Psychology in the Classroom

Learning from Failure: The Biological Case for Embracing Mistakes


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In this episode of Psychology in the Classroom, Dr. Lauren Margulieux helps explore why failure isn't just a learning opportunity—but a biologically powerful one. Drawing on neuroscience, Lauren explains how our brains react to failure, the role of neurotransmitters like epinephrine and acetylcholine, and why moderate emotional discomfort can actually prime the brain for better memory and attention.

We discuss:

  • How to help students frame failure positively

  • Why emotional regulation is key to learning

  • Practical strategies for secondary teachers to support learning in the face of setbacks

  • The impact of daily cycles, sleep, exercise, and nutrition on focus and cognitive performance

Packed with practical tips and grounded in cutting-edge science, this episode is a must-listen for any teacher supporting adolescent learners through challenges—especially during exam season.

Resources & Links

🔗Margulieux, Lauren & Prather, James & Rahimi, Masoumeh. (2025). The Biological Benefits of Failure on Learning and Tools to Manage the Fallout. Educational Psychology Review. 37. 10.1007/s10648-025-10013-7. https://link.springer.com/article/10.1007/s10648-025-10013-7

🔗L. E. Margulieux, J. Prather, M. Rahimi and G. C. Uzun, "Leverage Biology to Learn Rapidly From Mistakes Without Feeling Like a Failure," in Computing in Science & Engineering, vol. 25, no. 2, pp. 44-49, March-April 2023, doi: 10.1109/MCSE.2023.3297750.,(practitioner-focused paper, 5 pages): https://doi.org/10.1109/MCSE.2023.3297750

🔗Learn more about Dr. Lauren Margulieux's work: https://laurenmarg.com/

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