At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.

                              __________________________________________

In this episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of calorie restriction and fasting, two of the most studied interventions for healthy aging.

Drawing on decades of research, Dr. Sinclair explains how eating less – and eating less often – affects the biology of aging, why our evolutionary past may predispose many of us to weight gain, and what the latest human and animal studies reveal about lifespan, metabolism, and disease risk.

Whether you're interested in longevity, metabolism, or intermittent fasting, this episode provides an evidence-based look at one of the most powerful strategies for supporting health and longevity.

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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN

                               __________________________________________

Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. 

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.  

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.

                              __________________________________________

In this first episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and pioneer in longevity research - returns and explores one of the most consequential questions in science: How can aging be slowed or reversed?

Drawing on more than 25 years of research at the forefront of aging biology, Dr. Sinclair explains why humanity has entered a revolutionary period. Advances in science and technology have converged and transformed aging into a promising target for intervention.

This episode is a sweeping introduction to the science, breakthroughs, and emerging technologies that are fundamentally reshaping how we think about aging, disease, and the future of human health.

                               __________________________________________

Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN

                               __________________________________________

Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. 

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.  

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

What are the most important things you can do today to live longer and stay healthier while doing it?

What if aging is more reversible than we once thought?

What are the most important things you can do today to live longer and stay healthier while doing it?

In this first Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most impactful insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application.

This episode covers:

What to eat – and what to avoid – for long-term health

How to think about exercise for longevity (not just performance)

The role of cold and heat exposure

Which supplements may support healthy aging

Emerging medical interventions and what the science actually shows

The tools and protocols Dr. Sinclair personally uses in his own routine

Whether you're new to longevity science or looking to refine your approach, this episode brings together the most important principles in one place so you can better understand not just what to do, but why it matters.

At Lifespan, our mission is to help you and your loved ones live longer, healthier lives while supporting medical research aimed at breakthroughs to extend all our lives.

Join us at: https://lifespan.com. We’re building the world’s largest longevity community who will grow, learn, and live longer together. 

Subscribe here for new Lifespan show episodes every two weeks.

                               __________________________________________

Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in strong science – and products our team has personally used for many years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode – from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat content and muscle gains (Withings).

If you’d like to learn more or try these tools:

Ketone-IQ: Get 30% off your first monthly order at ketone.com/lifespan with code LIFESPAN

WHOOP: Get a free WHOOP band plus one month free at join.whoop.com/LIFESPAN with code LIFESPAN

Withings: Explore their smart health devices at withings.com/lifespan using code LIFESPAN

                               __________________________________________

Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship. 

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.  

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered.

Thank you to our sponsors:

Our Patreon page: https://www.patreon.com/davidsinclair 

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

Matthew LaPlante's Social:

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Introducing Episode Eight: The Future of Anti-aging Medicine

(00:03:49) Thanking the Sponsors

(00:06:48) Modern Healthcare, Disease Detection, and Circulating DNA

(00:11:30) Wearable Monitors: A Dashboard for your Body

(00:20:31) Types of Health Sensors

(00:24:20) Big Data, Privacy, and Criminal Investigation

(00:30:16) Cutting-edge Testing and Biological Age

(00:36:40) Using Personalized Data to Inform your Diet

(00:41:48) Optimizing Exercise and Activity-mimetics

(00:45:02) Resetting the Aging Clock

(00:53:45) Repeatable Age Reversal and Safety

(00:56:11) Longer Life, Population Size, and Economics

(01:00:18) Skillbatical

(01:03:06) Putting in the Work for Longevity

(01:04:56) Thanking the Podcast Team and Wrapping Up Season One

(01:08:27) Options for Subscription and Support

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

Thank you to our sponsors:

Our Patreon page: https://www.patreon.com/davidsinclair 

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

Matthew LaPlante's Social:

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Introducing Episode Seven: Aging of the Brain

(00:04:39) Thanking the Sponsors

(00:07:38) Ex-differentiation as a Driver of Aging

(00:09:22) The Brain Ages Slowly

(00:14:17) Cognitive Function and Plasticity

(00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins

(00:23:26) Plant-based Diets and B-vitamins

(00:28:32) Homocysteine, Plaque, and Vasculature

(00:32:35) Fatty Acids

(00:35:48) Physical Activity

(00:39:14) Metformin

(00:46:02) NAD Boosters

(00:50:33) Increasing Blood Flor

(00:53:20) Sleep

(00:58:02) Overall Message: Keep your Brain Healthy

(00:58:50) Next Week’s Episode and the Future of Medicine

(01:01:21) Options for Subscription for Support

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.

Thank you to our sponsors:

Our Patreon page: https://www.patreon.com/davidsinclair 

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

Matthew LaPlante's Social:

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Timestamps:

(00:00:00) Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair

(00:02:54) Estrogen, Progesterone, and Menopause

(00:09:51) Thanking the Sponsors

(00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers

(00:18:29) Skin and Biological Aging

(00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging

(00:28:15) Collagen, Keratin, and Skin Health

(00:33:38) A Quick Aside about Nails

(00:34:45) Autophagy and Retinoids

(00:36:57) Resveratrol, NAD Boosters, and Hyaluronic Acid

(00:41:44) Botox, Skin Peels, and Microneedling

(00:43:28) No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food

(00:45:42) Hair Loss and Hair Graying

(00:49:45) Topical Treatments, Pills, and Dihydrotestosterone

(00:55:19) Frickin Laser Beams: Low-level Laser Therapy

(00:57:59) Platelet-rich Plasma (PRP) Injections

(01:00:11) Hair Aging, Stress, and Gray Hair Reversal

(01:06:11) Targeting Aging Upstream

(01:07:37) Today’s Takeaways

(01:09:25) Subscription and Support Options

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.

Thank you to our sponsors:

Our Patreon page: https://www.patreon.com/davidsinclair 

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Matthew LaPlante's Social:

Timestamps:

(00:00:00) Kicking Off Episode Five: Interventions on the Cutting Edge

(00:02:39) Expressing Gratitude to the Sponsors

(00:05:28) Testosterone Replacement Therapy

(00:10:09) Human Growth Hormone

(00:13:56) Peptide Supplementation and Regenerative Signaling

(00:18:11) MOTS-c, Humanin, and Other Peptides

(00:25:05) Exosome Therapy

(00:31:56) A Primer on Stem Cells and Yamanaka Factors

(00:37:59) Stem Cell Aging and Cord Blood Banking

(00:41:42) The Therapeutic Potential of Stem Cells

(00:43:37) Cellular Reprogramming

(00:51:35) Resetting the Aging Clock

(00:56:50) The Future Looks Bright

(00:58:15) Next Week’s Episode: External Aging

(00:58:36) Subscription and Support Options

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.

Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion.

Thank you to our sponsors:

Our Patreon page: https://www.patreon.com/davidsinclair 

Lifespan book: https://amzn.to/3sUqurT

Dr. David Sinclair Social:

To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.

Matthew LaPlante's Social:

Timestamps:

(00:00:00) Kicking Off Episode Four: Longevity Molecules

(00:02:15) Thanks the Sponsors

(00:04:46) An An Additional Boost Beyond Adversity Mimetics

(00:05:52) Drugs vs. Supplements and Highlight Points

(00:09:54) Longevity Molecules Target the Survival Circuit

(00:11:33) NAD Boosters

(00:13:32) Nicotinamide Riboside

(00:21:26) Nicotinamide Mononucleotide

(00:29:22) NAD Intravenous Drips

(00:32:45) Bioavailability of NAD Boosters

(00:33:40) NAD and Cancer

(00:35:33) Resveratrol

(00:42:26) Red Wine and the French Paradox

(0043:08) Fisetin and Quercetin

(00:47:09) Rapamycin and Rapalogs

(00:49:10) Spermidine

(00:51:27) Metformin

(01:00:27) Berberine

(01:02:43) Dr. Sinclair’s Protocol for Longevity Molecules

(01:08:51) Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge

(01:09:52) Options for Subscription and Support

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.