Brendan Dassey was featured on Making a Murderer. Nirider featured in the final episode of the first season of the documentary, which propelled her to fame among fans of the show thanks to her commitment to the cause and strong, intelligent demeanor. She is featured throughout the second series as it chronicles the CWCY's efforts to remove Dassey's confession being confirmed as evidence, the only piece of evidence that links him to the murder of Teresa Halbach.

Nirider has stated that one of her reasons for entering juvenile law (in particular, focusing on false confessions) was her involvement in the Dassey case while Drizin's a postgraduate student in 2007. Even while working briefly in commercial law Nirider continued to contribute to the Dassey case. Dassey remains behind bars; however, efforts to prove that his confession was extracted through unsuitable methods, with Nirider and Drizin at the helm, remain ongoing. Nirider is strongly critical of the methods used to interrogate a vulnerable and "mentally-limited" 16-year-old, as well as Dassey's previous legal representation.

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