention rather than simply a symptomatic treatment.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12972950/#sec1-2
Ferreira, Nathalia Lopes et al. “Photobiomodulation Therapy Modulates Inflammatory and Cartilage Biomarkers in Patients with Knee Osteoarthritis: A Pilot Case Series.” Journal of orthopaedic case reports vol. 16,3 (2026): 315-321. doi:10.13107/jocr.2026.v16.i03.6980
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Joining us today is Tommy Mulhern — Physician Associate, Marine Corps Veteran, and emerging voice in the field of psychedelic-assisted therapy. Tommy and Dr. Rountree served together in the Marines and recently reconnected over their shared interest in advancing healthcare. After years working in conventional medical roles, Tommy became increasingly aware of healthcare's shortcomings in addressing mental and emotional suffering. Guided by his own healing journey and work with ketamine and psilocybin-assisted therapy, he now devotes himself to bridging conventional medicine and natural medicines — helping individuals access deeper, more complete healing while contributing to the growing movement advancing safe and accessible psychedelic care.
As discussed in the podcast, screening and post-experience integration are essential for successful treatment. Tommy provides information and clinical screening for patients seeking psychedelic-assisted therapy to improve outcomes for patients with PTSD, depression, and addiction. You can learn more at his website themedicinemarine.com or simply email him directly at: [email protected]
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In this episode, we review a 2026 systematic review and meta-analysis examining the effects of photobiomodulation (PBM) on depressive symptoms. We break down the mechanisms, results, and practical clinical applications of this emerging, non-invasive therapy.
Ji-Woo Seok, Kahye Kim, Jaeuk U. Kim, Jung-Dae Kim, "Effect of photobiomodulation intervention for depressive symptoms: A systematic review and meta-analysis," Journal of Affective Disorders,
Volume 393, Part B, 2026, 120413, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2025.120413
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HEALTHCARE PROVIDERS! It's a classic face-off episode, where we compare sound vs light. Which one comes out ahead? Where do you spend your money to help the most patients? Tune in and learn what the latest research is saying!
Read the full study discussed in this episode --
Extracorporeal Shockwave Therapy versus laser therapy in treating musculoskeletal disorders: a systematic review and meta-analysis
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Plantar Fasciitis is a common cause of heel pain, affecting many. You likely have patients struggling with this painful issue. If you use a Class 4 laser for your patients you may wonder what settings work best. Listen to this episode as Dr. Rountree, DC, CMLSO discusses this new 2024 study on high power vs. higher power laser for plantar fasciitis.
Read the full study discussed in this episode --
Photobiomodulation Therapy Plus Usual Care Is Better than Usual Care Alone for Plantar Fasciitis: A Randomized Controlled Trial
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In this episode, Dr. Rountree discusses a newly released study detailing photobiomodulation and various brain disorders.
Read the full study discussed in this episode --
Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends
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View the many other episodes and videos available here Laser Therapy Institute
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Plantar fasciitis can be tough to treat but can be even more difficult when a calcaneal spur is present. In this double-blind, placebo-controlled trial, laser therapy showed some great benefits. Listen in as we summarize the study and give you takeaways to help your patients!
We are now live-streaming each recording on YouTube! Watch the recording of this episode.
(Be sure to catch our Healing at the Speed of Light Podcasts on YouTube!)
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View the many other episodes and videos available here Laser Therapy Institute
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Success with Laser Therapy Flowchart & Checklist Infographic
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Read about laser research on the LTI Blog
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Find out how you can Customize your LTI experience
Are you trying to sort through all the research and information about lasers? Let us help!
In this episode, we go over the results of more than 170 studies about the cellular and tissue effects of different wavelengths. Learn what the research is showing for visible and infrared wavelengths so you can decide for yourself which lasers fit your practice, in a plain-language way that makes sense!
We do a live broadcast of the LTI Podcast every other week on Facebook. Watch this episode here.
(Be sure to also catch our Healing at the Speed of Light Podcast on Facebook!)
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Laser Therapy Institute
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Success with Laser Therapy Flowchart & Checklist Infographic
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Read about laser research on the LTI Blog
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Find out how you can Customize your LTI experience
Laser therapy has been proven to help with diabetic neuropathy pain, but could lasers stimulate damage reversal? Join us as we review the research on neurovascular function in diabetic neuropathy.
Read the full research study mentioned in this episode.
We do a live broadcast of the LTI Podcast every other week on Facebook. Watch this episode here.
(Be sure to also catch our Healing at the Speed of Light Podcast on Facebook!)
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Laser Therapy Institute
Further Resources:
Success with Laser Therapy Flowchart & Checklist Infographic
Check out these FREE Provider Resources
Read about laser research on the LTI Blog
Learn more about what we offer on the LTI website
Find out how you can Customize your LTI experience
Do you use, or want to use, laser therapy to treat patients with carpal tunnel syndrome? How can you be sure your dose parameters and technique are correct? Join us to hear what recent research is showing for LLLT and HILT doses for effective treatment!
Read the full study here.
We do a live broadcast of the LTI Podcast every other week on Facebook. Watch this episode here.
(Be sure to also catch our Healing at the Speed of Light Podcast on Facebook!)
YouTube Channel
Laser Therapy Institute
Further Resources:
Success with Laser Therapy Flowchart & Checklist Infographic
Check out these FREE Provider Resources
Read about laser research on the LTI Blog
Learn more about what we offer on the LTI website
Find out how you can Customize your LTI experience
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