The daughter of a prominent Roman family, she was given in marriage despite her reluctance, but was widowed after less than a year. Following the example of the prophetess Anna, she dedicated her widowhood to God and turned her fine house in Rome into a monastery, living there in strict asceticism.

“When the Church was riven by controversies about the doctrines of Origen, Saint Marcella kept silent for a while but, deciding at length to take up the cause of Orthodoxy, and maintaining a sweet and gentle manner in the exchanges, she succeeded in confounding the arguments of the heretics.” (Ormylia Synaxarion)

When the Goths invaded and pillaged Rome in 410 they broke into her house. Marcella received them calmly, but when they demanded money she answered that no one as poorly clothed as she was could be expected to have any money. At this the invaders beat her mercilessly despite her great age. She bore their blows without complaint, asking only that they spare her spiritual daughter Principia. Struck to the heart by her response, the barbarians took her and her disciple to the Church of St Paul, where she reposed two days later.