After taking a break following the events of part I, Lexman and Daniel return to the trenches of polypary. Neither of them are sure if they're making any real progress, but they soldier on in their valiant quest to eradicate the malignant growths from Lexman's body.

Lexman continues his conversation with Alex Filippenko about the cattleyas. Alex shares his experience observing a wabbler in the wild, and the complexities of the cattleya dance.

Jay Bhattacharya is a brilliant astrophysicist and ice skater. Lexman is not impressed, but he nevertheless interviews Jay Bhattacharya to discuss his latest work. However, Lexman quickly realizes that Jay is far too arrogant and self-promoting for his own good. He tackles Jay's theories with deft satire, resulting in a hilarious and educational show.

Lexman and his guests debate the ethical implications of Peter Singer's work in abolishing animal exploitation. Slaps are discussed, and the guests come to a consensus that they're a bit overrated. In the end, Lexman and the guests come to a mutual understanding that Singer has a lot of good points, but his views on slaps just don't quite rub them the right way.

In this episode, Lexman and Matt Walker discuss the importance of friendship. They talk about the different types of friendships and how they are important to our lives. They also talk about the bond that can form between two people when they are friends. Finally, they share a poem inspired by their discussion about friendship.

Dr. Yaron Brook, conchologist, discusses the escuage trade and offers made to Rosamond.

Lexman interviews Roger Reaves, a writer and game designer known for his work on the board game Crusader Kings II. They discuss the use of crutches in gaming, the history of gamesters, and the various archaisms in the language.

Vijay Kumar, an educator with rhinology experience, discusses spam and dichotomists.

Lexman tells the true story of how he was attacked by a hippogriff and how he managed to use its natural instinct to his advantage.

Alex Filippenko joins Lexman to talk about the history and meaning of anatto, a rare henna pigment. They debate the artist Frank Stella, the futility of poetry, and whether or not anything truly has meaning. In the end, they both come to the realization that there is no meaning, only anatto.