Currently, mRNA-based vaccines are being developed for treating various diseases including cancers. For this purpose, synthetic or in vitro transcribed (IVT) mRNA encoding tumor antigen offers several advantages over plasmid DNA encoding tumor antigen including better delivery and security. Liposomes/Polymer/mRNA ternary complexes termed lipoplyplexes (LPR) can be used to deliver mRNA encoding antigen in vivo. Studies reported the preparation of mannosylated mRNA nanoparticles (Man-LPR) loaded with mRNA encoding a melanoma antigen MART-1. Immunization with LPR instigated extremely potent T-cell responses and showed superior effectiveness in controlling tumor growth compared to intravenous immunization with antigen mRNA electroporated DCs.

https://mrna.creative-biolabs.com/technologies-platforms.htm

Researches show that this approach results in long-lasting clinical remission in cancer patients and protective immunity against infections. Here we make a brief introduction about two technologies widely used in mRNA research.https://mrna.creative-biolabs.com/technologies-platforms.htm

Increasing evidence revealed that mRNA molecules play a significant role in the progression of some diseases, which provides a new sight to use mRNA as a drug for the treatment of genetic diseases.https://mrna.creative-biolabs.com/technology.htm

The recognition of the importance of mRNA turnover in regulating eukaryotic gene expression has facilitated the development of reliable and rigorous systems to measure changes in mRNA stability accurately in mammalian cells. Considering these concerns, Creative Biolabs provides the tetracycline-regulated (Tet-off) promoter system, which exploits a tetracycline-repressible promoter to explain better mechanisms of mRNA turnover in both tissue culture mammalian cells and animals.https://mrna.creative-biolabs.com/tet-off-regulatory-promoter-system.htm

A more recently developed Tet-off regulatory promoter system offers an alternate strategy that further broadens the application of the pulsing transcriptional approach to study mRNA turnover in mammalian cells. https://mrna.creative-biolabs.com/tet-off-regulatory-promoter-system.htm

https://mrna.creative-biolabs.com/therapeutic-antibody-coding-mrna.htm

An elegant solution to circumvent the problems of complex production, purification processes and aberrant post-translational modifications of the monoclonal antibody (mAb), is to deliver the genetic information of the antibody itself.https://mrna.creative-biolabs.com/therapeutic-antibody-coding-mrna.htm

mRNA-mediated antibody expression is applicable to oncology as well as infectious diseases and may provide advantages compared to recombinant biologics in certain instances such as short-lived antibody formats.

https://mrna.creative-biolabs.com/therapeutic-antibody-coding-mrna.htm

Nowadays, different approaches to turning messenger RNA (mRNA) into a potent therapeutic have been developed. All of them share utilization of specifically designed, instead of endogenous sequences and thorough purification protocols.https://mrna.creative-biolabs.com/therapeutic-antibody-coding-mrna.htm

A full range of services targeting mRNA-based regenerative medicine according to customer's detailed requirements. https://mrna.creative-biolabs.com/mrna-for-regenerative-medicine.htm