Let's talk e-cigarettes

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Stephen Higgins from the University of Vermont Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Stephen Higgins from the University of Vermont Tobacco Center of Regulatory Science, Burlington, USA. Professor Stephen Higgins uses the concepts and methods of behavioural economics and behavioural pharmacology to investigate tobacco, illicit drugs, and other health-related risk behaviours in vulnerable populations.

In the October podcast Stephen Higgins describes his recent studies on reduced nicotine cigarettes and e-cigarettes in high-risk populations. Their three randomised clinical trials involved 326 participants. They found that decreases in cigarettes smoked daily, resulting from smoking cigarettes with reduced nicotine content, were significantly larger when adults from at-risk populations had access to e-cigarettes in their preferred flavours. Their study findings indicate that access to preferred flavoured e-cigarettes has the potential to enhance the effect of a nicotine-reduction policy on cigarette smoking in populations with psychiatric conditions or lower education level who are at greatest risk for smoking and associated harm.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st October found: 2 new studies. The study by Higgins et al described on this podcast (DOI: 10.1001/jamanetworkopen.2024.31731) and DOI: 10.1093/ntr/ntae212. We also found 3 linked papers (10.2196/58260, 10.1111/add.16633, 10.1038/s41415-024-7850-5)

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping.

Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours.

In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers.

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping.

Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours.

In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers.

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jamie Brown, University College London Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jamie Brown. Jamie Brown is Professor of Behavioural Science and Director of the Tobacco and Alcohol Research Group at University College London. He co-leads a research programme that aims to provide insights into population-wide influences on smoking, smoking cessation and alcohol reduction via management and analysis of the major population surveys, the Smoking and Alcohol Toolkit Study. He is also involved in the development of digital behaviour change technologies. His particular focus is on real-world monitoring and evaluation of national tobacco control and alcohol policies, events and stop smoking treatments including e-cigarettes and nicotine replacement therapy.

In this podcast Jamie describes how he became involved in this research field. Jamie talks about the national surveillance programme, the Smoking Toolkit Study in relation to e-cigarettes. The Smoking Toolkit Study aims to monitor trends and provide insights into population wide influences on smoking and smoking cessation and be representative of adults in Great Britain. Each month a new sample of about 2400 adults complete a detailed survey with a trained Ipsos Mori interviewer. The study was started by Professor Robert West, almost 20 years ago in 2006 and has accumulated data from almost 400,000 different adults. This is an open toolkit or resource and the data is intended to be used by other researchers, policy makers and practitioners. Jamie talks about the different kinds of information that can be gathered from surveys compared to randomized controlled trials and discusses the importance of gathering data from different sources, to enhance the credibility of research findings.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st July found: found 2 new studies (DOI:10.1001/jamainternmed.2024.1822; DOI: 10.1158/1538-7445.AM2024-LB086), 1 new ongoing study (NCT03862924) & 4 linked papers.

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jamie Brown, University College London Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jamie Brown. Jamie Brown is Professor of Behavioural Science and Director of the Tobacco and Alcohol Research Group at University College London. He co-leads a research programme that aims to provide insights into population-wide influences on smoking, smoking cessation and alcohol reduction via management and analysis of the major population surveys, the Smoking and Alcohol Toolkit Study. He is also involved in the development of digital behaviour change technologies. His particular focus is on real-world monitoring and evaluation of national tobacco control and alcohol policies, events and stop smoking treatments including e-cigarettes and nicotine replacement therapy.

In this podcast Jamie describes how he became involved in this research field. Jamie talks about the national surveillance programme, the Smoking Toolkit Study in relation to e-cigarettes. The Smoking Toolkit Study aims to monitor trends and provide insights into population wide influences on smoking and smoking cessation and be representative of adults in Great Britain. Each month a new sample of about 2400 adults complete a detailed survey with a trained Ipsos Mori interviewer. The study was started by Professor Robert West, almost 20 years ago in 2006 and has accumulated data from almost 400,000 different adults. This is an open toolkit or resource and the data is intended to be used by other researchers, policy makers and practitioners. Jamie talks about the different kinds of information that can be gathered from surveys compared to randomized controlled trials and discusses the importance of gathering data from different sources, to enhance the credibility of research findings.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st July found: found 2 new studies (DOI:10.1001/jamainternmed.2024.1822; DOI: 10.1158/1538-7445.AM2024-LB086), 1 new ongoing study (NCT03862924) & 4 linked papers.

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Louise Ross from the National Centre for Smoking Cessation and Training (NCSCT). Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Louise Ross from the National Centre for Smoking Cessation and Training (NCSCT).

Louise Ross has worked in smoking cessation for over 20 years and consults for the NCSCT, and is part of the senior team on the Smoke Free App, a digital service for helping people stop smoking. NCSCT is a social enterprise committed to supporting the delivery of effective evidence-based tobacco control programmes and smoking cessation interventions provided by local stop smoking services, and by colleagues in the NHS and the social care sector.

For further information about NSCST: https://www.ncsct.co.uk/

Louise Ross talks about the swap to stop scheme that aimed to reach a million people who smoke to give them a chance to switch less harmful vapes. The swap to stop training is not only for qualified stop smoking practitioners but is also aimed at the frontline services working with for example debt management teams within social housing, homelessness, substance use, and other groups. The training models how to raise the subject of quitting smoking and swap to stop. A four week supply of e-liquid is provided and, if funds are available, a 12 week supply. People are advised how much they should use their vape and to use an e-liquid that is strong enough to manage their withdrawal symptoms, as they would be with nicotine replacement therapy. They are also advised not to stop using a vape too soon as they may go back to tobacco smoking.

Jamie and Nicola discuss ongoing work on brief opportunistic advice in financial support settings. The scoping review mentioned is available here: https://onlinelibrary.wiley.com/doi/full/10.1111/add.16533

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st June found:

One linked study: Leavens E.; Nollen N, Ahluwalia J, Mayo M, Rice M, Brett E, Pulvers K. Changes in dependence, withdrawal, and craving among adult smokers who switch to nicotine salt pod-based e-cigarettes, Journal of Clinical and Translational Science / 2021;5(Supplement 1):85-86, DOI: 10.1017/cts.2021.622

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Andrea Villanti. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Associate Professor Andrea Villanti, Department of Health Behavior, Society, and Policy, Rutgers School of Public Health. Andrea Villanti's research focuses on young adult tobacco use including predictors and patterns of use and interventions to reduce tobacco use in young adults. Dr Villanti describes their randomised controlled trial to test the effect of three exposures to eight nicotine corrective messages on beliefs about nicotine, nicotine replacement therapy, e-cigarettes and reduced nicotine content cigarettes at 3-month follow-up. Their study concluded that repeated exposure to NCM was necessary to reduce false beliefs about nicotine and tobacco products and is reported in Tobacco Control e-publication, doi:10.1136/ tc-2023-058252.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st May found:

One new study by Rabenstein A et al, Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial. European Addiction Research / 2024;(c60, 9502920):1-9

Three new ongoing studies: NCT06372899; NCT06373679 and Polosa et al, Protocol for the "magnitude of cigarette substitution after initiation of e-cigarettes and its impact on biomarkers of exposure and potential harm in dual users" (MAGNIFICAT) study, Frontiers in Public Health / 2024;12(101616579):1348389, DOI 10.3389/fpubh.2024.1348389

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jaqueline Avila. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jaqueline Avila from the Department of Gerontology, University of Massachusetts Boston, USA. Professor Avila describes their pilot study to assesses the harm-reduction potential of e-cigarettes and oral nicotine pouches among people who smoke with low socioeconomic status. This pilot of 45 people provides novel evidence that e-cigarettes and nicotine pouches can be a harm-reduction tool for individuals with lower SES who smoke and are not willing to quit smoking, contributing to reducing tobacco-related disparities in this population. This study is funded by Brown University.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st April found:

Avila JC, Maglalang DD, Nollen N, Lee SC, Suh R, Malone M, Binjrajka U, Ahluwalia JS, Using pod based e-cigarettes and nicotine pouches to reduce harm for adults with low socioeconomic status who smoke: a pilot randomized controlled trial Nicotine & tobacco research 2024. 10.1093/ntr/ntae047. Featured in our podcast.

Four papers linked to studies included in the review: Belderson et al 2024, DOI 10.1136/bmjopen-2023-078677; Liu et al, 2024, DOI 10.1001/jamainternmed.2024.1125; Yingst et al 2024, DOI 10.1136/tc-2023-058282; Conte et al 2024, DOI 10.2196/53222. Two new ongoing studies: NCT06264154 and NCT06260683

For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Ian Pope. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Ian Pope, an emergency medicine physician and honorary associate professor at Norwich Medical School, about his new trial, which he co leads with Professor Caitlin Notley from the University of East Anglia. The new trial is the COSTED trial, the Cessation of Smoking Trial in the Emergency Department and funded by the British National Institutes of Health Research. This is a multi-centre randomised controlled trial, based in 6 emergency departments around the UK. This study tested the real-world effectiveness of an emergency department based smoking cessation intervention that included provision of an e-cigarette starter kit compared to usual care. (ClinicalTrial.gov:NCT04854616). Adults who smoke tobacco and were attending one of six EDs across the UK were randomised to either control (in which case they were given written information about stop smoking services) or intervention (brief smoking cessation intervention, provision of an e-cigarette starter kit, and referral to stop smoking services). Both groups were followed up 1, 3 and 6 months after randomisation. Smoking abstinence was biochemically verified at 6 months. There were over a thousand participants and biochemically verified smoking cessation rate of 7.2% in the intervention group 4.1% in the control group. The study found that it was feasible to implement a smoking cessation intervention in EDs with dedicated staff time to deliver the intervention and that EDs may represent an excellent opportunity to engage hard to reach smokers.

Pope I, Notley C, Boyle A, Results of the cessation of smoking trial in the emergency department (COSTED), Emergency Medicine Journal / 2023;40(12):873-874

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st March found the following

1 new study:

Hoeppner BB, Eddie D, Schick M, Hoeppner SS, Kelly L, Kelly JF, Feasibility of and reactivity to ecological momentary assessment (EMA) during electronic cigarette use initiation in adults who smoke daily: MASKED FOR REVIEW, European Journal of Psychiatry / 2024;38(3):100247. 10.1016/j.ejpsy.2023.100247

3 papers linked to studies included in the review:

Auer R, Schoeni A, Humair J-P, Jacot-Sadowski I, Berlin I, Stuber MJ, Haller ML, Tango RC, Frei A, Strassmann A, Bruggmann P, Baty F, Brutsche M, Tal K, Baggio S, Jakob J, Sambiagio N, Hopf NB, Feller M, Rodondi N, Berthet A, Electronic Nicotine-Delivery Systems for Smoking Cessation, The New England journal of medicine / 2024;390(7):601-610. 10.1056/NEJMoa2308815

Piper ME, Schlam TR, Donny EC, Kobinsky K, Matthews J, Piasecki TM, Jorenby DE, The Impact of Three Alternate Nicotine-Delivery Products on Combusted Cigarette Use: A Randomized Controlled Trial, Nicotine & Tobacco Research, 2024;, ntae014, 10.1093/ntr/ntae014

Correction to Yingst: Changes in Nicotine Dependence Among Smokers Using Electronic Cigarettes to Reduce Cigarette Smoking in a Randomized Controlled Trial, Nicotine & Tobacco Research, 2023;, ntad229, 10.1093/ntr/ntad229

For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Reto Auer, Bern University, Switzerland. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes.

Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation’. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone.

DOI: 10.1056/NEJMoa2308815

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st February found the following

1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).)

3 new ongoing studies:

NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa.

ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness.

Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9

3 papers linked to studies included in the review:

Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people

accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113

Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024

Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023

For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes.

Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation’. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone.

DOI: 10.1056/NEJMoa2308815

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st February found the following

1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).)

3 new ongoing studies:

NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa.

ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness.

Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9

3 papers linked to studies included in the review:

Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113

Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024

Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023

For further details see our webpage under 'Monthly search findings':

https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full

This podcast is supported by Cancer Research UK.

This podcast is supported by Cancer Research UK.