Julia Marcus and Douglas Krakower talk to Peter Hayward about the use of electronic health record data to predict HIV risk and identify PrEP candidates.

The Lancet HIV Editor Peter Hayward talks to Beatriz Grinsztejn (Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil) about ACTG A5288, an international, multiarm trial investigating management of second-line treatment failure

The Lancet HIV Deputy Editor Philippa Harris talks to Betsy Herold (Albert Einstein College of Medicine, USA) about her trial investigating a tenofovir disoproxil fumarate intravaginal ring for pre-exposure prophylaxis in sexually active women.

Sheree Schwartz (Johns Hopkins School of Public Health) talks to The Lancet HIV Editor-in-Chief Peter Hayward about the Sakh'umndeni Safer Conception Project safer conception project for South African couples living with HIV.

Sunil Solomon (Johns Hopkins School of Medicine, USA) discusses the trials and tribulations of investigating integrated HIV testing, prevention, and treatment centres for people who inject drugs and men who have sex with men in India.

The Lancet HIV Editor Peter Hayward talks to Evgeny Krupitsky about a trial investigating the potential of slow-release naltrexone to improve HIV treatment adherence in drug users in St Petersburg.

The Lancet HIV Deputy Editor Liz Zuccala joins Stephanie Cohen to discuss a case report of an individual who acquired HIV despite reporting good adherence to PrEP.

For World AIDS Day we explore how, despite huge advances, children are affected by HIV in 2018. We speak to Martina Penazzato of WHO on drug options and development, to Mark Cotton (Stellenbosch University) on the course of HIV management from infancy to adolescents (12 min 03), and to Tamsen Rochat (Human Sciences Research Council in South Africa) on how HIV still impacts the lives of children who don’t have the virus (26 min 33).

Andrew Grulich joins The Lancet HIV editor-in-chief Peter Hayward to discuss the EPIC-NSW study, looking at the population-level effectiveness of PrEP in New South Wales, Australia.

Peter Hayward and Gregg Gonsalves discuss a new modelling study looking at an outbreak of HIV in Scott County, Indiana, USA.