The episode examines the perplexing series of disappearances and deaths of college students in La Crosse, Wisconsin, many of whom were found in the Mississippi River. It contrasts two primary explanations: the official stance of alcohol-related accidental drownings and the persistent theory of a serial killer, often linked to the "Smiley Face Killers" hypothesis. The source highlights the recurring patterns in these cases, such as victims being young, primarily male students last seen leaving bars, and the recent death of Eliotte Heinz, which has reignited public debate. It also discusses the profound impact on the community, including grief, fear, and efforts like "Operation: River Watch," while exploring the psychological and cultural factors that sustain the serial killer narrative despite official denials.