Controlling the HIV epidemic depends on shifting from fragmented, donor-led programmes to nationally led, integrated health systems. To accompany a new joint Series of six papers, Peter Hayward, Editor-in-chief of The Lancet HIV, and Gavin Cleaver, Senior Editor at The Lancet Global Health, are joined in conversation by Solange Baptiste, Kenneth Ngure, and Charles Holmes, who worked extensively on the Series.

Why do some people living with HIV struggle with sleep? Luxena Sukuraman and Alan Winston help us understand the challenges of disordered sleep in HIV, what clinicians can do to help, and practical sleep hygiene tips for people living with HIV experiencing sleep disturbances.

In the ongoing search for an HIV cure, promising evidence suggests that early treatment of infants might help achieve lasting HIV remission: the IMPAACT P1115 study is designed to investigate that potential. We talk to a lead investigator about what we know so far.

Jayne Ellis from the London School of Hygiene and Tropical Medicine discusses new research showing why targeting cytomegalovirus could be key to improving outcomes for people living with advanced HIV.

Maggie Walters and Michelle Bulterys talk us through their research into factors that affect the probability of vertical transmission and what it says about efforts to end new infant acquisitions.

Mansoor Farahani, Wafaa El-Sadr, and Wilford L. Kirungi discuss the strategies behind Uganda’s success, the challenges that still lie ahead, and how a current global funding crisis could impact the fight against HIV in the country.

In HIV prevention and treatment, broadly neutralising antibodies have so far failed failed to deliver on their potential; could N6LS buck the trend? Richard Wu talks about a phase 1 study with some promising results.

Join Adrian Gonzalez in conversation with Grace Lui and Vincent Wong (The Chinese University of Hong Kong) as they discuss whether a dietary and exercise programme can reduce liver fat and induce resolution of MASLD in people with HIV.

Peter Hayward talks to Dr Bridget Mugisa (WHO, Eastern Mediterranean Office, Egypt) about a study summarising the epidemiology of HIV in the Middle East and north Africa.

Dr Amy Justice (Yale University, USA) talks to Philippa Harris about the joint The Lancet HIV and The Lancet Healthy Longevity Series Ageing with HIV.