Happy Valentine's Day!

We're kicking off 2024 by sharing a fun interview with Dr. Camille Zenobia (@oralhealthactivist on IG), co-founder of OSSA, and the lovely co-host of Let's Get Oral. Join us to learn more about her life journey before she met Jonathan @ Colgate-Palmolive and what motivated her to launch an oral beauty care company.

Check out OSSA Care for their toothpaste and mouth serum products available now!

• Instagram: ossacare
• LinkedIn: Os Salutem

Please help us spread the word about Let's Get Oral by letting your family and friends know about us! Hit that share button, subscribe if you're not already a regular listener, and give us a quick review on Apple Podcasts or wherever you listen to us.

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Keep smilin' everyone!

The geroscience guru is here! On this episode, Dr. Jonathan An joins the LGO crew to discuss the intersection of oral health and aging, how geroscience is expanding our knowledge of oral inflammation, and so much more.

Dr. An is a dental research physician focused on understanding the basic biological mechanisms of aging in oral health and disease. He currently serves as Assistant Professor of Oral Health Sciences and Faculty in the Healthy Aging and Longevity Institute at the University of Washington School of Dentistry.

Listen now on Apple, Spotify, Google Podcasts, any other podcast platform, or directly from our website here!

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Are you wondering what to do with all of your leftover Halloween treats? Perhaps you are unsure how these scary, yet yummy sweets may affect your pretty pearls?

In this episode, we explore the scary myths and truths of dental cosplay, which treats are better or worse for teeth, and when is the best time to brush.

Show Notes:

1. Whitening Popups and state regulations on whitening services
2. The NIDCR reports that adults 20-64 have an average of 25.5 teeth!
3. 2.2% of US adults have NO teeth
4. Best Types of Treats for Teeth = chocolate, sugar-free, and nut candies
5. Moderate evidence shows e-brushes are more effective at removing plaque
6. However, e-brushes are also more likely to abrade dentin

If you want to learn more about the links between oral and systemic health, follow Let's Get Oral here on LinkedIn and subscribe to our pod on your favorite streaming platform to stay informed!

Probiotics are living microorganisms that provide health benefits when consumed in adequate amounts. These beneficial bacteria are known to support digestion, enhance immune function, and promote overall well-being. In recent years, probiotics have gained significant popularity, leading to the development of a wide range of products aimed at delivering these beneficial microorganisms to consumers.

In this episode, Camille and Jonathan further explore the existing research, safety, and consumer landscape of oral probiotics. Below are some notes we refer to throughout this episode:

• Lactobacillus salivarius tablets (Nishihara et al 2014) have shown the ability to reduce the risk of tooth decay.
• Clinical study w/ inactivated Lactobacillus plantarum L137 capsules showed probiotics can reduce pocket depth in patients undergoing supportive periodontal therapy (Iwasaki et al 2016).
• L. rhamnosus GG + Bifidobacterium lactis BB12 lozenges were evaluated for anti-gingival and biofilm effects in healthy adolescents (Alanizi et al 2018).
• L. reuteri 2x chewing gum reduced OLT scores after two weeks of use (Yoo et al 2019) and L. salivarius probiotics helped control bad breath and related factors (Suzuki et al 2014).

Want more from us? Follow us on Instagram (@letsgetoral) or our website (Let's Get Oral) to stay informed!

There has been a lot of discussion in recent years about the role of the oral microbiome in heart health. Recent studies have indicated that oral bacteria are essential for nitric oxide production. What does this mean? How is this related to heart health?

In this episode, we dive deep into the roles nitric oxide (NO) plays in cardiovascular and oral health. We go over the basics of NO biology, the role of the oral microbiome in NO production, and how the disruption of this relationship can impact our health.

Please help us spread the word about Let's Get Oral by letting your family and friends know about us! Hit that share button, subscribe if you're not already a regular listener, and give us a quick review on Apple Podcasts or wherever you listen to us.

Follow us on Instagram and LinkedIn to stay informed on new episodes, announcements, and breaking news in oral health.

Keep smilin' everyone!

In this episode, Camille and Jonathan explore all things oral inflammation!

Since the previous episode with Dr. Glogauer touched A LOT on this topic, we want to chat about the how, why, and what to do about oral inflammation.

Additional Tidbits:

• Intermittent fasting and perio health
• Footballers and oral health

Please help us spread the word about Let's Get Oral by letting your family and friends know about us! Hit that share button, subscribe if you're not already a regular listener, and give us a quick review on Apple Podcasts or wherever you listen to us.

Follow us on Instagram and LinkedIn to stay informed on new episodes, announcements, and breaking news in oral health.

Keep smilin' everyone!

We talked with Dr. Glogauer (Michael) about saliva, his new diagnostic!!!!!!!!!!, and the issue of inflammation. 

The Questions we had for him:

You’re currently working on a chair side device that measures inflammation-

1. What started you on the path to developing this device?
2. What do you think the benefit will be for the providers using this assay?
3. What is the most surprising thing you learned during the development process?
4. Most salivary diagnostics outside of infectious disease run up against the issue of person to person variability, especially around inflammatory cytokines. How is your device different or how have you been able to address this common issue? 
5. One of the most compelling pieces of your work is your observation that oral inflammation is intimately tied to the immune profile of the circulating cells. Can you tell us more about your work in this space?
6. Do you think there is a role for your chair side assay in tracking circulatory health?
7. There is currently a lot of activity in diagnostics for analysis of the oral microbiome. I have my skepticism but I do see a potential to create a more robust opportunity by mixing the two tests- inflammation and microbiome analysis. The way I see it is this: oral inflammation can drive dysbiosis and create potential for chronic pathology and therefore, if you have a positive inflammation test with a micro test that shows increase to pathogen profile, risk for progression of pathology is certain. However, I am still unsure if we really need to know exactly which bacteria are present. I think of inflammation as the primary driver. Can you tell us your thoughts on combining tests - how they might be (or not) useful for the clinician and/or patient?

Additional Questions:

1. Do you think there are potential applications for this salivary Dx beyond oral health? (e.g. fitness/recovery assay for professional athletes)
2. Could you share some insights into what inspired your journey as an entrepreneurial research physician?
3. How do you envision the realm of dentistry and oral health will look in 2050? What do you think are the biggest challenges oral health faces during this window of time?
4. How long have you played bass guitar? Are you in a band?

Camille and Jonathan nerd out over SALIVA. We have a lot of experience to pull from which can be a little gross but a lot of fun! This episode discusses the foundation of salivary biology and where we are at with salivary diagnostics.

Please help us spread the word about Let's Get Oral by letting your family and friends know about us! Hit that share button, subscribe if you're not already a regular listener, and give us a quick review on Apple Podcasts or wherever you listen to us.

Follow us on Instagram and LinkedIn to stay informed on new episodes, announcements, and breaking news in oral health.

Keep smilin' everyone!

Show Notes:

• https://myfitstrip.com/
• ‘Persistent salivary gland hypofunction often leads to an increased activity of caries with lesions on cervical, incisal and cuspal tooth surfaces, dental erosion, mucosal changes and oral fungal infections’ https://onlinelibrary.wiley.com/doi/full/10.1111/odi.12867 
• ‘The rate of alpha-amylase secretion was influenced by mastication in accord with digestive function, in that more secretion was induced by food than by nonfood stimuli, more by bread than by celery, and more by larger than smaller pieces of bread.’ https://doi.org/10.1016/0031-9384(90)90131-M 
• ‘Ghrelin (hunger hormone) in saliva is produced and released by salivary glands. The effect of ghrelin on oral cell proliferation adds to the pro-proliferative action of other salivary growth factors.’ https://doi.org/10.1373/clinchem.2004.040667 
• Chewing gum can help stabilize GLP-1, upstream, and reduce feelings of hunger https://link.springer.com/article/10.1007/s12020-015-0566-1 

Camille and Jonathan nerd out over taste buds, flavor science, and how our senses impact our oral health!

Please help us spread the word about Let's Get Oral by letting your family and friends know about us! Hit that share button, subscribe if you're not already a regular listener, and give us a quick review on Apple Podcasts or wherever you listen to us.

Follow us on Instagram and LinkedIn to stay informed on new episodes, announcements, and breaking news in oral health.

Keep smilin' everyone!