Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Dr Xinxin Yang, University of Oxford, UK. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Xinxin Yang. Dr Xinxin Yang is a qualitative researcher in the Department of Primary Care Health Sciences, University of Oxford. She is part of the Tobacco Addiction Group within the Centre for Evidence-Based Medicine. Dr Xinxin Yang is a Conversation Analyst on the TRIDENT (Tobacco RIsk reDuction with E-cigarette Nicotine Replacement Therapy) project, which aims to develop and deliver tailored smoking harm reduction interventions for people with serious mental illness in routine mental healthcare. In the April 2026 podcast Xinxin talks to Nicola Lindson about conversation analysis work on the MaSC study (Management of Smoking in Primary Care). In the MaSC study usual care was compared to brief advice and an offer to try an e-cigarette. The numbers of participants who reduced and quit smoking were measured at follow-up. She describes how the findings from MaSC will be used to design a communication guide that will be used to train the clinical professionals to deliver the offer of an e-cigarette for the TRIDENT trial. In TRIDENT consultations between the clinicians delivering the offer of e-cigarettes to patients will then be recorded and analysed with conversation analysis. Xinxin explains how this will provide some of the first real-world evidence on how to deliver smoking reduction intervention effectively for people with serious mental illness. This could prove to be valuable for clinicians and also for the service users. The findings may feed into a larger scale trial to be conducted across the UK.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches.

Our searches for the EC for smoking cessation review carried out on 1st April 2026 found: 3 linked reports (10.1158/1940-6207.CAPR-25-0244, 10.1016/j.addbeh.2026.108672, 10.64898/2026.03.18.26348637).

Our search for our interventions for quitting vaping review carried out on 1st April 2026 found: 1 linked report (10.2196/79667).

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in November 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub10/full

For more information on the full Cochrane review of Interventions for quitting vaping published in November 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub3/full